, +60129336621 There is an ever increasing need to develop artificial skin that can fully mimic the human skin that it replaces. Skin substitute has been commercialized and used in cosmetics and wound healing treatment, with mixed results obtained. Apart from artificial skin, electronic skin (e-skin) is also widely researched because it can be customized into wearable devices. E-skin is commonly characterized by its flexibility and ability to accommodate a large range of sensors in ultrathin films. This paper reviews current development and technology applied to artificial skin and e-skin. First, the basic layers of normal human skin are introduced. Then current development of artificial skin in cosmetics and grafting applications are mentioned in the next section. Latest technology in the fabrication of e-skin and some of its characteristics in different applications are also discussed. Animal ban for cosmetics testing and its positive effects on the development of alternatives to animal testing in experiments are also explained in this paper. Lastly, the current challenges in skin research and recommendations for future application of artificial skin as well as electronic skin are presented. Bioinspired, Biomimetic and Nanomaterials REVIEW PAPER Keywords: biomimetics\biomaterials\biosensors\self-healing\tissue engineering. ice | science ICE Publishing: All rights reserved differentiation (4,5). To date, there is no artificial skin that could completely replace the actual human skin. However, with the recent progress showing, we are in the right track of producing a reliable and robust artificial skin for general usage. Electronic skin (e-skin) employs the use of sensors to detect changes in environment such as pressure, strain, temperature, and humidity. Technological advancement in the development of e-skin means it has potential use in wearable individual-centered health monitoring, sensitive tactile information acquiring, minimally invasive surgery, and prosthetics (6). The thinness and flexibility of e-skin are some factors that make e-skin desirable and convenient to use. Nonetheless, the challenge lies in creating a tactile-sensing simulation with high resolution, high sensitivity, and rapid response similar to the human skin characteristics (7). This is important as information need to be delivered the fastest way possible in order to provide precise real-time data of the subject.