MicroRNA23a and MicroRNA23b Deregulation Derepresses SF-1 and Upregulates Estrogen Signaling in Ovarian Endometriosis

Shen, Licong; Yang, Shiyuan; Huang, Wei; Xu, Wenming; Wang, Qiushi; Song, Yong; Liu, Ying

doi:10.1210/jc.2012-3010

Cited by 50 publications

(37 citation statements)

References 26 publications

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“…However, Saare et al (2014) found that miR-200b was upregulated in such tissues. In addition, miR-20a plays an important role in the pathogenesis of ovarian endometriosis by suppressing NTN4 (Zhao et al, 2014), miR23a and miR23b are potential biomarkers of ovarian endometriosis (Shen et al, 2013), and miR196b targets c-myc and Bcl-2 expression, inhibiting proliferation and inducing apoptosis in endometriotic stromal cells (Abe et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Teng

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA expression was quantified using a microRNA array and reversetranscription microRNA polymerase chain reaction. Levels of vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor 2 (EGFR2), phosphatase and tensin homolog (PTEN), and C-X-C chemokine receptor type 4 (CXCR4) were quantified using enzyme-linked immunosorbent assay. The endometrial tissue showed significantly lower levels of miR-200b, miR-15a-5p, miR-19b-1-5p, miR-146a-5p, and miR-200c, and higher levels of miR-16-5p, miR106b-5p, and miR-145-5p. VEGFA was significantly upregulated, whereas EGFR2, PTEN, and CXCR4 were markedly downregulated, in the endometriotic tissues compared to that in the normal endometrial tissues. In conclusion, differences in the miRNA levels could modulate the expression of VEGFA, EGFR2, PTEN, and CXCR4, and may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in the eutopic endometrium might facilitate the implantation of endometrial cells at ectopic sites.

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Section: Discussionmentioning

confidence: 99%

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Teng

et al. 2016

Genet. Mol. Res.

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“…SF-1 plays an important role in the development and differentiation of steroidogenic tissues (73). miR-23a and miR-23b deregulation inhibits SF-1 and enhances estrogen signaling in ovarian endometriosis (74). Because miRs themselves are transcriptionally regulated by RNA polymerase II, they can also be regulated by some transcription factors.…”

Section: Discussionmentioning

confidence: 99%

Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins

Yin

Wang

Yao

et al. 2014

Journal of Biological Chemistry

128

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Background: MicroRNAs are small noncoding RNAs associated with ovarian follicle development and female fertility. Results: miR-320 inhibited estradiol synthesis and proliferation of granulosa cells (GCs) through targeting E2F1 and SF-1 in vivo and in vitro. Conclusion: E2F1/SF-1 mediated miR-320-induced suppression of GC proliferation and of GC steroidogenesis. Significance: These will potentiate the usefulness of miRNA in the treatment of some steroid-related disorders.

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“…В очагах эндометриоза присутствие SF-1 может приводить к увеличенной продукции эстрогенов [65]. Экспрессия SF-1 подавлялась сверх-экспрессией miR23a/b в эутопических эндометри-альных стромальных клетках и повышалась при ин-гибировании miR23a/b в нормальных эндометриаль-ных стромальных клетках [66]. Эти данные под-тверждались иммуногистохимически: уровень бел-ков SF-1 и StAR (steroidogenic acute regulatory protein) был значительно выше в эктопической эндометри-альной ткани по сравнению с нормальным эндоме-трием.…”

Section: гормональные факторыunclassified

‘Omic’ high-throughput technologies in research on pathogenesis of endometriosis: a Review

Tikhonchuk¹,

Nepsha²,

Adamyan³

et al. 2016

Probl. reprod.

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MicroRNA23a and MicroRNA23b Deregulation Derepresses SF-1 and Upregulates Estrogen Signaling in Ovarian Endometriosis

Abstract: MiR23a and miR23b are potential biomarkers of ovarian endometriosis. This study provides a novel approach for targeting the mechanisms controlling aberrant local estrogen biosynthesis in endometriosis.

Cited by 50 publications

References 26 publications

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins

‘Omic’ high-throughput technologies in research on pathogenesis of endometriosis: a Review

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