MicroRNAs Responsible for Inflammation in Obesity

Brettfeld, Caroline; Maver, Aleš; Aumüller, Eva; Peterlin, Borut; Haslberger, Alexander

doi:10.14740/jem399w

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…Further examination of hsa-miR-328 identified associations with cancer (48,49). MiR-328 has been known to play a role in myocardial infarction and cancers in adults, where obesity is an established risk factor (50). A study examining childhood obesity and circulating miRNAs found that circulating concentrations of hsa-miR-328 were higher in obese compared to lean children (51).…”

Section: Discussionmentioning

confidence: 99%

Body mass index in relation to extracellular vesicle–linked microRNAs in human follicular fluid

Martinez

Baccarelli

Liang

et al. 2019

Fertility and Sterility

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Objective: To study whether increased body mass index is associated with altered expression of extracellular vesicle microRNAs (EVlinked miRNAs) in human follicular fluid. Design: Cross-sectional study. Setting: Tertiary-care university-affiliated center. Patient(s): One hundred thirty-three women undergoing in vitro fertilization (IVF) were recruited from January 2014 to August 2016. Interventions(s): None. Main Outcome Measure(s): EV-linked miRNAs were isolated from follicular fluid and their expression profiles were measured with the use of the Taqman Open Array Human miRNA panel. EV-linked miRNAs were globally normalized and inverse-normal transformed. Associations between body mass index (BMI) and EV-linked miRNA outcomes were analyzed by means of multivariate linear regression and principal component analysis. Result(s): Eighteen EV-linked miRNAs were associated with an increase in BMI after adjusting for age, ethnicity, smoking status, and batch effects. Hsa-miR-328 remained significant after false discovery rate adjustments. Principal component analyses identified the first principal component to account for 40% of the variation in our EV-linked miRNA dataset, and adjusted linear regression found that the first principal component was significantly associated with BMI after multiple testing adjustments. Using Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we predicted gene targets of EV-linked miRNA in silico and identified PI3K-Akt signaling, ECM-receptor interaction, focal adhesion, FoxO signaling, and oocyte meiosis pathways. Conclusion(s):These results show that a 1-unit increase in BMI is associated with altered follicular fluid expression of EV-linked miRNAs that may influence follicular and oocyte developmental pathways. Our findings provide potential insight into a mechanistic explanation for the reduced fertility rates associated with increased BMI. (Fertil Steril Ò 2019;112:387-96. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Section: Discussionmentioning

confidence: 99%

Body mass index in relation to extracellular vesicle–linked microRNAs in human follicular fluid

Martinez

Baccarelli

Liang

et al. 2019

Fertility and Sterility

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“…Interestingly, miR-221 is elevated during obesity [313] and associated to EC dysfunction in the progression of atherosclerosis [314]. Both miR-145 and miR-494 are related to obesity [315,316] and atherosclerosis [317][318][319].…”

Section: Endoplasmic Reticulum (Er) Stress and Mirnasmentioning

confidence: 99%

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

Ait‐Aissa¹,

Nguyen²,

Gabani³

et al. 2020

Cardiovasc Diabetol

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The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardiovascular diseases. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that play important roles in a variety of cellular processes such as differentiation, proliferation, apoptosis, and stress response; their alteration contributes to the development of many pathologies including obesity. Mediators of obesity-induced endothelial dysfunction include altered endothelial nitric oxide synthase (eNOS), Sirtuin 1 (SIRT1), oxidative stress, autophagy machinery and endoplasmic reticulum (ER) stress. All of these factors have been shown to be either directly or indirectly caused by gene regulatory mechanisms of miRNAs. In this review, we aim to provide a comprehensive description of the therapeutic potential of miRNAs to treat obesity-induced endothelial dysfunction. This may lead to the identification of new targets for interventions that may prevent or delay the development of obesity-related cardiovascular disease.

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“…found that miR-378 was directly involved in adipose tissue inflammation as well as obesity-related disease. 14 Finally, it was established that miR-378 is abundantly expressed in synovial fluid in late-stage OA. 15 However, the exact function and mechanism of miR-378 during OA development remains speculative.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

Feng¹,

Yang²,

Li³

et al. 2022

Molecular Therapy - Nucleic Acids

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MicroRNAs Responsible for Inflammation in Obesity

Cited by 6 publications

References 55 publications

Body mass index in relation to extracellular vesicle–linked microRNAs in human follicular fluid

Body mass index in relation to extracellular vesicle–linked microRNAs in human follicular fluid

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis

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