MicroRNAs in hematopoietic stem cell aging

Luinenburg, Daniëlle; Haan, Gerald de

doi:10.1016/j.mad.2020.111281

Cited by 11 publications

(16 citation statements)

References 39 publications

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“…Stem cells taken from a donor showing tissue compatibility with the recipient (allogeneic transplant) or the patient (autologous transplant) may be used here. In the second case, the problematic deficit of suitable donors, the risk of rejection, or complications resulting from prolonged intake of immunosuppressants preventing recoil are avoided [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Section: Introductionmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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“…Several miRNAs have been identified, which influence the regulations of these different states of HSC (36). Several of them (miR-21, miR-22, miR-99, miR-125a/b and miR-155, reviewed in Luinenburg et al (36) are target genes in the mTOR pathway (37).…”

Section: Discussionmentioning

confidence: 99%

“…Several miRNAs have been identified, which influence the regulations of these different states of HSC (34,36) by the mTOR pathway (37,38).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes

Jani

Petkau

Kawano

et al. 2023

Preprint

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The microRNA cluster-221/222 is expressed in hematopoietic stem cells (HSC) and multipotent progenitors (MPP). To study its function in hematopoiesis, we generated mice, in which this cluster is selectively deleted by Vav-cre in HSC and, thus, in all hematopoietic cells. Fluorescence-activated cell sorting analyses of the lineage-negative HSC and MPP compartments in bone marrow at unperturbed, steady state hematopoiesis detect strong activation of HSC to MPP, as well as increased granulocytes in the periphery, induced by miR-221/222-deficiency. Short-term social stress on mice also activates HSC to MPP, but the time of stress is too short to detect further increases in granulocyte numbers. Single cell deep mRNA sequencing identifies Fos as direct, and Jun as well as six other immediate early genes (IEG) as indirect targets of miR-221/222 at unperturbed hematopoiesis. Three of these IEG - Klf6, Nr4a1 and Zfp36 - have previously been found to influence myelo/granulopoiesis. Short stress induces higher levels of the same, and an even larger number of IEGs, now also in MPP, indicating, that stress and miR-221/222 both activate HSC to MPP by IEG upregulation in perturbed hematopoiesis. Furthermore, combined stress and miR-221/222-deficiency rapidly increase numbers of myelo/granulocyte progenitors (MEP, GMP) in bone marrow. Additional indirect miR-221/222-targets become detectable in MPP, of which H3f3b has previously been found to influence myelopoiesis. In serial transplantations, miR-221/222-deficient HSC retain their capacity to home to, and become resident in bone marrow, but they loose their lymphopoietic capacities, thus their multipotency. Our results suggest, that miR-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating the expression of IEG and of myelo/granulopoiesis-enhancing target genes. Since miR-221/222 is also expressed in human HSC and MPP, its expression should improve clinical settings of human bone marrow transplantations.

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“…The final fate of HSCs differentiation is highly regulated by the interaction between this kind of cells with surrounding cellular elements, genomic factors, and microenvironmental conditions that arise in response to hematopoietic demands under normal and pathological circumstances (infectious and inflammatory processes) [ 30 , 32 , 33 , 34 , 35 ]. MiRNAs are among the main modulators of the expression of genes involved in the regulation of cell-differentiation programs [ 32 , 36 , 37 , 38 ]. Gene expression analysis in purified hematopoietic populations has shown that specific miRNAs can regulate the differentiation and maturation stages of distinct hematopoietic cell lines [ 32 , 36 , 38 , 39 , 40 ].…”

Section: Mirnas and Hematopoiesismentioning

confidence: 99%

MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia

Mendiola-Soto

Bárcenas-López

Pérez-Amado

et al. 2023

IJMS

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Acute lymphoblastic leukemia (ALL) is the most common kind of pediatric cancer. Although the cure rates in ALL have significantly increased in developed countries, still 15–20% of patients relapse, with even higher rates in developing countries. The role of non-coding RNA genes as microRNAs (miRNAs) has gained interest from researchers in regard to improving our knowledge of the molecular mechanisms underlying ALL development, as well as identifying biomarkers with clinical relevance. Despite the wide heterogeneity reveled in miRNA studies in ALL, consistent findings give us confidence that miRNAs could be useful to discriminate between leukemia linages, immunophenotypes, molecular groups, high-risk-for-relapse groups, and poor/good responders to chemotherapy. For instance, miR-125b has been associated with prognosis and chemoresistance in ALL, miR-21 has an oncogenic role in lymphoid malignancies, and the miR-181 family can act either as a oncomiR or tumor suppressor in several hematological malignancies. However, few of these studies have explored the molecular interplay between miRNAs and their targeted genes. This review aims to state the different ways in which miRNAs could be involved in ALL and their clinical implications.

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MicroRNAs in hematopoietic stem cell aging

Cited by 11 publications

References 39 publications

Collagen-Based Materials Modified by Phenolic Acids—A Review

Collagen-Based Materials Modified by Phenolic Acids—A Review

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes

MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia

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