MicroRNA regulation of autophagy in cardiovascular disease

Ma, Sermersheim; Park, Ki Ho; Gumpper, Kristyn; Tm, Adesanya; Song, Kuncheng; Tan, Tao; Ren, Xiaomin; Yuan, Jian‐Min; Zhu, Haijing

doi:10.2741/4471

Cited by 26 publications

(9 citation statements)

References 133 publications

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“…FOXO3a, a pro-autophagitic factor, is negatively regulated by both miR-212 and miR-132. Over expression of miR-212 and miR-132 significantly disturbs autophagy and results in drastic cardiac hypertrophy and heart failure [ 69 , 89 ]. Additionally, the energy sensing pathway of AMPK can be blocked by disruption of the α1 subunit (AMPKα1), and activation of miR-148b directly inhibits its expression [ 90 ], thereby blocking the entire AMPK assembly.…”

Section: Mirnas In Cardiovascular Diseasesmentioning

confidence: 99%

A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update

Islas

Moreno-Cuevas

2018

IJMS

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In this review, we summarize the latest research pertaining to MicroRNAs (miRs) related to cardiovascular diseases. In today’s molecular age, the key clinical aspects of diagnosing and treating these type of diseases are crucial, and miRs play an important role. Therefore, we have made a thorough analysis discussing the most important candidate protagonists of many pathways relating to such conditions as atherosclerosis, heart failure, myocardial infarction, and congenital heart disorders. We approach miRs initially from the fundamental molecular aspects and look at their role in developmental pathways, as well as regulatory mechanisms dysregulated under specific cardiovascular conditions. By doing so, we can better understand their functional roles. Next, we look at therapeutic aspects, including delivery and inhibition techniques. We conclude that a personal approach for treatment is paramount, and so understanding miRs is strategic for cardiovascular health.

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Section: Mirnas In Cardiovascular Diseasesmentioning

confidence: 99%

A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update

Islas

Moreno-Cuevas

2018

IJMS

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“…Macroautophagy involves the formation of double-membrane-bound vesicles called autophagosomes that engulf cytoplasmic proteins and organelles; these autophagosomes are trafficked to lysosomes for degradation 24,25 . The physiological significance of miRNA-autophagy interconnection in human diseases such as cancer and cardiovascular diseases has been documented in recent years 26,27 . The first link established between miRNAs and autophagy showed that miR-30a directly targets Beclin-1 resulting in decreased autophagic activity in cancer cells 28 .…”

Section: Introductionmentioning

confidence: 99%

Synchronized Orchestration of miR-99b and let-7g Positively Regulates Rotavirus Infection by Modulating Autophagy

Mukhopadhyay

Chanda

Patra

et al. 2019

Sci Rep

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Rotavirus (RV), the major etiological agent of viral gastroenteritis in young children, kills over 200 thousand infants each year. In spite of available vaccines, rotaviral diarrhoea is still a major problem in developing countries of Asia and Africa. Therefore, the studies on RV infection and host antiviral responses are warranted. The active correlation between virus infection and activation of autophagy machinery and positive influence of autophagy on RV replication have been documented recently. Previous study from our group showed dysregulation of several cellular miRNAs during RV infection, though their significance remained largely unknown. Since cellular microRNAs (miRNAs) have been implicated in the control of several fundamental biological processes including stress response and autophagy, we focused on two miRNAs, miR-99b and let-7g, and analyzed their function to gain insight into the miRNA-autophagy crosstalk during RV infection. This study shows that RV suppresses let-7g expression but enhances miR-99b that in turn augment major autophagy regulators. Ectopic expression of let-7g and knockdown of miR-99b resulted in inhibition of autophagy, hence, reduction of RV replication. Overall, our study highlights new mechanistic insights for understanding the role of miRNAs in modulating RV infection and possibility of using RNA interference as an antiviral therapeutic target.

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“…MiRNAs participate in multiple biological processes, including autophagy [79-81]. Recent studies have shown that miR-423-5p is upregulated in serum of HCC patients treated with sorafenib and higher expression of secretory miR-423-5p is correlated with an improved prognosis.…”

Section: Autophagy and Cancermentioning

confidence: 99%

Multiple Roles of Autophagy in the Sorafenib Resistance of Hepatocellular Carcinoma

Sun¹,

Liu²,

Ming³

2017

Cell Physiol Biochem

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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and prognosis remains unsatisfactory since the disease is often diagnosed at the advanced stages. Currently, the multikinase inhibitor sorafenib is the only drug approved for the treatment of advanced HCC. However, primary or acquired resistance to sorafenib develops, generating a roadblock in HCC therapy. Autophagy is an intracellular lysosomal pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. Current understanding of the role of autophagy in the progression of cancer and the response to cancer therapy remains controversial. Sorafenib is able to induce autophagy in HCC, but the effect of autophagy is indistinct. Some studies established that sorafenib-induced autophagy serves as a pro-survival response. However, other studies found that sorafenib-induced autophagy improves the lethality of sorafenib against HCC cells. The mechanisms underlying autophagy and sorafenib resistance remain elusive. The purpose of this review is to summarize the progress of research focused on autophagy and sorafenib resistance and to update current knowledge of how cellular autophagy impacts sorafenib sensitivity in HCC treatment.

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MicroRNA regulation of autophagy in cardiovascular disease

Cited by 26 publications

References 133 publications

A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update

A MicroRNA Perspective on Cardiovascular Development and Diseases: An Update

Synchronized Orchestration of miR-99b and let-7g Positively Regulates Rotavirus Infection by Modulating Autophagy

Multiple Roles of Autophagy in the Sorafenib Resistance of Hepatocellular Carcinoma

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