MicroRNAs in skin tissue engineering

Miller, Keith L.; Brown, David Alan; Ibrahim, Mohamed M.; Ramchal, Talisha D.; Levinson, Howard

doi:10.1016/j.addr.2015.04.018

Cited by 39 publications

(26 citation statements)

References 302 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, fiber scaffoldsparticularly those with aligned fibers-can regulate the maturation of SCs [256,267]. A number of studies have demonstrated the delivery of ncRNAs from tissue engineering scaffolds, thus introducing a novel method for the regulation of gene expression from the delivery platform [220].…”

Section: Scaffold-mediated Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering

Qian

Wang

et al. 2017

Engineering

View full text Add to dashboard Cite

Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs (ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering. The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.

show abstract

Section: Scaffold-mediated Deliverymentioning

confidence: 99%

“…Generally speaking, miRNAs may be modulated by overexpression or silencing in skin tissue engineering [219]. The marriage of ncRNA with skin tissue engineering offers the promise of creating safer, more effective skin tissue engineering for critically important clinical conditions [220].…”

Section: Skin Tissue Engineeringmentioning

confidence: 99%

Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering

Qian

Wang

et al. 2017

Engineering

View full text Add to dashboard Cite

show abstract

“…This is reflected in their movement from stratum basale to stratum corneum, where the cells are finally matured (13). Epiermis primarily serves as a barrier and is comprised mainly of keratinocytes (14). The barriers can be divided into physical, chemical, biochemical, and immunological barriers.…”

Section: Epidermismentioning

confidence: 99%

Potential applications of human artificial skin and electronic skin (e-skin): a review

Saifullah

Sahidayana

MuhamadFarina

et al. 2018

Bioinspired, Biomimetic and Nanobiomaterials

View full text Add to dashboard Cite

, +60129336621 There is an ever increasing need to develop artificial skin that can fully mimic the human skin that it replaces. Skin substitute has been commercialized and used in cosmetics and wound healing treatment, with mixed results obtained. Apart from artificial skin, electronic skin (e-skin) is also widely researched because it can be customized into wearable devices. E-skin is commonly characterized by its flexibility and ability to accommodate a large range of sensors in ultrathin films. This paper reviews current development and technology applied to artificial skin and e-skin. First, the basic layers of normal human skin are introduced. Then current development of artificial skin in cosmetics and grafting applications are mentioned in the next section. Latest technology in the fabrication of e-skin and some of its characteristics in different applications are also discussed. Animal ban for cosmetics testing and its positive effects on the development of alternatives to animal testing in experiments are also explained in this paper. Lastly, the current challenges in skin research and recommendations for future application of artificial skin as well as electronic skin are presented. Bioinspired, Biomimetic and Nanomaterials REVIEW PAPER Keywords: biomimetics\biomaterials\biosensors\self-healing\tissue engineering. ice | science ICE Publishing: All rights reserved differentiation (4,5). To date, there is no artificial skin that could completely replace the actual human skin. However, with the recent progress showing, we are in the right track of producing a reliable and robust artificial skin for general usage. Electronic skin (e-skin) employs the use of sensors to detect changes in environment such as pressure, strain, temperature, and humidity. Technological advancement in the development of e-skin means it has potential use in wearable individual-centered health monitoring, sensitive tactile information acquiring, minimally invasive surgery, and prosthetics (6). The thinness and flexibility of e-skin are some factors that make e-skin desirable and convenient to use. Nonetheless, the challenge lies in creating a tactile-sensing simulation with high resolution, high sensitivity, and rapid response similar to the human skin characteristics (7). This is important as information need to be delivered the fastest way possible in order to provide precise real-time data of the subject.

show abstract

“…The vast potential of miRNA therapies for tissue repair and RM has been extensively reviewed in the last few years in either general terms [25,141] or with more focused applications in mind such as bone/orthopedics, [104,142] angiogenesis, [143] the cardiovascular system, [144] or skin, [145] but the area of scaffold-based miRNA delivery in RM is still relatively in its infancy. To date, reports on scaffold-mediated miRNA delivery have focused more on specific areas of regenerative medicine including osteogenesis and bone repair as well as the cardiovascular arena (Table 2), but this progress report aims to give a broader overview encompassing a variety of areas of RM.…”

Section: Microrna-scaffold Based Therapies For Tissue Repairmentioning

confidence: 99%

Scaffold‐Based microRNA Therapies in Regenerative Medicine and Cancer

Curtin

Castaño

O’Brien

2017

Adv Healthcare Materials

View full text Add to dashboard Cite

The field of "regenerative medicine" (RM) was conceptually developed to aid the body's natural capacity to self-repair, a capacity which is impaired with age and in cases of disease or injury. [1] RM is a vast and multifaceted area of medicine, often microRNA-based therapies are an advantageous strategy with applications in both regenerative medicine (RM) and cancer treatments. microRNAs (miRNAs) are an evolutionary conserved class of small RNA molecules that modulate up to one third of the human nonprotein coding genome. Thus, synthetic miRNA activators and inhibitors hold immense potential to finely balance gene expression and reestablish tissue health. Ongoing industrysponsored clinical trials inspire a new miRNA therapeutics era, but progress largely relies on the development of safe and efficient delivery systems. The emerging application of biomaterial scaffolds for this purpose offers spatiotemporal control and circumvents biological and mechanical barriers that impede successful miRNA delivery. The nascent research in scaffold-mediated miRNA therapies translates know-how learnt from studies in antitumoral and genetic disorders as well as work on plasmid (p)DNA/siRNA delivery to expand the miRNA therapies arena. In this progress report, the state of the art methods of regulating miRNAs are reviewed. Relevant miRNA delivery vectors and scaffold systems applied to-date for RM and cancer treatment applications are discussed, as well as the challenges involved in their design. Overall, this progress report demonstrates the opportunity that exists for the application of miRNA-activated scaffolds in the future of RM and cancer treatments.Regenerative Medicine

show abstract

MicroRNAs in skin tissue engineering

Cited by 39 publications

References 302 publications

Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering

Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering

Potential applications of human artificial skin and electronic skin (e-skin): a review

Scaffold‐Based microRNA Therapies in Regenerative Medicine and Cancer

Contact Info

Product

Resources

About