MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

Abstract

The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.

Regulation of Inflammasome by microRNAs in Triple-Negative Breast Cancer: New Opportunities for Therapy

“…MiRNA-derived therapies are based on nucleotide hybridization, so the advantage of using them is that targeted sequences can be easily approached and that they can easily target combinations of RNAs. Although miRNA-based therapy indeed offers many advantages, the method for their delivery still remains a challenging subject [ 161 , 162 , 163 ].…”

Potential utility of miRNAs for liquid biopsy in breast cancer

“…There are anti-angiogenic miRNAs that act as tumor suppressors, e.g., miR-7, miR-29b, miR34a, miR124, miR153, miR141, miR-148a, miR-152-3p, miR-205, miR-497, etc. ( 55 ). miR-155 is found to be abnormally overexpressed in BC tissues and is associated with advanced tumor stages as well as metastasis ( 56 ).…”

“…miR-497 could be considered anti-angiogenic miRNA. Hence, a number of miRNAs are important components of BC angiogenesis which also makes them potential therapeutic targets ( 55 ). miRNAs induce tumor progression or suppression via regulating gene expression implicated in certain signaling pathways.…”

miR-302 Suppresses the Proliferation, Migration, and Invasion of Breast Cancer Cells by Downregulating ATAD2

“…miRNAs modulate gene expression by targeting the 3′-untranslated region (UTR) of target mRNAs [ 23 ]. miRNAs regulate various cellular processes, including proliferation, migration, invasion, and apoptosis, by modulating the expression of target genes [ 24 ]. Accumulating evidence has suggested that abnormal miRNA expression is closely associated with carcinogenesis and the malignant progression of various cancers, including breast cancers, by suppressing the expression of oncogenes and tumor suppressor genes [ 25 ].…”