MicroRNAs: A Light into the “Black Box” of Neuropediatric Diseases?

Omran, Ahmed; Elimam, Dalia; Shalaby, S.; Peng, Jing; Yin, Fei

doi:10.1007/s12017-012-8193-y

Cited by 17 publications

(9 citation statements)

References 156 publications

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“…They are believed to fine-tune many biological processes, such as developmental timing and tissue differentiation. Moreover, miRNA deregulation has been implicated in various diseases including pediatric chronic, central nervous system (CNS), and cardiovascular diseases, reviewed in [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

microRNA s (9, 138, 181A, 221, and 222) and mesial temporal lobe epilepsy in developing brains

Ashhab

Omran²,

Kong

et al. 2013

Translational Neuroscience

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Background: Recently, microRNAs (miRNAs) have attracted much attention as novel players in the pathogenesis of mesial temporal lobe epilepsy (MTLE) in mature and developing brains. This study aimed to investigate the expression dynamics of miR-9, miR-138, miR-181a, miR-221, and miR-222 in the hippocampus of an immature rat model during the three stages of MTLE development and in children with MTLE. Methodology: qPCR was used to measure expression levels during the three stages of MTLE development (2 h, 3, and 8 weeks after induction of lithium-pilocarpine status epilepticus, representing the acute, latent, and chronic stages, respectively. Expression levels were also measured in hippocampi obtained from children with MTLE and normal controls. Results: In the rat model, miR-9 was significantly upregulated during the acute and chronic stages relative to controls, but not during the latent stage. MiR-138, miR-221 and miR-222 were all downregulated during all three stages of MTLE development. MiR-181a was downregulated during the acute stage, upregulated during the chronic stage, and unaltered during the latent stage. In children, miR-9 and miR-181a were upregulated, while miR-138, miR-221, and miR-222 were downregulated. Conclusion: Modulation of these miRNAs may be a new strategy in designing antiepileptic and anticonvulsant therapies for the developing brain.

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Section: Introductionmentioning

confidence: 99%

microRNA s (9, 138, 181A, 221, and 222) and mesial temporal lobe epilepsy in developing brains

Ashhab

Omran²,

Kong

et al. 2013

Translational Neuroscience

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“…A lot of evidences suggest that miRNAs dysregulations are responsible for many types of human disease, including pediatric central nervous system (CNS), cardiovascular and chronic disorders [6][7][8] .…”

Section: Research Highlightmentioning

confidence: 99%

Inflammation-related and Brain-enriched MicroRNAs Influence the Activation of Microglia Response to In vitro Oxygen-Glucose Deprivation

Kong¹,

Omran²,

Aly³

et al. 2014

Inflamm Cell Signal

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Microglia is one of the major resident immunecompetent cells in the central nervous system (CNS) and has become an important cellular component for understanding brain diseases. MicroRNAs (miRNAs) are small, noncoding RNAs molecules that regulate expression of protein-coding mRNAs on the post-transcriptional level; miRNAs plays important roles in microglial activation in response to brain ischemia and other stressors. Through culturing primary rat microglial cells and establishing a microglial activation model by oxygenglucose deprivation (OGD). We found that the viability of the microglia was time-dependent and expressions of inflammation-related miRNAs (miR-146a, -21, -181a, -221, and -222), and brain-enriched miRNAs (miR-124, -134, -9, -132, and -138) in microglia were modulated in an OGD model of ischemic insult. This research highlight discusses the findings of the recent study and the investigators' active research endeavors.

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“…Attention has been recently drawn to the role of miRNAs in pediatric CNS diseases [2], including epilepsy, shedding new light on the molecular mechanism promising novel therapeutic targets and effective antiepileptogenic medications.…”

Section: Mirnas and Epilepsymentioning

confidence: 99%

“…The list of diseases in which dysregulation of miRNAs has been implicated is constantly growing and includes major pediatric chronic non-neoplastic diseases. We recently reviewed the role of miRNAs in pediatric central nervous system and cardiovascular diseases including congenital heart diseases [2, 3]. This review summarizes recent progress in edge-cutting research about the involvement of miRNAs in bronchial asthma, diabetes mellitus, epilepsy, and cystic fibrosis (Table 1).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs: New Insights into Chronic Childhood Diseases

Omran

Elimam

Yin

2013

BioMed Research International

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Chronic diseases are the major cause of morbidity and mortality worldwide and have shown increasing incidence rates among children in the last decades. Chronic illnesses in the pediatric population, even if well managed, affect social, psychological, and physical development and often limit education and active participation and increase the risk for health complications. The significant pediatric morbidity and mortality rates caused by chronic illnesses call for serious efforts toward better understanding of the pathogenesis of these disorders. Recent studies have shown the involvement of microRNAs (miRNAs) in various aspects of major pediatric chronic non-neoplastic diseases. This review focuses on the role of miRNAs in four major pediatric chronic diseases including bronchial asthma, diabetes mellitus, epilepsy and cystic fibrosis. We intend to emphasize the importance of miRNA-based research in combating these major disorders, as we believe this approach will result in novel therapies to aid securing normal development and to prevent disabilities in the pediatric population.

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MicroRNAs: A Light into the “Black Box” of Neuropediatric Diseases?

Cited by 17 publications

References 156 publications

microRNA s (9, 138, 181A, 221, and 222) and mesial temporal lobe epilepsy in developing brains

microRNA s (9, 138, 181A, 221, and 222) and mesial temporal lobe epilepsy in developing brains

Inflammation-related and Brain-enriched MicroRNAs Influence the Activation of Microglia Response to In vitro Oxygen-Glucose Deprivation

MicroRNAs: New Insights into Chronic Childhood Diseases

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