MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors

Rizzuti, Mafalda; Filosa, Giuseppe; Melzi, Valentina; Calandriello, Luca; Dioni, Laura; Bollati, Valentina; Bresolin, Nereo; Comi, Giacomo Pietro; Barabino, Silvia M.L.; Nizzardo, Monica; Corti, Stefania

doi:10.1038/s41598-018-28366-1

Cited by 56 publications

(61 citation statements)

References 63 publications

(74 reference statements)

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“…More recently, a study on muscle tissue from ALS patients showed upregulated levels of miR-132 and miR-125b [80]. Studies showed that TDP-43 and FUS can function miR-132 and NF-kB pathway activation in microglia can modulate miR-125b in ALS [79][80][81]. Thus, miRNAs could be a potential strategy in the early diagnosis and treatment of ALS.…”

Section: Bdnf Associated Micrornas In Amyotrophic Lateral Sclerosismentioning

confidence: 99%

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

et al. 2020

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Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed.

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Section: Bdnf Associated Micrornas In Amyotrophic Lateral Sclerosismentioning

confidence: 99%

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

et al. 2020

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“…; Rizzuti et al. ) for example. Future studies will need to tease apart the factors in our collective secretome responsible for rescue, including the factors contained within the exosomes and within the secretome solution, and those factors that may not be involved in rescue (Maguire ,b).…”

Section: Discussionmentioning

confidence: 99%

Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy

Maguire¹,

Paler²,

Green³

et al. 2019

Physiol Rep

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Evidence suggests that adult stem cell types and progenitor cells act collectively in a given tissue to maintain and heal organs, such as muscle, through a release of a multitude of molecules packaged into exosomes from the different cell types. Using this principle for the development of bioinspired therapeutics that induces homeostatic renormalization, here we show that the collection of molecules released from four cell types, including mesenchymal stem cells, fibroblast, neural stem cells, and astrocytes, rescues degenerating neurons and cells. Specifically, oxidative stress induced in a human recombinant TDP ‐43‐ or FUS ‐ tGFP U2 OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP ‐43 stress granules. Furthermore, we also show that the collective secretome rescues cortical neurons from glutamate toxicity as evidenced by increased neurite outgrowth, reduced LDH release, and reduced caspase 3/7 activity. These data are the first in a series supporting the development of stem cell‐based exosome systems therapeutics that uses a physiological renormalization strategy to treat neurodegenerative diseases.

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“…Studies of miRNAs in ALS have been centered in biomarker discovery [232][233][234][235][236][237] and miRNA activity manipulation for therapeutic designs [234,236,238,239]. For example, miR-27a, miR-34a, miR-155, miR-142-5p, and miR-338-3p have been proposed as biomarkers and potential ALS therapeutic targets, directly or indirectly involved in OS [234,236,238,239].…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

et al. 2020

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Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species and the cellular antioxidant capacity. OS plays a central role in neurodegenerative diseases, where the progressive accumulation of reactive oxygen species induces mitochondrial dysfunction, protein aggregation and inflammation. Regulatory non-protein-coding RNAs (ncRNAs) are essential transcriptional and post-transcriptional gene expression controllers, showing a highly regulated expression in space (cell types), time (developmental and ageing processes) and response to specific stimuli. These dynamic changes shape signaling pathways that are critical for the developmental processes of the nervous system and brain cell homeostasis. Diverse classes of ncRNAs have been involved in the cell response to OS and have been targeted in therapeutic designs. The perturbed expression of ncRNAs has been shown in human neurodegenerative diseases, with these changes contributing to pathogenic mechanisms, including OS and associated toxicity. In the present review, we summarize existing literature linking OS, neurodegeneration and ncRNA function. We provide evidences for the central role of OS in age-related neurodegenerative conditions, recapitulating the main types of regulatory ncRNAs with roles in the normal function of the nervous system and summarizing up-to-date information on ncRNA deregulation with a direct impact on OS associated with major neurodegenerative conditions.

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MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors

Cited by 56 publications

References 63 publications

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

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