MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer

Letelier, Pablo; Saldías, Rolando; Loren, Pía; Riquelme, Ismael; Guzmán, Neftalí

doi:10.3390/ijms242316984

Cited by 5 publications

(4 citation statements)

References 219 publications

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“…All primary mutation types, involving single nucleotide variations, deletions, rearrangements, insertions, and copy number alterations can be found using cancer-personalized profiling by deep sequencing (CAPP-Seq). It’s crucial to bear in mind that CAPP-Seq has limitations regarding the types of mutations it can discover ( 16 , 25 ). Whole genome sequencing (WGS) is a comprehensive approach that examines a tumor’s complete genomic content, which can greatly aid therapeutic decision-making and reveal novel therapy plans, unusual mutations, and invisible oncogenes.…”

Section: Technologies For Ctcs、ctdna and Ev Detectionmentioning

confidence: 99%

“…EVs contain cargoes of miRNAs,mRNAs, and proteins. It has been shown that microRNAs carried by EVs are associated with colorectal cancer ( 14 ), hepatocellular carcinoma ( 15 ), lung cancer ( 16 ), oral cancer ( 17 ), and ovarian cancer ( 18 ). The contents of EVs such as mRNA can promote epithelial-mesenchymal transition and chemoresistance in colorectal cancer ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

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Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Wang,

Lin

et al. 2024

Front. Oncol.

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Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vehicles (EVs) have received significant attention in recent times as emerging biomarkers and subjects of transformational studies. The three main branches of liquid biopsy have evolved from the three primary tumor liquid biopsy detection targets—CTC, ctDNA, and EVs—each with distinct benefits. CTCs are derived from circulating cancer cells from the original tumor or metastases and may display global features of the tumor. ctDNA has been extensively analyzed and has been used to aid in the diagnosis, treatment, and prognosis of neoplastic diseases. EVs contain tumor-derived material such as DNA, RNA, proteins, lipids, sugar structures, and metabolites. The three provide different detection contents but have strong complementarity to a certain extent. Even though they have already been employed in several clinical trials, the clinical utility of three biomarkers is still being studied, with promising initial findings. This review thoroughly overviews established and emerging technologies for the isolation, characterization, and content detection of CTC, ctDNA, and EVs. Also discussed were the most recent developments in the study of potential liquid biopsy biomarkers for cancer diagnosis, therapeutic monitoring, and prognosis prediction. These included CTC, ctDNA, and EVs. Finally, the potential and challenges of employing liquid biopsy based on CTC, ctDNA, and EVs for precision medicine were evaluated.

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Section: Technologies For Ctcs、ctdna and Ev Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Wang,

Lin

et al. 2024

Front. Oncol.

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“…In the context of short-term effects, studies within school populations have identified a decline in lung function, heightened instances of airway inflammation, and an escalated likelihood of developing lung cancer among those consistently exposed to HC over an extended period [10,17]. Nitrogen oxides (NOx)…”

Section: Hydrocarbons (Hc)mentioning

confidence: 99%

Reducing emissions of harmful substances in rally cars

Urbański,

Przybyła,

Brodziński

et al. 2024

Combustion Engines

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Currently discussed changes in the automotive sector, which are aimed at significantly reducing emissions of harmful substances in road transport, also affect the directions of development of motorsport. One of them is the use of electric drive systems. Currently produced electric cars are not technically prepared to compete in car rallies, both due to their performance and safety reasons. For this reason, rallies still use combustion engines and attempts are made to implement hybrid drive systems. Bearing in mind the above-mentioned limitations of electric drive technology, combustion engines will remain in car rallies for a longer time. Taking the above into account, the article focuses on the issues of exhaust gas treatment systems in rally cars. Tests were carried out to determine exhaust emissions from a car using a catalytic converter approved according to FIA guidelines and compare them to the current standards for mass-produced cars. Thanks to them, it was also possible to estimate the level of exhaust emissions on the approach sections of the car rally. A separate issue was the analysis of how much the use of an electrically driven compressor could reduce fuel consumption by limiting the operation of the ALS system, which is designed to maintain the turbocharger's rotational speed at a constant level. Reducing fuel consumption on the special stage would also have a positive impact on reducing emissions of harmful substances from the rally car.

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“…Currently, the miRBase database ( ; accessed in 1 December 2023) lists over 2588 distinct miRNAs that are involved in nearly every cellular process, highlighting the vast and complex nature of this field of study [ 7 , 8 ]. Moreover, alterations in miRNA expression have been implicated in a myriad of diseases, emphasizing their importance in maintaining cellular homeostasis [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS

Swaminathan,

Rogel-Ayala,

Armich

et al. 2024

Cancers

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The eukaryotic genome is mainly transcribed into non-coding RNAs (ncRNAs), including different RNA biotypes, such as micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), among others. Although miRNAs are assumed to act primarily in the cytosol, mature miRNAs have been reported and functionally characterized in the nuclei of different cells. Further, lncRNAs are important regulators of different biological processes in the cell nucleus as part of different ribonucleoprotein complexes. CircRNAs constitute a relatively less-characterized RNA biotype that has a circular structure as result of a back-splicing process. However, circRNAs have recently attracted attention in different scientific fields due to their involvement in various biological processes and pathologies. In this review, we will summarize recent studies that link to cancer miRNAs that have been functionally characterized in the cell nucleus, as well as lncRNAs and circRNAs that are bound by core components of the polycomb repressive complex 2 (PRC2) or the protein fused in sarcoma (FUS), highlighting mechanistic aspects and their diagnostic and therapeutic potential.

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MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer

Cited by 5 publications

References 219 publications

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Reducing emissions of harmful substances in rally cars

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS

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