MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7

Han, Fei; Chen, Gang; Guo, Yi; Li, Bo; Sun, Yanlong; Qi, Xiangqian; Tian, Hanji; Zhao, Xuebing; Zhang, Honggang

doi:10.3892/ol.2021.12852

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…MiRNAs have been used as markers to predict ovarian cancer sensitivity to platinum and taxane chemotherapeutic agents, which significantly improve treatment outcomes [29]. Some microRNAs are not conducive to cancer outcomes, such as microRNA-4491, which enhances proliferation and inhibits apoptosis in nonsmall cell lung cancer cells [30]. Few studies have assessed the relationship between microRNA-302c and tumors.…”

Section: Discussionmentioning

confidence: 99%

MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1

et al. 2022

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Nasopharyngeal carcinoma (NPC) is one of the most frequent malignant tumors diagnosed in China. Cisplatin is one of the most commonly used anticancer drugs containing platinum in combined chemotherapy. The molecular mechanism of NPC is still largely unknown, and we aim to spare no effort to elucidate it. Normal human nasopharyngeal epithelial cells and NPC cell lines were cultured. The expression levels of miR-302c-5p and HSP90AA1 were detected with quantitative real-time PCR. Western blotting was used to analyze levels of the HSP90AA1, protein kinase B (AKT), p-AKT, CD44 and SOX2 proteins. The interaction between miR-302c-5p and HSP90AA1 was detected using a luciferase reporter assay. The bicinchoninic acid assay was used to observe cisplatin resistance in NPC cells. Our records confirmed that the expression of miR-302c-5p was substantially reduced and HSP90AA1 was increased in NPC cells. Additionally, miR-302c-5p inhibited cisplatin resistance and the traits of stem cells in NPC. A luciferase assay confirmed that miR-302c-5p is bound to HSP90AA1. Overexpression of HSP90AA1 may reverse the effects of overexpressed miR-302c-5p and inhibit cisplatin resistance and stem cell traits of NPC. This study investigated whether miR-302c-5p inhibited the AKT pathway by regulating HSP90AA1 expression and altered the resistance of NPC cells to cisplatin and the traits of tumor stem cells, which has not yet been reported.

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Section: Discussionmentioning

confidence: 99%

MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1

et al. 2022

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“…Han et al showed that miR-4491 was remarkably upregulated in NSCLC cells. Its overexpression facilitated proliferation and repressed apoptosis in NCI-H1650 cells through targeting TRIM7 (118). LncRNAs and circRNAs can also modulate LC proliferation and apoptosis via serving as ceRNAs for miRNA.…”

Section: Ncrna In Lc Proliferation and Apoptosismentioning

confidence: 99%

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Liu,

Ding,

Wang

et al. 2023

Front. Oncol.

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Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth, and early metastasis. The clinical outcomes of LC patients are generally poor due to the insufficient elucidation of pathological mechanisms, low efficiency of detection and assessment methods, and lack of individualized therapeutic strategies. Non-coding RNAs (ncRNAs), including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA), are endogenous regulators that are widely involved in the modulation of almost all aspects of life activities, from organogenesis and aging to immunity and cancer. They commonly play vital roles in various biological processes by regulating gene expression via their interactions with DNA, RNA, or protein. An increasing amount of studies have demonstrated that ncRNAs are closely correlated with the initiation and development of LC. Their dysregulation promotes the progression of LC via distinct mechanisms, such as influencing protein activity, activating oncogenic signaling pathways, or altering specific gene expression. Furthermore, some ncRNAs present certain clinical values as biomarker candidates and therapeutic targets for LC patients. A complete understanding of their mechanisms in LC progression may be highly beneficial to developing ncRNA-based therapeutics for LC patients. This review mainly focuses on the intricate mechanisms of miRNA, lncRNA, and circRNA involved in LC progression and discuss their underlying applications in LC treatment.

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miR-375 Combined with SHOX2 Methylation has Higher Diagnostic Efficacy for Non-Small-Cell Lung Cancer

Zeng

Lin²

2022

Mol Biotechnol

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MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7

Cited by 6 publications

References 38 publications

MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1

MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

miR-375 Combined with SHOX2 Methylation has Higher Diagnostic Efficacy for Non-Small-Cell Lung Cancer

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