MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection

Peng, Jinbiao; Hong, Yang; Zhang, Min; Han, Yanhui; Liu, Dandan; Fu, Zhiqiang; Shi, Yiting; Xu, Jing; Tao, Jianping; Lin, Jiaojiao

doi:10.1016/j.molbiopara.2013.02.001

Cited by 30 publications

(39 citation statements)

References 35 publications

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“…Variations in miRNA profiles during disease progression have been demonstrated in murine models even during very early acute infection (247,248). As the alteration in miRNA expression profiles is often correlated with numerous human diseases, including liver diseases, He et al investigated the serum levels of host miRNAs in mice, rabbits, buffaloes, and humans infected with S. japonicum, and circulating miR-223 was suggested as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy (249).…”

Section: Detection Of Circulating Mirnasmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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Section: Detection Of Circulating Mirnasmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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“…The expression of several host miRNAs was shown to be altered rapidly in the lungs, liver, and spleen of BALB/c mice as early as 10 days post infection with S. japonicum. 124 A broad array of miRNAs in liver was dysregulated and associated with the progression of S. japonicum infection. 125 These results raise the possibility that circulating host miRNAs may be dynamically altered during the course of schistosome infection; this provides an avenue for their development as useful diagnostic and pathogenic biomarkers for schistosomiasis, because of the strong correlation between the expression profile of miRNAs and the status/progression of the disease.…”

Section: Cytokinesmentioning

confidence: 99%

The chronic enteropathogenic disease schistosomiasis

Olveda¹,

Olveda

McManus

et al. 2014

International Journal of Infectious Diseases

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Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method in assessing hepatic morbidity in the hospital setting, but has practical limitations in the field. The potential of non-invasive biological markers, serum antibodies, cytokines, and circulating host microRNAs to diagnose hepatic fibrosis is presently undergoing evaluation. This review provides an update on the recent advances made with respect to gastrointestinal disease associated with chronic schistosomiasis.

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“…Forty-one differentially expressed miRNAs have been identified in comparisons of rats and mice (Han et al, 2015). One hundred sixty-two miRNAs are expressed in M. fortis in mice, with 12 in the liver, 32 in the spleen and 34 in the lung being differentially expressed in M. fortis (Han et al, 2013). These results indicate that some differentially expressed miRNAs may impact the survival and development of the parasite within different hosts.…”

Section: Epigenetic Studies In Schistosomes: What Is Known?mentioning

confidence: 99%

“…These results suggest that circulating miRNAs may serve as important mediators of the pathology of hepatic schistosomiasis. Furthermore, the miRNA profiles in different tissues (liver, spleen, and lung) of S. japonicum -infected mice suggest that miRNAs may be involved in the regulation of several signaling pathways—such as the MAPK, insulin, Toll-like receptor, and TGF-β pathways—during schistosome infection (Han et al, 2013). Inhibition of microRNA-21 can protect mice against lethal schistosome infection by repressing both the IL-13 and transforming growth factor beta 1 (TGFβ1) pathways (Sombetzki et al, 2015).…”

Section: Epigenetic Studies In Schistosomes: What Is Known?mentioning

confidence: 99%

Epigenetics in Schistosomes: What We Know and What We Need Know

Liu

2016

Front. Cell. Infect. Microbiol.

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Schistosomes are metazoan parasites and can cause schistosomiasis. Epigenetic modifications include DNA methylation, histone modifications and non-coding RNAs. Some enzymes involved in epigenetic modification and microRNA processes have been developed as drugs to treat the disease. Compared with humans and vertebrates, an in-depth understanding of epigenetic modifications in schistosomes is starting to be realized. DNA methylation, histone modifications and non-coding RNAs play important roles in the development and reproduction of schistosomes and in interactions between the host and schistosomes. Therefore, exploring and investigating the epigenetic modifications in schistosomes will facilitate drug development and therapy for schistosomiasis. Here, we review the role of epigenetic modifications in the development, growth and reproduction of schistosomes, and the interactions between the host and schistosome. We further discuss potential epigenetic targets for drug discovery for the treatment of schistosomiasis.

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MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection

Cited by 30 publications

References 35 publications

Advances in the Diagnosis of Human Schistosomiasis

Advances in the Diagnosis of Human Schistosomiasis

The chronic enteropathogenic disease schistosomiasis

Epigenetics in Schistosomes: What We Know and What We Need Know

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