MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma

Xu, Jie; Li, Ji; Zheng, Taihao; Bai, Lan; Liu, Zuojin

doi:10.17219/acem/36460

Cited by 43 publications

(32 citation statements)

References 35 publications

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“…A number of studies have emerged revealing that miRNAs are aberrantly expressed in HCC (35)(36)(37). Changes in miRNA expression have been continuously reported to serve as the main drivers of HCC carcinogenesis and development by regulating a variety of cancer-associated biological processes (22). Notably, miRNAs have been proposed as diagnostic and prognostic biomarkers, as well as effective therapeutic targets for anticancer treatment (38).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, accumulating evidence supports that miRNAs are aberrantly expressed in a substantial number of human disorders including cancer (15)(16)(17); with changes in miRNA expression being reported in HCC (18), colorectal cancer (19), lung cancer and bladder cancer (20,21). In HCC alone, miRNAs have been implicated either as oncogenes or tumor suppressors during oncogenesis and development (22)(23)(24). For instance, miR-1306-3p has been reported to promote growth and metastasis of HCC cells in vitro and in vivo by directly targeting F-box and leucine rich repeat protein 5 (25), whereas the upregulation of miR-506 has been implied to suppress the aggressive characteristics of HCC by targeting interleukin (IL)-8 both in vitro and in vivo (26).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA‑548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein�1

et al. 2019

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Emerging studies have revealed that microRNAs (miRNAs) are aberrantly expressed in hepatocellular carcinoma (HCC), and the dysregulation of miRNAs exerts crucial roles in the carcinogenesis and development of HCC. Therefore, elucidating the relationship between miRNAs and HCC progression is of great importance to develop novel therapeutic techniques and to improve the prognosis of patients with this malignancy. Recently, miR-548b-3p (miR-548b) has been demonstrated to be a cancer-associated miRNA in tongue squamous cell carcinoma and glioma. However, the expression and function of miR-548b in HCC remain poorly understood. In the present study, it was found that miR-548b is expressed at low levels in HCC tissues and cell lines. Decreased miR-548b expression was found to be positively associated with the clinical features of HCC, including the TNM stage and lymph node metastasis. Functional experiments revealed that upregulation of miR-548b expression decreased proliferation and invasion of HCC cells. Specificity protein 1 (SP1) was verified to be a direct target of miR-548b in HCC cells; as Spearman's correlation analysis identified miR-548b expression to be negatively correlated with that of SP1 expression in HCC tissue specimens. In addition, SP1 inhibition exhibited similar effects as miR-548b overexpression in HCC cells. SP1 reintroduction significantly reversed the suppressive effects of miR-548b upregulation on the proliferation and invasion of HCC cells. In conclusion, the results presented in the present study demonstrated that miR-548b may serve as a tumor suppressive miRNA that inhibits the proliferation and invasion of HCC cells by directly targeting SP1. Consequently, miR-548b can be exploited as a novel therapeutic target for treating patients with HCC in the future, but this needs to be investigated further.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA‑548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein�1

et al. 2019

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“…miRNAs can modulate host gene expression and thereby inhibit or enhance HBV replication. [137][138][139] The miR-99 family promotes HBV replication post-transcriptionally through insulin-like growth factor 1 receptor (IGF-1R)/phosphoinositide 3-kinase (PI3K)/ protein kinase B (Akt)/mTOR/ULK1 signaling-induced autophagy. 140 miR-192-3p is a regulator of HBV infection and may play a potential role in hepatocellular carcinoma.…”

Section: Mirs Regulate Autophagy In Viral Diseasesmentioning

confidence: 99%

“…Hepatitis B virus (HBV) is a significant risk factor for the development and progression of hepatocellular carcinoma. miRNAs can modulate host gene expression and thereby inhibit or enhance HBV replication . The miR‐99 family promotes HBV replication post‐transcriptionally through insulin‐like growth factor 1 receptor (IGF‐1R)/phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt)/mTOR/ULK1 signaling‐induced autophagy .…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

et al. 2019

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Autophagy is a highly conserved catabolic process and fundamental biological process in eukaryotic cells. It recycles intracellular components to provide nutrients during starvation and maintains quality control of organelles and proteins. In addition, autophagy is a well‐organized homeostatic cellular process that is responsible for the removal of damaged organelles and intracellular pathogens. Moreover, it also modulates the innate and adaptive immune systems. Micro ribonucleic acids (microRNAs) are a mature class of post‐transcriptional modulators that are widely expressed in tissues and organs. And, it can suppress gene expression by targeting messenger RNAs for translational repression or, at a lesser extent, degradation. Research indicates that microRNAs regulate autophagy through different pathways, playing an essential role in the treatment of various diseases. It is an important regulator of fundamental cellular processes such as proliferation, autophagy, and cell apoptosis. In this review article, we first review the current knowledge of autophagy and the function of microRNAs. Then, we summarize the mechanism of autophagy and the signaling pathways related to autophagy by citing at least the main proteins involved in the different phases of the process. Second, we introduce other members of RNA and report some examples in various pathologies. Finally, we review the current literature regarding microRNA‐based therapies for cancer, atherosclerosis, cardiac disease, tuberculosis, and viral diseases. MicroRNAs can cause autophagy upregulation or downregulation by targeting genes or affecting autophagy‐related signaling pathways. Therefore, the microRNAs have a huge potential in autophagy regulation, and it is the function as diagnostic and prognostic markers.

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“…MicroRNAs have been proposed by numerous studies as promising diagnostic, prognostic, therapeutic and surveillance tools for human cancers because of their critical roles in various biological processes during tumor development and progression [20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics

Todorović

Mandušić

Tadić

et al. 2020

ARCH BIOL SCI BELGRA

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A growing number of studies suggest a tumor suppressive role and potential prognostic signif-icance of miR-30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significant-ly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, pres-ence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data sug-gest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, war-ranting further investigations.

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MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma

Cited by 43 publications

References 35 publications

MicroRNA‑548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein�1

MicroRNA‑548b inhibits proliferation and invasion of hepatocellular carcinoma cells by directly targeting specificity protein�1

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics

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