MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue

Малек, Анастасия Валерьевна; Bershtein, L. M.

doi:10.17650/2313-805x.2015.2.1.004-012

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…Короткие одноцепочечные РНК (микроРНК) участвуют в посттранскрипционной экспрессии различных генов. Искажение работы этой системы происходит в процессе злокачественной трансформации, а потом и терапии опухоли [60], и микроРНК могут служить биомаркерами устойчивости к лечению [61]. Другие эпигенетические механизмы модификации экспрессии гена ESR1 включают в себя гиперметилирование CpG (CpG-островки генома) в промоторах и повышенную активность гистондеацетилазы [62].…”

Section: рис 3 действие препаратов для лечения рака молочной железы на мишени сигнальных путей клетки Er -эстрогеновый рецептор; Rtk -рецunclassified

LYN kinase and estrogen receptor ERα: involvement in carcinogenesis and potential therapeutic target for tumors

2021

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Primary or secondary resistance is an important problem when treating any type of tumor. It is often associated with changes in target genes’ functioning. This raises the question of understanding functional intracellular interactions of genes and proteins in oncological processes and therapeutic resistance occurring. When searching target proteins of targeted therapy, it is necessary to identify biomolecules, participating in cell signaling life, which differ significantly in normal and oncological processes and interact with a large number of pathways. It is also important that these biomolecules are not an artifact of tumor therapy or cell line cultivation, and that it is possible to influence them directly, obtaining complex effect. In addition, it is important to study changes occurring during therapy with the biomolecules, which include proto-oncogene of SRC family kinase LYN and gene of the estrogen receptor α ESR1. All these factors may help to overcome the emerging resistance.Objective – to study the way genes of SRC kinase LYN and estrogen receptor α ESR1 influence oncological processes and occurrence of therapeutic resistance.

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LYN kinase and estrogen receptor ERα: involvement in carcinogenesis and potential therapeutic target for tumors

2021

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“…miRNA profile in DU-145 and LNCaP cells. Using the resource http://mirbase.org, we have chosen a panel of micro-RNAs involved in the oncogenesis of human PC and in regulation of the expression of steroid hormones receptors (miRNA-205 and miRNA-155), intercellular adhesion proteins (miRNA-200b), proliferative (miRNA-133a) and invasive (miRNA-205) activity [18,19]. According to our data ( Fig.…”

Section: Phenotypic Characteristics Of Du-145 and Lncap Cellsmentioning

confidence: 99%

EFFECTS OF EXOGENOUS LACTOFERRIN ON PHENOTYPIC PROFILE AND INVASIVENESS OF HUMAN PROSTATE CANCER CELLS (DU-145 AND LNCaP) IN VITRO

Borikun

et al. 2018

Exp. Onc.

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Aim: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. Materials and Methods: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis. The levels of miRNAs were assessed using q-PCR. The invasive activity of the cells was examined in a standard invasion test. Results: Exogenous LF reduced expression of steroid hormone receptors (ERα and PR) and Ki-67 in both PC cell lines. The expression of E-cadherin increased significantly in LF-treated DU-145 cells. Also, we established the decrease in invasive activity upon LF treatment by 40% and 30% in DU-145 and LNCaP cells, respectively. In DU-145 cells, incubation with exogenous LF resulted in an increase in the expression of oncosuppressive (miR-133a and miR-200b) miRNAs. Conclusions: Exogenous LF causes the changes in phenotypic characteristics of PC cells and levels of oncogenic and oncosuppressive miRNAs involved in the regulation of key cellular processes.

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To the Question of Differential Diagnosis of T Cell Skin Lymphomas

Olisova

Amshinskaya

Anpilogova

2019

Russian Journal of Skin and Venereal Diseases

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Cutaneous T cell lymphomas (CTCL) are a clinically and morphologically heterogeneous group of cutaneous malignant tumors, caused by monoclonal proliferation of lymphoid tissue cells in the skin. They are responsible for about 80% of all primary cutaneous lymphomas, while cutaneous lymphomas are responsible for 2% of all dermatological diseases. The incidence of CTCL is now increasing all over the world. For this reason, CTCL has to be diagnosed on the early stage to improve course of the disease. Mycosis fungoides, the most frequent CTCL variant, is usually diagnosed basing on clinical, histological, immunohistochemical and molecular findings. However, it can imitate other chronic dermatoses, which makes it difficult to diagnose. The article presents a review of the current literature data on new diagnostic markers of cutaneous T-cell lymphomas.

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MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue

Cited by 5 publications

References 40 publications

LYN kinase and estrogen receptor ERα: involvement in carcinogenesis and potential therapeutic target for tumors

LYN kinase and estrogen receptor ERα: involvement in carcinogenesis and potential therapeutic target for tumors

EFFECTS OF EXOGENOUS LACTOFERRIN ON PHENOTYPIC PROFILE AND INVASIVENESS OF HUMAN PROSTATE CANCER CELLS (DU-145 AND LNCaP) IN VITRO

To the Question of Differential Diagnosis of T Cell Skin Lymphomas

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