MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway

Bao, Jianqiang; Ding, Li; Wang, Li; Wu, Jingwen; Hu, Yanqin; Wang, Zhugang; Chen, Yan; Cao, Xi; Jiang, Cizhong; Yan, Wei; Xu, Chen

doi:10.1074/jbc.m111.328054

Cited by 208 publications

(211 citation statements)

References 60 publications

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“…These findings suggest that miRNAs necessary to confer spermatogonial differentiation may be synthesized by non-canonical enzymes, and the underlying mechanism remains to be elucidated. It has recently been found that miR-449 is predominantly expressed in mouse testes and it is mainly located in spermatocytes and spermatids (Bao et al 2012, Wu et al 2014. Interestingly, miR-34b and miR-34c have been found to resemble the 'seed' sequence of miR-449.…”

Section: Functions Of Mirnas In Meiosis and Spermiogenesismentioning

confidence: 99%

“…Interestingly, miR-34b and miR-34c have been found to resemble the 'seed' sequence of miR-449. Coincidentally, miR-34b and miR-34c exhibit a similar effect to that of miR-449 during the development of male germ cells and spermatogenesis (Bouhallier et al 2010, Bao et al 2012, Wu et al 2014. Individual deficiency in miR-34b/c or miR-449 appears to have no obvious effect; however, simultaneous inactivation of miR-34b/34c and miR-449 leads to mouse oligoasthenoteratozoospermia (Wu et al 2014), implicating that double or triple knockout approach of miRNAs is needed to obtain the phenotype for certain miRNAs.…”

Section: Functions Of Mirnas In Meiosis and Spermiogenesismentioning

confidence: 99%

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MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis

Yao¹,

Liu²,

Sun³

et al. 2015

Reproduction

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Spermatogenesis is composed of three distinctive phases, which include self-renewal of spermatogonia via mitosis, spermatocytes undergoing meiosis I/II and post-meiotic development of haploid spermatids via spermiogenesis. Spermatogenesis also involves condensation of chromatin in the spermatid head before transformation of spermatids to spermatozoa. Epigenetic regulation refers to changes of heritably cellular and physiological traits not caused by modifications in the DNA sequences of the chromatin such as mutations. Major advances have been made in the epigenetic regulation of spermatogenesis. In this review, we address the roles and mechanisms of epigenetic regulators, with a focus on the role of microRNAs and DNA methylation during mitosis, meiosis and spermiogenesis. We also highlight issues that deserve attention for further investigation on the epigenetic regulation of spermatogenesis. More importantly, a thorough understanding of the epigenetic regulation in spermatogenesis will provide insightful information into the etiology of some unexplained infertility, offering new approaches for the treatment of male infertility.Reproduction (2015) 150 R25-R34

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Section: Functions Of Mirnas In Meiosis and Spermiogenesismentioning

confidence: 99%

Section: Functions Of Mirnas In Meiosis and Spermiogenesismentioning

confidence: 99%

MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis

Yao¹,

Liu²,

Sun³

et al. 2015

Reproduction

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“…Noncoding RNA encompass a variety of discrete entities, including micro RNA (miRNA), ultra conserved long non-coding RNA and pyknons. While several miRNA species are regulated via E2F and RB, the mechanisms coordinating such altered expression of miRNA, [11][12][13][14] the targets and overall mode of regulation has remained obscure relative to coding genes.…”

Section: Introductionmentioning

confidence: 99%

Regulation of miR106b cluster through the RB pathway

et al. 2012

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“…Prior to the present study, the data regarding adenocarcinoma was scattered across various databases, including TransmiR (13), computational predicted methods (42), experimentally validated databases (15,16), miRBase (17), the KEGG pathway database (18), the miR2Disease database (19), the GeneCards database (20) and numerous relevant studies (13,(17)(18)(19)(20). The analysis and use of this data is challenging.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been demonstrated that TFs and miRNA may regulate genes (8) and miRNA may regulate target genes (10). In addition, the data of numerous studies have been combined to form various databases, including TransmiR (13), computational predicted methods (14), experimentally validated databases (15,16), miRBase (17), the KEGG pathway database (18), the miR2Disease database (19) and the GeneCards database (20). In these databases, a large amount of data may be found, which was the basis for the present study.…”

Section: Introductionmentioning

confidence: 99%

Construction and analysis of three networks of genes and microRNAs in adenocarcinoma

et al. 2015

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Abstract. Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and the data is stored in a scattered form, making it challenging to summarize and assess the associations between the genes and miRNAs. In the present study, three networks of genes and miRNAs in adenocarcinoma were focused on. This enabled the construction of networks of elements involved in adenocarcinoma and the analysis of these networks, rather than only discussing one gene. Transcription factors (TFs), miRNAs, and target and host genes of miRNAs in adenocarcinoma, and the regulatory associations between these elements were identified in the present study. These elements and associations were then used to construct three networks, which consisted of the differentially-expressed, associated and global networks. The similarities and differences between the three networks were compared and analyzed. In total, 3 notable TFs, consisting of TP53, phosphatase and tensin homolog and SMAD4, were identified in adenocarcinoma. These TFs were able to regulate the differentially-expressed genes and the majority of the differentially-expressed miRNAs. Certain important regulatory associations were also found in adenocarcinoma, in addition to self-regulating associations between TFs and miRNAs. The upstream and downstream elements of the differentially-expressed genes and miRNAs were recorded, which revealed the regulatory associations between genes and miRNAs. The present study clearly revealed components of the pathogenesis of adenocarcinoma and the regulatory associations between the elements in adenocarcinoma. The present study may aid the investigation of gene therapy in adenocarcinoma and provides a theoretical basis for studies of gene therapy methods as a treatment for adenocarcinoma.

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MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway

Cited by 208 publications

References 60 publications

MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis

MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis

Regulation of miR106b cluster through the RB pathway

Construction and analysis of three networks of genes and microRNAs in adenocarcinoma

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