Microsatellite analysis in two populations of Kunming mice

Shang, Haitao; Wei, Hong; Bing-fei, Yue; Xu, Ping; Huang, Honggang

doi:10.1258/la.2008.008098

Cited by 46 publications

(14 citation statements)

References 19 publications

(17 reference statements)

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“…These mice show: high disease resistance, good adaptive capacity, high breeding coefficient, and good survival rate. 34 In this study we analyzed: 1) if gestational stress induces depressive-like and anxiety-like behavior in offspring and 2) if such behavior changes are associated with epigenetic alterations of BDNF. The goal of the present study was to increase the understanding of epigenetic mechanisms underlying development of depression by recapitulating interactions between genes and the environment in animal models.…”

Section: -33mentioning

confidence: 99%

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

et al. 2016

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Exposure to stressful life events during pregnancy exerts profound effects on neurodevelopment and increases the risk for several neurodevelopmental disorders including major depression. The mechanisms underlying the consequences of gestational stress are complex and remain to be elucidated. This study investigated the effects of gestational stress on depressive-like behavior and epigenetic modifications in young adult offspring. Gestational stress was induced by a combination of restraint and 24-hour light disturbance to pregnant dams throughout gestation. Depressive-like and anxiety-like behaviors of young adult offspring were examined. The expression and promoter methylation of brain derived neurotrophic factor (BDNF) were measured using RT-qPCR, Western blot, methylated DNA immunoprecipitation (MeDIP) and chromatin immunoprecipitation (ChIP). In addition, the expressions of histone deacetylases (HDACs) and acetylated histone H3 lysine 14 (AcH3K14) were also analyzed. Our results show that offspring from gestational stress dams exhibited depressive-like and anxiety-like behaviors. Biochemically, stress-offspring showed decreased expression of BDNF, increased expression of DNMT1, HDAC1, and HDAC2, and decreased expression of AcH3K14 in the hippocampus as compared to non-stress offspring. Data from MeDIP and ChIP assays revealed an increased methylation as well as decreased binding of AcH3K14 on specific BDNF promoters. Pearson analyses indicated that epigenetic changes induced by gestational stress were correlated with depressive-like and anxiety-like behaviors. These data suggest that gestational stress may be a suitable model for understanding the behavioral and molecular epigenetic changes observed in patients with depression.

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Section: -33mentioning

confidence: 99%

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

et al. 2016

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“…Kunming mice originated from Swiss mice brought from the Indian Haffkine Institute to Kunming, China, in 1944(Shang et al, 2009). Due to high disease resistance and good adaptive capacity, Kunming mice were widely utilized in the pharmacological and biological research, such as lipid metabolism study (He et al, 2009;Ma et al, 2009).…”

Section: Animals and Restraint Treatmentmentioning

confidence: 99%

Phloridzin improves lipoprotein lipase activity in stress-loaded miceviaAMPK phosphorylation

Wang

et al. 2014

International Journal of Food Sciences and Nutrition

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Long-term stress exposure can lead to disturbed homeostasis and cause many life-style diseases. Phloridzin possesses various bioactivities, but the understanding of the effects of phloridzin on stress-related lipid metabolism disorder is limited. Our results demonstrate that phloridzin improved plasma lipoprotein lipase (LPL) activity and triglyceride metabolism in restrained mice. A decrease of angiopoietin-like protein 4 (ANGPTL4) mRNA expression and an increase of AMP-activated protein kinase (AMPK) phosphorylation were observed after phloridzin treatment. After inhibiting AMPK phosphorylation, the effects of phloridzin on the amelioration of plasma LPL activity and suppression of ANGPTL4 expression were blocked. In addition, cardiac AMPK phosphorylation, plasma LPL activity and ANGPTL4 expression were also affected by phloridzin, even if the glucocorticoid receptor was blocked. Taken together, the down-regulation of ANGPTL4 expression by phloridzin was probably via a direct activation of AMPK pathway. This discovery can provide a biochemical and nutritional basis for the use of phloridzin-containing food and beverage in daily life.

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“…The Kunming mouse strain originated from Swiss mice brought to Kunming, China, from the Indian Haffkine Institute in 1944 [29] . Similar numbers of male and female mice were used in the current study.…”

Section: Micementioning

confidence: 99%

Signaling via Dopamine D1 and D3 Receptors Oppositely Regulates Cocaine-Induced Structural Remodeling of Dendrites and Spines

Zhang

Li²,

Liu³

et al. 2011

Neurosignals

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Repeated exposure to cocaine can induce persistent alterations in the brain. The structural remodeling of dendrites and dendritic spines is thought to play a critical role in cocaine addiction. We previously demonstrated that signaling via dopamine D1 and D3 receptors have opposite effects on cocaine-induced gene expression. Here, we show that cocaine-induced structural remodeling in the nucleus accumbens (NAc) and caudoputamen (CPu) is mediated by D1 receptors and inhibited by D3 receptors. In addition, chronic exposure to cocaine results in an altered number of asymmetric spine synapses via the actions of both D1 and D3 receptors. The contradictory effects of D1 and D3 receptor signaling on cocaine-induced structural remodeling is associated with NMDA-receptor R1 subunit (NR1) phosphorylation, and is dependent upon the activation of extracellular signal-regulated kinase (ERK). In addition, we found that D1 and D3 receptor signaling has contradictory effects upon the activation of the myocyte enhancer factor 2 (MEF2), which is involved in the dendritic remodeling after cocaine treatment. Together, these data suggest that dopamine D1 and D3 receptors differentially regulate the cocaine-induced structural remodeling of dendrites and spines via mechanisms involving the consecutive actions of NR1 phosphorylation, ERK activation, and MEF2 activity in the NAc and CPu.

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Microsatellite analysis in two populations of Kunming mice

Cited by 46 publications

References 19 publications

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

Phloridzin improves lipoprotein lipase activity in stress-loaded miceviaAMPK phosphorylation

Signaling via Dopamine D1 and D3 Receptors Oppositely Regulates Cocaine-Induced Structural Remodeling of Dendrites and Spines

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