MicroRNAs in Human Placental Development and  Pregnancy Complications

Fu, Guodong; Brkić, Jelena; Hayder, Heyam; Peng, Chun

doi:10.3390/ijms14035519

Cited by 224 publications

(173 citation statements)

References 156 publications

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“…During pregnancy, miRNAs are implicated in a wide range of processes, including preparation of endometrium for implantation, regulation of genes associated with immune response, placental development and angiogenesis [6,7]. Altered expression of these molecules has long been associated with abnormal placentation and pregnancy-related complications.…”

mentioning

confidence: 99%

miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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MicroRNAs (miRNAs) constitute a highly conserved class of small non-coding RNAs, involved in post-transcriptional regulation processes by modifying the expression of specific mRNAs. During placental development, cell differentiation, adhesion, migration, apoptosis and angiogenesis are regulated by specific miRNAs and aberrant expression has been associated with the pathogenesis of pregnancy-related complications. Recent studies focusing on placental and maternal peripheral blood miRNA profiling showed different expression between normal and complicated pregnancies, providing valuable information about the pathophysiological role of miRNAs and identifying potential biomarkers for monitoring pregnancy complications. This review summarizes the current knowledge in the field and presents the possible use of miRNAs as biomarkers for early detection and monitoring of these complications.

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mentioning

confidence: 99%

miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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“…miRNAs are also expressed in the placenta and have been reported in pregnancy complications including GDM and preeclampsia [21,43]. Fu et al identified a series of miRNAs that were involved in dysregulated placental development and function [44]. In our study, the downstream effects analysis among the differentially expressed mRNAs and miRNAs repeatedly predicted the increased proliferation of cells.…”

Section: Discussionmentioning

confidence: 58%

Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus

Ding

Guo

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: The placenta has been suggested to play a crucial role in the pathology of gestational diabetes mellitus (GDM). Placenta-specific microRNAs (miRNAs) and the corresponding targeting genes involved in the pathology of GDM still remain to be elucidated. We aimed to identify the dysregulated miRNAs and the corresponding mRNA targets through an integrated miRNA and mRNA transcriptomic profiles analysis and investigate the role of differentially expressed miR-138-5p/TBL1X in GDM. Methods: RNA sequencing (RNA-seq) was performed in 16 placentas from GDM and control group. Differentially expressed mRNAs and miRNAs in GDM were validated by quantitative PCR (qPCR). The wound healing assay and transwell migration assay were used to analyze cell migration ability. The cell proliferation was determined by CCK8 assay. Luciferase assay was used to confirm the direct binding of the targeted TBL1X with miR-138-5p. Results: Totally, 281 mRNAs and 32 miRNAs were found to be differentially expressed in the GDM placentas. The biological relationships of the miRNA/mRNA pairs were related to cellular development and function and organ morphology. Among the aberrantly expressed molecules, we selected miR-138-5p from the bioinformatics analysis and found that miR-138-5p significantly inhibited the migration and proliferation of trophoblasts (HTR-8/SVneo) by targeting the 3’-UTR of TBL1X. Furthermore, the aberrant expression of miR-138-5p and TBL1X was significantly correlated with the weight of the placenta. Conclusion: We present the first integrative analysis of miRNA and mRNA expression profiles in GDM placenta and uncover a more detailed role for miR-138-5p, as well as its target TBL1X in the pathology of GDM.

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“…The different microRNAs expressions during pregnancy suggest that they have specific functions at each stage [79]. One of the roles of microRNAs in the placenta is to regulate the growth of the placenta by the growth of trophoblast cells and their apoptosis which is directly linked to the development of the fetus.…”

Section: Placenta Associated With Diabetes Mellitusmentioning

confidence: 99%

“…As regulators of gene expression [79], microRNAs are also produced in the placentas. The different microRNAs expressions during pregnancy suggest that they have specific functions at each stage [79].…”

Section: Placenta Associated With Diabetes Mellitusmentioning

confidence: 99%

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Endocrine Disruptors and Fetal Programming

Lucchese¹,

Grunow²,

Werner³

et al. 2017

OJEMD

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The concept "fetal programming" shows who still in the intrauterine life, can interfere in factors related to the genesis and development of diseases in childhood, adolescence and adult life. The literature shows that children born to mothers with gestational diabetes mellitus (GDM) are at increased risk for the development of obesity in adulthood, it becomes fundamental to study more about the subject. Obesity is a disease of multifactorial etiology, resulting from complex interactions between genetic and environmental factors. However, the marked increase in its incidence, precocity and severity are not yet fully understood. Several findings suggest that stressor stimuli (e.g. diabetes, nutritional changes) during intrauterine development may promote epigenetic changes, as well as affect mitochondrial metabolism, which may modulate fetal development and predispose to the late development of diseases. Despite the considerable amount of evidence accumulated about intrauterine programming for diseases of adult life, the determinant mechanisms of such programming are not yet clear.

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MicroRNAs in Human Placental Development and Pregnancy Complications

Cited by 224 publications

References 156 publications

miRNAs in pregnancy-related complications

miRNAs in pregnancy-related complications

Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus

Endocrine Disruptors and Fetal Programming

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