MicroRNA (miRNA) and the immune system

Hukowska-Szematowicz, Beata; Tokarz–Deptuła, Beata; Deptuła, Wiesław

doi:10.5114/ceji.2012.32730

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Evidence has demonstrated that miRNAs suppress expression of relevant target genes in hematopoietic cells, and subsequently change the differentiation of hematopoietic progenitor cells. miRNAs may also be involved in the functional regulation of hematopoietic stem cells and immune cells (20). MDSCs are immunoregulatory cells originated from hematopoietic stem cells, which may also be regulated by miRNAs.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiles of granulocytic myeloid-derived suppressor cells from mice bearing Lewis lung carcinoma

Jiang

Gao

Hao

et al. 2016

Molecular Medicine Reports

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Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous myeloid cells that can suppress antitumor immunity. MDSCs are divided into granulocytic (G-MDSCs) and monocytic subsets. In the present study, the microRNA profiles of the G-MDSCs were determined and the differential expression of microRNAs between G-MDSCs from tumor-bearing mice and tumor-free mice was examined. The number of G-MDSCs in spleens of Lewis lung carcinoma (LLC)-bearing mice was ~6-fold higher than in spleens of normal mice (13.54±1.74% vs. 2.14±1.44%; P<0.01) and G-MDSCs account for about 72.9% of all MDSCs. The microRNA (miRNA) profiles of the G-MDSCs from spleen of LLC-bearing mice were obtained using a microRNA microarray and compared with their counterparts from spleens of tumor-free mice. A total of 43 miRNAs with >1.3-fold increased or decreased change were differentially expressed between the experimental and control group mice. The levels of nine of these differentially expressed miRNAs, miRNA-468 (miR-486), miR-192, miR-128, miR-125a, miR-149, miR-27a, miR-125b, miR-350 and miR-328, were also analyzed by RT-qPCR to validate the microarray data. The concordance rate between the results tested by the two methods was 88.9%. Bioinformatics analyses revealed that these miRNAs may act on various target genes, including Adar, Pik3r1, Rybp and Rabgap1, to regulate the survival, differentiation and the function of tumor-induced granulocytic MDSCs. The results revealed microRNAs and potential targets that may be vital for regulating survival, differentiation and function of G-MDSCs induced by LLC. Further investigation should be performed to clarify the roles of these microRNAs in regulating LLC-induced granulocytic MDSCs and the target genes that mediate their functions.

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Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiles of granulocytic myeloid-derived suppressor cells from mice bearing Lewis lung carcinoma

Jiang

Gao

Hao

et al. 2016

Molecular Medicine Reports

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“…In cases when such regulation is impaired, autoimmunity develops [32]. In the last twenty years, substantial progress towards understanding the immune mechanism has been made, and it is clear that miRNAs play an important part in this immune regulation [33].…”

Section: The Role Of Mirna In Immune Responsementioning

confidence: 99%

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

Kotyla

Islam

2020

IJMS

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MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.

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“…The proper functioning of individual human organ systems, conditioned by efficient communication between systems and elements of each of these systems, forms the fundamentals of homeostasis. Communication takes place through endo‐, para‐, and autocrine pathways via protein messengers, hormones, neurotransmitters, cytokines, and short RNA molecules (Sikora, Ptak & Bryniarski, 2011; Hukowska‐Szematowicz, Tokarz‐Deptuła & Deptuła, 2012).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil microRNAs

Garley,

Nowak,

Jabłońska

2023

Biological Reviews

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Neutrophils are considered ‘first‐line defence’ cells as they can be rapidly recruited to the site of the immune response. As key components of non‐specific immune mechanisms, neutrophils use phagocytosis, degranulation, and formation of neutrophil extracellular traps (NETs) to fight pathogens. Recently, immunoregulatory abilities of neutrophils associated with the secretion of several mediators, including cytokines and extracellular vesicles (EVs) containing, among other components, microRNAs (miRNAs), have also been reported. EVs are small structures released by cells into the extracellular space and are present in all body fluids. Microvesicles show the composition and status of the releasing cell, its physiological state, and pathological changes. Currently, EVs have gained immense scientific interest as they act as transporters of epigenetic information in intercellular communication. This review summarises findings from recent scientific reports that have evaluated the utility of miRNA molecules as biomarkers for effective diagnostics or even as start‐points for new therapeutic strategies in neutrophil‐mediated immune reactions. In addition, this review describes the current state of knowledge on miRNA molecules, which are endogenous regulators of gene expression besides being involved in the regulation of the immune response.

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MicroRNA (miRNA) and the immune system

Cited by 4 publications

References 25 publications

MicroRNA expression profiles of granulocytic myeloid-derived suppressor cells from mice bearing Lewis lung carcinoma

MicroRNA expression profiles of granulocytic myeloid-derived suppressor cells from mice bearing Lewis lung carcinoma

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

Neutrophil microRNAs

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