MicroRNA: A signature for cancer progression

Hussen, Bashdar Mahmud; Hidayat, Hazha Jamal; Salihi, Abbas; Sabir, Dana Khdr; Taheri, Mohammad; Ghafouri‐Fard, Soudeh

doi:10.1016/j.biopha.2021.111528

Cited by 158 publications

(93 citation statements)

References 195 publications

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“…[9][10][11][12] As a class of small non-coding RNAs that are composed of <22 nucleotides, microRNAs (miRNAs and miRs) regulate gene expression at the post-transcriptional level. [12][13][14] These molecules play in a variety of biological processes such as cell proliferation, differentiation, and apoptosis, 12,14 and their dysregulated expression-i.e., up-regulation or down-regulation, 9 has been identified in different tumors. According to their functions, miR-NAs are classified into oncogenes or tumor suppressors.…”

Section: Introductionmentioning

confidence: 99%

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

Mahmoudian

Razmara

Hussen

et al. 2021

Clinical Laboratory Analysis

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Section: Introductionmentioning

confidence: 99%

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

Mahmoudian

Razmara

Hussen

et al. 2021

Clinical Laboratory Analysis

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“…Recent studies suggested that abnormal expression of oncogenes is often caused by aberrant expression of miRNAs. 31 Several miRNAs have been identified as tumor suppressors in liver cancer, and their downregulation in tumors promotes cell proliferation, differentiation, apoptosis, migration, and invasion. Tumor suppressor miRNAs in HCC include miR-29, miR-101, miR-122, miR-124, miR-145, miR-148, miR-193, miR-195, miR-199, miR-206, miR-370, miR-375, and miR-766.…”

Section: Discussionmentioning

confidence: 99%

SPOCD1 regulated by miR-133a-3p promotes hepatocellular carcinoma invasion and metastasis

et al. 2022

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Objective To investigate the tumorigenic role of spen paralogue and orthologue C-terminal domain-containing 1 (SPOCD1) in hepatocellular carcinoma (HCC) and identify the upstream regulatory mechanism. Methods We analyzed SPOCD1 and miR-133-3p expression in normal and HCC tissues from the Cancer Genome Atlas and UALCAN databases, and in normal hepatocytes and HCC cell lines by real-time quantitative polymerase chain reaction and western blot. We identified the miR-133a-3p-binding site on the SPOCD1 3ʹ-untranslated region using TargetScan. Hierarchical regulation was confirmed by luciferase assay and miR-133a-3p overexpression/silencing. Cell proliferation, migration, invasion, and colony formation were assessed by MTT, scratch, transwell, and clonogenic assays, respectively. Results SPOCD1 was highly expressed in HCC tissues and cell lines, while miR-133a-3p expression was significantly downregulated. Kaplan–Meier analysis indicated that high SPOCD1 expression was significantly associated with poor survival. TargetScan and luciferase reporter assay revealed that SPOCD1 was the downstream target of miR-133a-3p. Overexpression of miR-133a-3p significantly inhibited the expression of SPOCD1, while miR-133a-3p knockdown significantly increased SPOCD1 expression. Conclusion SPOCD1, regulated by miR-133a-3p, promotes HCC cell proliferation, migration, invasion, and colony formation. This study provides the first evidence for the role of the miR-133a-3p/SPOCD1 axis in HCC tumorigenesis.

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“…It is well-known that alteration of transcriptional activators and repressors and abnormal DNA methylation modification of miRNA genomic loci often causes an aberrant miRNA expression profile in cancer (Hussen et al, 2021). In addition to the genomic alterations and patterns of methylation of the miRNA gene sequence, dysregulation of the proteins implicated the miRNA biogenesis contributes to the alterations of miRNA expression in cervical cancer (Ali Syeda et al, 2020).…”

Section: Dysregulation Of Mirnas In Cervical Cancermentioning

confidence: 99%

Cervical Cancer, Papillomavirus, and miRNA Dysfunction

Bañuelos-Villegas¹,

Perez-Y-Perez²,

Álvarez-Salas³

2021

Front. Mol. Biosci.

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Cervical cancer is the leading cause of death by cancer in women from developing countries. Persistent infection with high-risk human papillomavirus (HPV) types 16 and 18 is a major risk factor for cervical carcinogenesis. Nevertheless, only a few women with morphologic expression of HPV infection progress into invasive disease suggesting the involvement of other factors in cervical carcinogenesis. MicroRNAs (miRNAs) are conserved small non-coding RNAs that negatively regulate gene expression including genes involved in fundamental biological processes and human cancer. Dysregulation of miRNAs has been widely reported in cervical cancer. This work focuses on reviewing the miRNAs affected during the HPV infection process, as well relevant miRNAs that contribute to the development and maintenance of malignant cervical tumor cells. Finally, we recapitulate on miRNAs that may be used to distinguish between healthy individuals from patients with precancerous lesions or cervical tumors.

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MicroRNA: A signature for cancer progression

Cited by 158 publications

References 195 publications

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

SPOCD1 regulated by miR-133a-3p promotes hepatocellular carcinoma invasion and metastasis

Cervical Cancer, Papillomavirus, and miRNA Dysfunction

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