MicroRNAs: Novel components in a muscle gene regulatory network

Wang, Huating; Sun, Hao; Guttridge, Denis C.

doi:10.4161/cc.8.12.8851

Cited by 18 publications

(19 citation statements)

References 60 publications

(88 reference statements)

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“…54 During myogenic differentiation, miR-29 is induced and it inhibits the expression of YY1, resulting in a robust upregulation of this myogenic miRNA. 54,107 In rhabdomyosarcoma cells and primary tumors where YY1 is elevated, miR-29 is silenced and differentiation is therefore impaired. 54,107 Similarly, miR-214 expression is suppressed in myoblasts by its target Ezh2.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

“…54,107 In rhabdomyosarcoma cells and primary tumors where YY1 is elevated, miR-29 is silenced and differentiation is therefore impaired. 54,107 Similarly, miR-214 expression is suppressed in myoblasts by its target Ezh2. Upon differentiation Ezh2 is disengaged from the miR-214 promoter, which is then occupied and activated by MyoD and myogenin, leading to miR-214 expression.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

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MicroRNAs in skeletal myogenesis

2011

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Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

MicroRNAs in skeletal myogenesis

2011

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“…A subset of these miRNAs, miR-1, miR-133, and miR-206, play central regulatory roles in muscle biology and are called muscle miRs. In addition to the above muscle miRs, emerging evidence also supports the involvement of non-muscle miRs in myogenesis (5). In an effort to elucidate the transcriptional and post-transcriptional regulation during skeletal myogenesis, we identified an NF-B (NF-B)-Yin Yang1 (YY1)-miR-29 signaling axis (6).…”

mentioning

confidence: 90%

“…As members of Polycomb group proteins (PcGs), YY1 and Ezh2 together regulate a number of muscle loci including both muscle structure genes and muscle relevant miRNAs (5). The PcG genes encode a structurally diverse group of proteins, which form large complexes arising from their mutual interactions.…”

mentioning

confidence: 99%

A Novel Target of MicroRNA-29, Ring1 and YY1-binding Protein (Rybp), Negatively Regulates Skeletal Myogenesis

Zhou

Wang

et al. 2012

Journal of Biological Chemistry

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Background: MicroRNA-29-YY1 regulatory circuitry functions during skeletal myogenesis. Results: A genome-wide search revealed Rybp as a novel target of miR-29, and it silences myogenic loci together with YY1. Conclusion: Rybp functions as a repressor of myogenesis. Significance: This study identifies a novel regulatory circuitry underlying muscle formation and highlights the intimate interplay among transcription factors, epigenetic regulators, and microRNAs.

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“…miR-146a and miR-26a positively regulate myogenesis by modulating the expression of the Notch-1 inhibitor, Numb (Kuang et al 2009), and by targeting the polycomb complex member Enhancer of Zeste homolog 2 (Ezh2) (Caretti et al 2004;Wong and Tellam 2008), respectively. miR-29 was recently demonstrated to function as an enhancer of skeletal myogenesis (Wang et al 2008a(Wang et al , 2009a.…”

Section: Microrna-expression Studiesmentioning

confidence: 99%

Molecular genetic studies of gene identification for sarcopenia

et al. 2011

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Sarcopenia, which is characterized by a progressive decrease of skeletal muscle mass and function with aging, is closely related to several common diseases (such as cardiovascular and airway diseases) and functional impairment/disability. Strong genetic determination has been reported for muscle mass and muscle strength, two most commonly recognized and studied risk phenotypes for sarcopenia, with heritability ranging from 30 to 85% for muscle strength and 45-90% for muscle mass. Sarcopenia has been the subject of increasing genetic research over the past decade. This review is designed to comprehensively summarize the most important and representative molecular genetic studies designed to identify genetic factors associated with sarcopenia. We have methodically reviewed whole-genome linkage studies in humans, quantitative trait loci mapping in animal models, candidate gene association studies, newly reported genome-wide association studies, DNA microarrays and microRNA studies of sarcopenia or related skeletal muscle phenotypes. The major results of each study are tabulated for easy comparison and reference. The findings of representative studies are discussed with respect to their influence on our present understanding of the genetics of sarcopenia. This is a comprehensive review of molecular genetic studies of gene identification for sarcopenia, and an overarching theme for this review is that the currently accumulating results are tentative and occasionally inconsistent and should be interpreted with caution pending further investigation. Consequently, this overview should enhance recognition of the need to validate/replicate the genetic variants underlying sarcopenia in large human cohorts and animal. We believe that further progress in understanding the genetic etiology of sarcopenia will provide valuable insights into important fundamental biological mechanisms underlying muscle physiology that will ultimately lead to improved ability to recognize individuals at risk for developing sarcopenia and our ability to treat this debilitating condition.

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MicroRNAs: Novel components in a muscle gene regulatory network

Cited by 18 publications

References 60 publications

MicroRNAs in skeletal myogenesis

MicroRNAs in skeletal myogenesis

A Novel Target of MicroRNA-29, Ring1 and YY1-binding Protein (Rybp), Negatively Regulates Skeletal Myogenesis

Molecular genetic studies of gene identification for sarcopenia

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