2019
DOI: 10.1002/biof.1555
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Abstract: Autophagy is a highly conserved catabolic process and fundamental biological process in eukaryotic cells. It recycles intracellular components to provide nutrients during starvation and maintains quality control of organelles and proteins. In addition, autophagy is a well‐organized homeostatic cellular process that is responsible for the removal of damaged organelles and intracellular pathogens. Moreover, it also modulates the innate and adaptive immune systems. Micro ribonucleic acids (microRNAs) are a mature… Show more

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Cited by 52 publications
(45 citation statements)
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References 144 publications
(260 reference statements)
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“…In AS, VSMCs present abnormal proliferation and migration, and foam cells formed by macrophages will gradually accumulate in endothelial cells, thereby forming atherosclerotic plaques. Besides, autophagy and apoptosis of VSMCs are also involved in the development process of AS and play a regulatory role in AS [ [11] , [12] , [13] , [14] , [15] , [16] ].…”
Section: Introductionmentioning
confidence: 99%
“…In AS, VSMCs present abnormal proliferation and migration, and foam cells formed by macrophages will gradually accumulate in endothelial cells, thereby forming atherosclerotic plaques. Besides, autophagy and apoptosis of VSMCs are also involved in the development process of AS and play a regulatory role in AS [ [11] , [12] , [13] , [14] , [15] , [16] ].…”
Section: Introductionmentioning
confidence: 99%
“…The loss of cartilage cells, osteocyte, and osteoblasts is hypothesized to drive SANFH, although the type of cell death is not completely clear. Autophagy is an auto‐catabolic recycling process of eukaryotic cells that is frequently dysregulated in cancer, inflammatory diseases, autoimmune diseases, aging, etc. Our preliminary results show that SANFH is associated with autophagy, and the autophagy‐related Beclin 1 and microtubule‐associated protein 1 light chain 3 (MAP1LC3) are upregulated in osteoblasts.…”
Section: Introductionmentioning
confidence: 75%
“…Additionally, miR-630 is considered to be a target of ATG12 [96]. Beclin-1, the main component of the class III phosphatidylinositol 3-kinase (PI3K-III) complex, is negatively regulated by miR-376b, miR-30a, and miR-216a, which leads to decreased autophagic activity [91,[97][98][99]. Death-associated protein kinase (DAPK) is a wellknown proapoptotic and suppressor of metastasis.…”
Section: The Role Of Micrornas In Autophagy Pathwaysmentioning
confidence: 99%