MicroRNAs in endothelial cell homeostasis and vascular disease

Fernández‐Hernando, Carlos; Suárez, Yajaira

doi:10.1097/moh.0000000000000424

Cited by 81 publications

(63 citation statements)

References 130 publications

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“…Certain tissue-and "cell-specific" miRNAs have been clearly shown to be expressed in/and associated with cardiovascular settings and involve in maintaining vascular integrity [30]. Emerging evidence suggests that any changes or disruption into the arterial flow modulate the expression profiles of miRNAs of varied cells of luminal wall [31,32]. Studies have shown that several flow-sensitive miRNAs including miR-21, miR-23b, miR-92a, miR-19a, miR-143, miR-145, and miR-155, miR-205, miR-126 are directly or indirectly involved in the pathophysiological mechanism of atherosclerosis and therefore identified as mechano-miRs [31].…”

Section: Discussionmentioning

confidence: 99%

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Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease

Kumar

Narang

Sreenivas

et al. 2020

Genes

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While coronary artery disease (CAD) has become a major threat worldwide, the timely biomarker-based early diagnosis of CAD remains a major unmet clinical challenge. We aimed towards assessing the level of circulatory microRNAs as candidates of novel biomarkers in patients with CAD. A total of 147 subjects were recruited which includes 78 subjects with angiographically proven CAD, 15 pre-atherosclerotic normal coronary artery (NCA) subjects and 54 healthy individuals. Quantitative real-time PCR assays were performed. MiR-133b was downregulated by 4.6 fold (p < 0.0001) whereas miR-21 was upregulated by ~2 fold (p < 0.0001) in plasma samples of CAD patients. Importantly, both the miRNAs showed association with disease severity as miR-133b was downregulated by 8.45 fold in acute coronary syndrome (ACS), 3.38 fold in Stable angina (SA) and 2.08 fold in NCA. MiR-21 was upregulated by 2.46 fold in ACS, 1.90 fold in SA and 1.12 fold in NCA. Moreover, miR-133b could significantly differentiate subjects with ST-elevation myocardial infarction (STEMI) from Non-STEMI. Area under the curve (AUC) for miR-133b was 0.80 with >75.6% sensitivity and specificity, AUC for miR-21 was 0.79 with >69.4% sensitivity and specificity. Our results suggest that miR-133b and miR-21 could be possible candidates of novel biomarkers in early prediction of CAD.

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Section: Discussionmentioning

confidence: 99%

“…Recently, researchers also tried to identify the role of miR-21 in AMI patients [43] but also addressed the limitation of its "cardiac specificity", as miR-21 is involved in multiple organs. This issue can certainly be overcome by using it in combination with other miRNA signatures as diagnostic markers as shown by other studies [32,44].…”

Section: Discussionmentioning

confidence: 99%

Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease

Kumar

Narang

Sreenivas

et al. 2020

Genes

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“…Moreover, some mediators, such as miRNAs, are described to have a critical role in (patho)physiological processes, including atherosclerosis [70][71][72]. In particular, miR-126 exerts an atheroprotective effect [72,73] due to its role in restoring endothelium homeostasis [74].…”

Section: The Physio-pathological Role Of Hif In Agingmentioning

confidence: 99%

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Alique

Sánchez-López

Bodega

et al. 2020

Cells

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Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.

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“…MicroRNAs (miRs) are post‐transcriptional regulators of gene expression that have been implicated as a novel class of molecules important in maintaining arterial health and mediating cardiovascular responses to exercise (Bartel, (2018); Donaldson, Lao, & Zeng, 2018; Fernández‐Hernando & Suárez, 2018; Lee & Chiu, 2019; Nanoudis, Pikilidou, Yavropoulou, & Zebekakis, 2017; Sapp, Shill, Roth, & Hagberg, 2017; Sapp & Hagberg, 2019). Circulating miRs (ci‐miRs) released from cells into the bloodstream are proposed as novel biomarkers and mediators of cardiovascular exercise responses, as well as CVD (Johnson, 2019; Njock & Fish, 2017; Sapp & Hagberg, 2019; Sapp et al., 2017,).…”

Section: Introductionmentioning

confidence: 99%

Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

et al. 2020

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High-intensity interval (HII) exercise elicits distinct vascular responses compared to a matched dose of moderate intensity continuous (MOD) exercise. However, the acute effects of HII compared to MOD exercise on arterial stiffness are incompletely understood. Circulating microRNAs (ci-miRs) may contribute to the vascular effects of exercise. We sought to determine exercise intensity-dependent changes in ci-miR potentially underlying changes in arterial stiffness. Ten young, healthy men underwent well-matched, 30-min HII and MOD exercise bouts. RT-qPCR was used to determine the levels of seven vascular-related ci-miRs in serum obtained immediately before and after exercise. Arterial stiffness measures including carotid to femoral pulse wave velocity (cf-PWV), carotid arterial compliance and β-stiffness, and augmentation index (AIx and AIx75) were taken before, 10min after and 60min after exercise. Ci-miR-21-5p, 126-3p, 126-5p, 150-5p, 155-5p, and 181b-5p increased after HII exercise (p < .05), while ci-miR-150-5p and 221-3p increased after MOD exercise (p = .03 and 0.056). One hour after HII exercise, cf-PWV trended toward being lower compared to baseline (p = .056) and was significantly lower compared to 60min after MOD exercise (p = .04). Carotid arterial compliance was increased 60min after HII exercise (p = .049) and was greater than 60min after MOD exercise (p = .02). AIx75 increased 10 min after both HII and MOD exercise (p < .05).There were significant correlations between some of the exercise-induced changes in individual ci-miRs and changes in cf-PWV and AIx/AIx75. These results support the hypotheses that arterial stiffness and ci-miRs are altered in an exercise intensitydependent manner, and ci-miRs may contribute to changes in arterial stiffness.

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MicroRNAs in endothelial cell homeostasis and vascular disease

Cited by 81 publications

References 130 publications

Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease

Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Changes in circulating microRNA and arterial stiffness following high‐intensity interval and moderate intensity continuous exercise

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