The protective role of rs56103835 against breast cancer onset in the Iranian population

Abstract

Background Breast cancer is one of the most common types of cancer among women and the highest cause of death due to cancer among women aged 40–45. SNPs can be used to identify disease‐related genes such as cancer as they can be genetic markers. Furthermore, SNPs in the molecular‐level miRNA structure are also associated with a set of cancers. Studies have shown that miR‐323b plays a tumor suppressor role by reducing the tissues and serum of the affected individuals. So far, no study regarding rs56103835 polymorphism in the precursor of miR‐323b has been conducted in the breast cancer. In this study, the association of this SNP with the incidence of breast cancer in the Iranian population has been investigated. Method In order to correlate rs56103835 polymorphism with breast cancer, 161 patients and 162 healthy people as the control group were examined. They had been homogenized based on their age and gender. The genotype of individuals for the polymorphism was determined by the PCR‐RFLP method. The association of this polymorphism with the risk of breast cancer, the age of the onset of disease, and pathological characteristics of the patients was then analyzed. Results The findings showed that there is no significant correlation between the frequency of its genotypes among the healthy and patient populations while the TT genotype increased the age of the disease in patients, as compared to other genotypes ( p = 0.035, OR = 0.487). Discussion and Conclusion The C allele is likely to inhibit the expression of BRCA2 by interfering with the processing of this pre‐miRNA and increasing the expression of target genes such as BRCA2. Because one of the early onset genes in breast cancer is the BRCA2 , the presence of any of C and T alleles can have a significant effect on the incidence of the disease. To further confirm this data, however, more molecular studies are needed.

Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms

“…The full texts of the remaining 79 records were evaluated and 10 articles were excluded for the following reasons: insufficient reported data ( n : 4) [16,17,18,19], studying other genes or polymorphisms ( n : 3) [20,21,22], not a case-control design ( n : 2) [23,24], and a duplicate study ( n : 1) [25]. Finally, a total of 69 articles remained [26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85<...>…”

Imbalance of Molecular Module of TINCR-miR-761 Promotes the Metastatic Potential of Early Triple Negative Breast Cancer and Partially Offsets the Anti-Tumor Activity of Luteolin

“…Breast cancer (BC) is one of the most common cancers among women aged 40–45 years, and is also one of the important causes of cancer-related deaths among women. 1 At present, the risk of BC is still on the rise, and triple negative breast cancer (TNBC), as a highly invasive phenotype of BC, has a higher risk of death. 2 , 3 The main features of TNBC are high recurrence rate, high metastasis rate and high mortality rate, and its tumor metastasis potential has a key impact on the prognosis of early TNBC patients.…”

A genetic variant of pri‐miR‐182 may impact the risk for the onset of multiple sclerosis in the Iranian population

“…Single‐nucleotide polymorphisms (SNPs), the most common type of variation in the human genome, may occur in nonprotein coding genes, such as the miRNA coding gene or its host gene or pri‐ or pre‐miRNA. Accumulating evidence has indicated that SNPs in miRNA precursors can alter the expression, maturation, and stability of miRNA, and affect the target mRNA binding affinity and specificity (Naderi, Peymani, & Ghaedi, 2019; Suresh, Venkatesh, & Tsutsumi, 2016; Zou et al, 2016). Therefore, these variants may represent an important risk determinant of MS susceptibility and may help explore the mechanisms of the disease (Li, Du, Wang, Ma, & Gui, 2015).…”