MicroRNAs in cancer metastasis and angiogenesis

Lou, Weiyang; Liu, Jingxing; Gao, Yanjia; Zhong, Guansheng; Chen, Danni; Shen, Jingnan; Bao, Chang; Xu, Liang; Pan, Jie; Cheng, Jie; Ding, Bo; Fan, Weimin

doi:10.18632/oncotarget.23115

Cited by 104 publications

(73 citation statements)

References 160 publications

(167 reference statements)

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“…Besides more traditional signaling factors, research has also focused on the roles of more recently discovered factors such as microRNAs (miRNAs) 20 . These 20-25 nucleotide small non-coding RNA molecules play important signaling roles in various mechanisms of health and disease, such as angiogenesis and carcinogenesis 21–23 . Biogenesis of miRNAs starts in the nucleus where precursor miRNAs are being transcribed.…”

Section: Introductionmentioning

confidence: 99%

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a

Berkhout

Keijser

Repping

et al. 2020

Preprint

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Implantation failure is one of the major success limiting factors in human reproduction. Despite, the mechanisms that determine successful human embryo implantation remain largely unknown. We here show that high-quality human preimplantation embryos secrete soluble signaling factors, including micro RNA (miRNA) hsa-miR-320a, that promote migration of human endometrial stromal cells (hESCs). By using miRNA mimics and inhibitors, we demonstrate that hsa-miR-320a alone can stimulate migration of decidualized hESCs, accurately resembling the response typically triggered only by high-quality embryos. Transcriptome analysis further demonstrated that this effect is very likely mediated via altered expression of genes involved in cell adhesion and cytoskeleton organization. In conclusion, by secreting hsa-miR-320a, high-quality human preimplantation embryos directly influence endometrial stromal cells, most likely to prime the endometrium at the implantation site for successful implantation. Together, our results indicate that hsa-miR-320a may be a promising target to further increase success rates in assisted reproduction.

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Section: Introductionmentioning

confidence: 99%

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a

Berkhout

Keijser

Repping

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Over one-half of the characterized miRNAs are located in genomic regions associated with oncogenes, suggesting that miRNAs may serve important roles in carcinogenesis and cancer progression (12). An increasing number of previous studies have demonstrated that miRNAs are dysregulated in approximately all types of human malignancy, including ccRCC (13)(14)(15). miRNA (miR)-19a (16), miR-224 (17), miR-1274a (18) and miR-543 (19) were upregulated in ccRCC, whereas, miR-30a (20), miR-200a (21), miR-384 (22) and miR-411 (23) were downregulated.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑663 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells by directly targeting PAK4

2018

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Accumulating evidence has demonstrated that microRNAs (miRNAs) are key gene regulators and are abnormally expressed in clear cell renal cell carcinoma (ccRCC). The dysregulation of miRNAs has been implicated in the initiation and progression of ccRCC. Therefore, identification of ccRCC-associated miRNAs may facilitate the determination of promising therapeutic targets for anti-cancer treatment.In the present study, miRNA-663 (miR-663) expression was downregulated in ccRCC tissues and cell lines. Functional experiments suggested that restoration of miR-663 expression inhibited the proliferation and invasion of ccRCC cells. In addition, p21 activated kinase 4 (PAK4) was validated as a direct target of miR-663 in ccRCC cells. PAK4 was upregulated in ccRCC tissues, and the expression level of PAK4 was inversely correlated with the miR-663 expression level. PAK4 restoration partially attenuated the suppressive roles of miR-663 overexpression on the proliferation and invasion of ccRCC cells. The present results provide novel insight into the mechanism underlying the occurrence and development of ccRCC, suggesting that the miR-663/PAK4 axis may be a novel therapeutic target for treatment of patients with ccRCC.

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“…As a class of small endogenous nonprotein-coding RNAs, microRNAs (miRNAs) suppress cellular protein expression by binding the 39-untranslated regions (39-UTRs) of target mRNAs (5,6). Accumulating evidence has shown that miRNAs play key roles in multiple physiologic and pathologic processes, including cancer initiation, progression, and metastasis.…”

mentioning

confidence: 99%

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

et al. 2018

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Accumulating evidence has indicated that microRNAs (miRNAs) play an important role in the occurrence and progression of ovarian cancer (OC). However, the function of miRNAs implicated in OC remains unclear. This study investigated the potential role of miR-211 in OC. Gene Expression Omnibus database analysis indicated that miR-211 expression was significantly down-regulated in OC tissues compared with normal specimens. In addition, miR-211 overexpression apparently inhibited proliferation, migration, xenograft growth, and induced apoptosis in HEY-T30 and SKOV3 cells. Moreover, PHF19, a component of the polycomb group of proteins, was found to be a direct target of miR-211 based on the luciferase reporter assay and Western blot analysis. Consistently, survival analysis indicated that high PHF19 expression was associated with shorter survival time in patients with OC. Importantly, silence of PHF19 reduced proliferation, induced cell cycle arrest, promoted apoptosis, suppressed migration, and inhibited xenograft growth in SKOV3 cells. Restoration of PHF19 expression markedly reversed the inhibitory effect of miR-211 on OC. Moreover, our results indicate that the long noncoding RNA MALAT1 could sponge miR-211 as a competing endogenous RNA and potentially up-regulate PHF19 expression, thus facilitating the OC progression. These findings suggest that the MALAT1/miR-211/PHF19 axis may act as a key mediator in OC and provide new insight into the prevention of this disease.-Tao, F., Tian, X., Ruan, S., Shen, M., Zhang, Z. miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma.

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MicroRNAs in cancer metastasis and angiogenesis

Cited by 104 publications

References 160 publications

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a

MicroRNA‑663 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells by directly targeting PAK4

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

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