microRNAs in the Regulation of Melanogenesis

Hushcha, Yekatsiaryna; Blo, Irene; Otòn-Gonzalez, Lucia; Mauro, Giulia Di; Martini, Fernanda; Tognon, Mauro; Mattei, Monica De

doi:10.3390/ijms22116104

Cited by 31 publications

(19 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it has been appreciated how EVs secreted into interstitial spaces mediate the interchange between keratinocytes and melanocytes. Keratinocytes communicate with melanocytes via sEVs carrying miRNAs such as miR-203 and miR-3196 with the capacity to modulate pigmentation in addition to known molecules such as the α-melanocyte stimulating hormone (α-MSH) and the adrenocorticotropic hormone (ACTH) ( Hushcha et al, 2021 ). These keratinocytes-derived vesicles increase tyrosinase activity, pigmentation genes and melanin content in recipient melanocytes to stimulate more melanosome production ( Lo Cicero et al, 2015b ).…”

Section: A Role For Evs In Normal Melanocyte/skin Physiology?mentioning

confidence: 99%

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis

Benito-Martín

Jasiulionis

García‐Silva

2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Secreted extracellular vesicles (EVs) are lipid bilayer particles without functional nucleus naturally released from cells which constitute an intercellular communication system. There is a broad spectrum of vesicles shed by cells based on their physical properties such as size (small EVs and large EVs), biogenesis, cargo and functions, which provide an increasingly heterogenous landscape. In addition, they are involved in multiple physiological and pathological processes. In cancer, EV release is opted by tumor cells as a beneficial process for tumor progression. Cutaneous melanoma is a cancer that originates from the melanocyte lineage and shows a favorable prognosis at early stages. However, when melanoma cells acquire invasive capacity, it constitutes the most aggressive and deadly skin cancer. In this context, extracellular vesicles have been shown their relevance in facilitating melanoma progression through the modulation of the microenvironment and metastatic spreading. In agreement with the melanosome secretory capacity of melanocytes, melanoma cells display an enhanced EV shedding activity that has contributed to the utility of melanoma models for unravelling EV cargo and functions within a cancer scenario. In this review, we provide an in-depth overview of the characteristics of melanoma-derived EVs and their role in melanoma progression highlighting key advances and remaining open questions in the field.

show abstract

Section: A Role For Evs In Normal Melanocyte/skin Physiology?mentioning

confidence: 99%

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis

Benito-Martín

Jasiulionis

García‐Silva

2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Melanogenesis can be regulated by epigenetic factors, such as miRNAs, DNA methylation, and posttranscriptional controllers [140,141]. Lower expression of miR-675 and miR-1299 has been demonstrated in skin with melasma compared with the adjacent area [142,143].…”

Section: Miscellaneousmentioning

confidence: 99%

Update on Melasma—Part I: Pathogenesis

Espósito¹,

Cassiano

Silva³

et al. 2022

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Melasma is a multifactorial dyschromia that results from exposure to external factors (such as solar radiation) and hormonal factors (such as sex hormones and pregnancy), as well as skin inflammation (such as contact dermatitis and esthetic procedures), in genetically predisposed individuals. Beyond hyperfunctional melanocytes, skin with melasma exhibits a series of structural and functional alterations in the epidermis, basement membrane, and upper dermis that interact to elicit and sustain a focal hypermelanogenic phenotype. Evolution in the knowledge of the genetic basis of melasma and the cutaneous response to solar radiation, as well as the roles of endocrine factors, antioxidant system, endothelium proliferation, fibroblast senescence, mast cell degranulation, autophagy deficits of the melanocyte, and the paracrine regulation of melanogenesis, will lead to the development of new treatments and preventive strategies. This review presents current knowledge on these aspects of the pathogenesis of melasma and discusses the effects of specific treatments and future research on these issues.

show abstract

“…As we all know, tyrosinase plays an important role in the process of melanogenesis (Hushcha et al, 2021). Tyrosine can be catalyzed, oxidized and polymerized to be pheomelanin.…”

Section: The Synthesis Of Melaninmentioning

confidence: 99%

Review on oral plant extracts in Skin Whitening

WANG¹,

An²,

Qu³

et al. 2022

Food Sci. Technol

View full text Add to dashboard Cite

Skin whitening has become one of the aesthetic problems among humans around the world, especially on women which is highly attention to skin beauty and whitening. Many of the plant extracts in oral energy drinks have whitening effects and good taste, which can support the health of the skin. We use the National Center for Biotechnology Information (NCBI) as a search engine to find literatures about skin whitening, oral plant extracts. This review mainly introduces the mechanism of skin whitening and the application of oral plant extracts in skin whitening. Skin whitening at melanin synthesis, melanosome transport, metabolism, oxidative stress, UV stimulation, other environmental stimulation inseparable. Many oral plant extracts are natural tyrosine inhibitors. The review concludes the melanin synthesis and transporting, pathway of melanin synthesis, whitening mechanism and the function of whitening on Green tea polyphenols, Rose Petal Extract (Rosa gallica), Pears, Peony, Rosa roxburghii Tratt, Olive (Olea europaea L.), Pomegranates, Phyllanthus emblica L., Mulberry extract, Açaí berry, saussurea involucrate flavonoids extract, etc. These will provide a strong foundation for the application of oral plant extracts in skin whitening. Furthermore, the mixture with function of skin whitening/ skin anti-aging / anti-inflammatory antioxidant oral plant extract can be a good candidate for further development on skin care product.

show abstract

microRNAs in the Regulation of Melanogenesis

Cited by 31 publications

References 99 publications

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis

Update on Melasma—Part I: Pathogenesis

Review on oral plant extracts in Skin Whitening

Contact Info

Product

Resources

About