MicroRNAs in skeletal myogenesis

Ge, Yejing; Chen, Jiawen

doi:10.4161/cc.10.3.14710

Cited by 145 publications

(136 citation statements)

References 111 publications

(168 reference statements)

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“…The roles of miRNAs in muscle development have attracted much attention and research interest (Ge and Chen, 2011). miR-133a can promote myoblast proliferation through the repression of serum response factor (SRF) expression (Liu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

Yan

Guo

Zhu

et al. 2012

Journal of Experimental Biology

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Section: Discussionmentioning

confidence: 99%

miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

Yan

Guo

Zhu

et al. 2012

Journal of Experimental Biology

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“…These molecules regulate metabolism and cell function via a range of mechanisms (Alvarez-Garcia and Miska, 2005;Rooij et al, 2006;Brase et al, 2010;Krol et al, 2010), and have recently been involved in muscle biology (Chen et al, 2006;Kim et al, 2006;Callis et al, 2007;Eisenberg et al, 2008;Takaya et al, 2009;Chen et al, 2010a, Ge andHan et al, 2011;Koutsoulidou et al, 2011;Xie et al, 2011;Xu et al, 2012). Multiple miRNAs were found to be specifically expressed or highly abundant in skeletal and/or cardiac muscles, and form a distinct muscle miRNA group (Kim et al, 2006;Ge and Chen, 2011). MiR-133a may attenuate apoptosis of myocardiocytes by targeting CASP9 in ischemic postconditioning protection (He et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

microRNA133a TargetsFoxl2and Promotes Differentiation of C2C12 into Myogenic Progenitor Cells

Luo

Ling

et al. 2015

DNA and Cell Biology

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microRNAs are endogenous noncoding RNA molecules of *22 nucleotides that regulate gene function by modification of target mRNAs. Due to tissue specific of miR-133a and miR-1/206 for skeletal muscles, we investigated the role of miR-133a and miR-1/206 in promoting the differentiation of the C2C12 cells. The results show that directly transfecting mature miR-133a, miR-1/206, or combinations (miR-1 and miR-206, miR-1 and miR-133a, and miR-133a and miR-206) into C2C12 cells, respectively, for 5 days induces formation of myogenic progenitor cells. Overexpression of miR-133a and miR-206 in C2C12 cells greatly improved multinucleated myotube formation. microRNA-133a (miR-133a) is highly expressed during human muscle development. Using bioinformatics, we identified one putative miR-133a binding site within the 3¢-untranslated region of the mouse Foxl2 mRNA. The expression of Foxl2 was shown to be downregulated by subsequent western blot analysis.

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“…Through this miR206-mediated negative feedback mechanism, MyoD facilitates progression toward terminal differentiation (Chen et al 2010;Hirai et al 2010). Other microRNAs, controlling many aspects of skeletal muscle development, have been discovered, and future studies will, it is hoped, reveal their in vivo functions in myogenesis (Ge and Chen 2011).…”

Section: Other Mechanisms Of Gene Regulationmentioning

confidence: 99%

Building Muscle: Molecular Regulation of Myogenesis

Bentzinger¹,

Wang²,

Rudnicki³

2012

Cold Spring Harbor Perspectives in Biology

916

878

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SUMMARYThe genesis of skeletal muscle during embryonic development and postnatal life serves as a paradigm for stem and progenitor cell maintenance, lineage specification, and terminal differentiation. An elaborate interplay of extrinsic and intrinsic regulatory mechanisms controls myogenesis at all stages of development. Many aspects of adult myogenesis resemble or reiterate embryonic morphogenetic episodes, and related signaling mechanisms control the genetic networks that determine cell fate during these processes. An integrative view of all aspects of myogenesis is imperative for a comprehensive understanding of muscle formation. This article provides a holistic overview of the different stages and modes of myogenesis with an emphasis on the underlying signals, molecular switches, and genetic networks.

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MicroRNAs in skeletal myogenesis

Cited by 145 publications

References 111 publications

miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle

microRNA133a TargetsFoxl2and Promotes Differentiation of C2C12 into Myogenic Progenitor Cells

Building Muscle: Molecular Regulation of Myogenesis

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