MicroRNAs association with azoospermia, oligospermia, asthenozoospermia, and teratozoospermia: a systematic review

Daneshmandpour, Yousef; Bahmanpour, Zahra; Hamzeiy, Hamid; Moghaddam, Marziyeh Mazaheri; Moghaddam, Madiheh Mazaheri; Khademi, Bahareh; Sakhinia, Ebrahim

doi:10.1007/s10815-019-01674-9

Cited by 28 publications

(15 citation statements)

References 78 publications

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“…It should be highlighted that azoospermia may be caused by a variety of reasons, including anatomical, iatrogenic or genetic. Numerous genetic disorders may be involved in azoospermia, including microdeletions in the AZF genes, variations in genes mainly involved in meiotic arrest [ 267 ] and miRNAs, including members of the let7 family, which have been associated with embryonic developmental arrest [ 268 ]. It has been reported that besides azoospermia, microdeletions in the AZF genes may be responsible for cases of severe oligozoospermia and oligoasthenoteratzoospermia (OAT), while the latter has been associated with autosomal translocations [ 269 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research

Sfakianoudis¹,

Maziotis

Karantzali

et al. 2021

IJMS

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Developmental arrest of the preimplantation embryo is a multifactorial condition, characterized by lack of cellular division for at least 24 hours, hindering the in vitro fertilization cycle outcome. This systematic review aims to present the molecular drivers of developmental arrest, focusing on embryonic and parental factors. A systematic search in PubMed/Medline, Embase and Cochrane-Central-Database was performed in January 2021. A total of 76 studies were included. The identified embryonic factors associated with arrest included gene variations, mitochondrial DNA copy number, methylation patterns, chromosomal abnormalities, metabolic profile and morphological features. Parental factors included, gene variation, protein expression levels and infertility etiology. A valuable conclusion emerging through critical analysis indicated that genetic origins of developmental arrest analyzed from the perspective of parental infertility etiology and the embryo itself, share common ground. This is a unique and long-overdue contribution to literature that for the first time presents an all-inclusive methodological report on the molecular drivers leading to preimplantation embryos’ arrested development. The variety and heterogeneity of developmental arrest drivers, along with their inevitable intertwining relationships does not allow for prioritization on the factors playing a more definitive role in arrested development. This systematic review provides the basis for further research in the field.

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Section: Resultsmentioning

confidence: 99%

Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research

Sfakianoudis¹,

Maziotis

Karantzali

et al. 2021

IJMS

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“…Asthenozoospermia (or asthenospermia) is a pathologic condition that reduces sperm motility and accounts for nearly 20% of male infertility cases (Daneshmandpour et al, 2020; Kiani et al, 2019). Recent research has found that the expression level of miR‐888‐3p increases significantly in patients with asthenozoospermia (Heidary et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Using microRNAs as molecular biomarkers for the evaluation of male infertility

Asadpour

Chelan

2021

Andrologia

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Infertility is a multiplex disorder in the reproductive system, and men are responsible for more than half of the cases. Nowadays, semen analysis has been considered the critical assessment test to diagnose infertile men; however, it has limitations so that the cause behind infertility in 40% of infertile men is unrevealed. Weaknesses of semen assessment indicate a global need for novel and better diagnostic tools and biomarkers. MicroRNAs are short (about 18–22 nucleotide length) non‐coding RNAs that control most (>60%) of our protein‐coding genes post‐transcriptionally. These molecules are aberrant in the body fluids, and abnormal alterations in their expression level can signify a specific disease such as infertility. Therefore, microRNAs can be novel candidate biomarkers that can diagnose different types of male infertility, including azoospermia, oligozoospermia, asthenozoospermia and teratozoospermia. This narrative review aimed to collect and sum up new papers published about the significant role of microRNAs in different male infertility categories.

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“…Oligospermia is a common finding in men with infertility and refers to semen with low sperm concentrations. Most specimens with low sperm concentrations have significant abnormalities in morphology and motility [2]. Male infertil-ity due to oligozoospermia and azoospermia is associated with some genetic risk factors [3].…”

Section: Introductionmentioning

confidence: 99%

Spata19 Inactivation as a Cause of Oligospermia

et al. 2021

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Background: Spermatogenesis associated 19 (Spata19) was introduced as a testis-specific gene that was probably involved in spermatogenesis cell apoptosis. Therefore, this study aimed to investigate the effect of Spata19 inactivation on sperm count. Materials and Methods: We generated global Spata19 knockout mice by CRISPR/Cas9 nickase technology. Disability was validated in three levels of DNA, RNA, and protein using PCR, RT-PCR, and immunohistochemistry. Histological studies were performed for testis. Sperm characteristics were also assessed with CASA software. Results: Spata19 knockout mice had a 43 nucleotides deletion in exon 4 of this gene. The presence and absence of Spata19 were confirmed in normal and knockout mice, respectively. The presence of Spata19 in normal NMRI mice was detected in the brain, heart, and thymus by semi-nested RT-PCR and in Leydig cells by immunohistochemistry. Histological studies revealed a decrease in sperm count in knockout mice. Also, CASA parameters were significantly reduced (P<0.05). Conclusion: These data indicate that Spata19 inactivation is a cause of oligospermia, and its role could be beyond an adhesive molecule.

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MicroRNAs association with azoospermia, oligospermia, asthenozoospermia, and teratozoospermia: a systematic review

Cited by 28 publications

References 78 publications

Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research

Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research

Using microRNAs as molecular biomarkers for the evaluation of male infertility

Spata19 Inactivation as a Cause of Oligospermia

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