MicroRNAs: pivotal regulators in acute myeloid leukemia

Li, Mingyu; Cui, Xianglun; Guan, Hongzai

doi:10.1007/s00277-019-03887-5

Cited by 17 publications

(10 citation statements)

References 135 publications

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“…miRNAs are small ncRNAs approximately 19–22 nt in length ( 28 , 29 ) that trigger translational repression of target mRNAs by recruiting an RNA-induced silencing complex and binding to miRNA response elements ( 30 , 31 ). Previous studies have reported that lncRNAs relieve translational repression mediated by miRNAs by sequestering miRNAs or competitively binding to their targets ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression

Jiang

Luo

2022

Oncol Lett

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Breast cancer (BC) is a malignant disease and the most commonly diagnosed cancer in women. Numerous studies have previously verified the important role of long non-coding RNAs in a number of biological processes in BC. In the present study, analysis of The Cancer Genome Atlas database and reverse transcription-quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC. Gain or loss of function assays indicated that overexpression of LOC102724163 significantly increased tumorgenicity in vivo and cell migration, proliferation and invasion in vitro . In the mechanistical aspect, LOC102724163 sponged microRNA (miR)-508-5p to elevate MUC19 expression. Additionally, rescue assays ascertained the function of the LOC102724163 /miR-508-5p/ MUC19 axis in the proliferation and invasion of BC cells. To the best of our knowledge, this is the first study to have demonstrated that LOC10272416 3 may act as a competing endogenous RNA to control MUC19 expression levels by competitively sponging miR-508-5p to modulate BC progression. Therefore, the present study has provided new insights into BC diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression

Jiang

Luo

2022

Oncol Lett

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“…Over the last decade, significant efforts have been made to elucidate the molecular changes in genome-wide profiling involved in AML oncogenesis. Such studies have contributed to the determination of relevant biomarkers and even therapeutic targets, including protein coding genes, microRNAs and long non-coding RNAs [ 25 – 27 ]. In addition, as a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, AS events have been shown to have the potential in predicting clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Clusterization in acute myeloid leukemia based on prognostic alternative splicing signature to reveal the clinical characteristics in the bone marrow microenvironment

Zhang

Chen

et al. 2020

Cell Biosci

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Background Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, still faces various challenges in the splicing regulation mechanism of acute myeloid leukemia (AML) and microenvironmental changes. Results A total of 27,833 AS events were detected in 8337 genes in 178 AML patients, with exon skip being the predominant type. Approximately 11% of the AS events were significantly related to prognosis, and the prediction models based on various events demonstrated high classification efficiencies. Splicing factors correlation networks further altered the diversity of AS events through epigenetic regulation and clarified the potential mechanism of the splicing pathway. Unsupervised cluster analysis revealed significant correlations between AS and immune features, molecular mutations, immune checkpoints and clinical outcome. The results suggested that AS clusters could be used to identify patient subgroups with different survival outcomes in AML, among which C1 was both associated with good outcome in overall survival. Interestingly, C1 was associated with lower immune scores compared with C2 and C3, and favorable-risk cytogenetics was rarely distributed in C2, but much more common in C1. Conclusions This study revealed a comprehensive landscape of AS events, and provides new insight into molecular targeted therapy and immunotherapy strategy for AML.

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“…Besides, a tremendous amount of document reported that miRNAs were also involved in the malignant transformation and tumor progression by exerting pivotal effects on oncogenes and suppressor genes through a series of signaling axis including NF-κB, MAPK, PI3K/AKT/mTOR and Wnt/β-catenin [ 32 , 33 ].…”

Section: Biogenesis Of Mirnasmentioning

confidence: 99%

MicroRNAs: emerging driver of cancer perineural invasion

et al. 2021

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The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pathogenesis of PNI switches from ‘low-resistance channel’ hypothesis to ‘mutual attraction’ theory between peripheral nerves and tumor cells in perineural niche. Among various molecules in perineural niche, microRNA (miRNA) as an emerging modulator of PNI through generating RNA-induced silencing complex (RISC) to orchestrate oncogene and anti-oncogene has aroused a wide attention. This article systematically reviewed the role of microRNA in PNI, promising to identify new biomarkers and offer cancer therapeutic targets.

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MicroRNAs: pivotal regulators in acute myeloid leukemia

Cited by 17 publications

References 135 publications

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression

Clusterization in acute myeloid leukemia based on prognostic alternative splicing signature to reveal the clinical characteristics in the bone marrow microenvironment

MicroRNAs: emerging driver of cancer perineural invasion

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