MicroRNA Polymorphisms in Cancer: A Literature Analysis

Pipan, Veronika; Zorc, Minja; Kunej, Tanja

doi:10.3390/cancers7030863

Cited by 32 publications

(16 citation statements)

References 25 publications

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“…Clearly distinguishing between subgroups of patients who have a high or low risk of relapse, treatment resistance and metastasis remains a challenge (22), therefore there is an urgent need to identify biomarkers that can be used to identify patients that require more aggressive postoperative treatment. m iR NAs a re deregulated in numerous human cancers (23,24). Previous studies have demonstrated that miRNAs are reliable and cost-effective biomarkers that can be utilized in the diagnosis and assessment of the progression, therapeutic response and prognosis of a wide spectrum of malignant tumors, including esophageal cancer (7,(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Liu¹,

Wang²,

Liu³

et al. 2017

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Liu¹,

Wang²,

Liu³

et al. 2017

Oncology Letters

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“…The position of miR-SNPs included pri-, pre-, and/or mature miRNA, and the function of the miR-SNPs depended on its position [ 27 ]. The pre-miR-SNPs included hsa- mir-146a rs2910164, hsa- mir-196a-2 rs11614913, hsa- mir-499 rs3746444, hsa- mir-149 rs2292832, and hsa- mir-27a rs895819.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis

Wang

Jiang

2018

Bioscience Reports

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MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic review with a meta-analysis for the association of miRNA SNPs with HCC risk. Thirty-seven studies were included with a total of 11821 HCC patients and 15359 controls in this meta-analysis. We found hsa-mir-146a rs2910164 was associated with a decreased HCC risk in the recessive model (P=0.017, OR = 0.90, 95% confidence interval (CI) = 0.83–0.98). While hsa-mir-34b/c rs4938723 was related with an increased HCC risk in the co-dominant model (P=0.016, odds ratio (OR) = 1.19, 95%CI = 1.03–1.37). When analyzing the Hepatitis B virus (HBV)-related HCC risk, hsa-mir-196a-2 rs11614913 was associated with a decreased HBV-related HCC risk in the co-dominant and allelic models. And hsa-mir-149 rs2292832 was found to be associated with a decreased HBV-related HCC risk in the dominant and recessive models. In conclusion, hsa-mir-146a rs2910164 and hsa-mir-34b/c rs4938723 could be biomarkers for the HCC risk while hsa-mir-196a-2 rs11614913 and hsa-mir-149 rs2292832 had potential to be biomarkers for HBV-related HCC risk.

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“…Unlike many other diseases, such as infectious diseases, that have a particular cause, most cancers are often the consequences of several factors including genetic/epigenetic features and lifestyle factors (Ambrosone, Hong, & Goodwin, 2015). Recently, researchers have been interested in the role of microRNAs (miRNAs) and their polymorphism in breast cancer (Bachour & Bennett, 2011;Pipan, Zorc, & Kunej, 2015).…”

Section: Introductionmentioning

confidence: 99%

The protective role of rs56103835 against breast cancer onset in the Iranian population

Naderi

Peymani

Ghaedi

2019

Molec Gen & Gen Med

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Background Breast cancer is one of the most common types of cancer among women and the highest cause of death due to cancer among women aged 40–45. SNPs can be used to identify disease‐related genes such as cancer as they can be genetic markers. Furthermore, SNPs in the molecular‐level miRNA structure are also associated with a set of cancers. Studies have shown that miR‐323b plays a tumor suppressor role by reducing the tissues and serum of the affected individuals. So far, no study regarding rs56103835 polymorphism in the precursor of miR‐323b has been conducted in the breast cancer. In this study, the association of this SNP with the incidence of breast cancer in the Iranian population has been investigated. Method In order to correlate rs56103835 polymorphism with breast cancer, 161 patients and 162 healthy people as the control group were examined. They had been homogenized based on their age and gender. The genotype of individuals for the polymorphism was determined by the PCR‐RFLP method. The association of this polymorphism with the risk of breast cancer, the age of the onset of disease, and pathological characteristics of the patients was then analyzed. Results The findings showed that there is no significant correlation between the frequency of its genotypes among the healthy and patient populations while the TT genotype increased the age of the disease in patients, as compared to other genotypes ( p = 0.035, OR = 0.487). Discussion and Conclusion The C allele is likely to inhibit the expression of BRCA2 by interfering with the processing of this pre‐miRNA and increasing the expression of target genes such as BRCA2. Because one of the early onset genes in breast cancer is the BRCA2 , the presence of any of C and T alleles can have a significant effect on the incidence of the disease. To further confirm this data, however, more molecular studies are needed.

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MicroRNA Polymorphisms in Cancer: A Literature Analysis

Cited by 32 publications

References 25 publications

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Low expression of miR-1469 predicts disease progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell cancer

Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis

The protective role of rs56103835 against breast cancer onset in the Iranian population

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