MicroRNA-423 promotes cell growth and regulates G 1 /S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma

Lin, Jun; Huang, Shenglin; Wu, Sen; Ding, Jie; Zhao, Yingjun; Liang, Linhui; Tian, Qiang; Zha, Rujing; Zhan, Rong; He, Xianghuo

doi:10.1093/carcin/bgr199

Cited by 111 publications

(95 citation statements)

References 23 publications

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“…Two miRNAs were newly detected in NSCLC tissue i.e., miR-423-3p and miR-23a-5p, which were underexpressed in the LN group. MiR-423-3p can promote tumor progression through similar signaling pathways as in laryngeal hepatocellular carcinomas [29,30]. It could also be a signature to differentiate hereditary and non-hereditary breast cancers [31].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Xu¹,

Li²,

Li³

et al. 2015

Aging and disease

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Lymph node (LN) metastasis is often an early event in the progression of malignant tumors and it contributes to the majority of cancer mortalities. MiRNAs play key roles in tumor metastasis. This study aimed to investigate the specific miRNAs as putative indicators of metastasis early diagnosis for non-small cell lung cancer (NSCLC). In this study, five NSCLC cases with LN metastasis and four cases without metastasis (NLN) were enrolled for Agilent Human miRNA array. The interested differentially expressed miRNA was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in the LN metastasis (n = 46) and NLN (n = 39) groups. The microarray results revealed that three miRNAs (miR-1260b, miR-423-3p, miR-23a-5p) were differentially expressed in LN metastasis group compared with NLN group. The expression of miR-1260b was tested by qRT-PCR and the mean relative expression fold change (2 -ΔΔCt ) in LN metastasis was significantly higher than that in the NLN group (3.942, 1.743 respectively, P = 1.179E-04). The patients with tumor-node-metastasis (TNM) stage III were identified more frequently in LN metastasis group (P = 1.772E-11) and with a higher expression level of miR-1260b (5.126, P = 1.147E-06). In addition, the LN metastasis cases were associated with a poorly differentiated degree (P = 0.007). The overexpression of miR1260b in NSCLC with LN metastasis can be regarded as a specific signature for early progression and prognosis of NSCLC.

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Section: Discussionmentioning

confidence: 99%

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Xu¹,

Li²,

Li³

et al. 2015

Aging and disease

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“…Cip1/Waf1 (36), and miR-301 inhibits the proliferation and clonogenicity of breast cancer cells through PTEN and FOXF2 (37). Another important characteristic of cancers is metastasis, a complicated, multistep process by which cells detach from the original tissues or organs, migrate into the vascular or lymph circulation, and finally invade another organ, forming a new tumor.…”

Section: Discussionmentioning

confidence: 99%

miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3)

Zhang

Liu

et al. 2013

Journal of Biological Chemistry

128

117

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Background:The role of miR-490-3p in hepatocellular carcinoma (HCC) has not been well clarified. Results: miR-490-3p is up-regulated in HCC and enhances the cell proliferation, migration, invasion abilities, and stimulates the epithelial to mesenchymal transition (EMT) through targeting ERGIC3. Conclusion: miR-490-3p may play an important role in promoting tumor growth and metastasis in HCC. Significance: miR-490-3p may provide beneficial therapeutic strategy for HCC patients.

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“…p53 upregulates the expression of p21, which is known to competitively inhibit cyclin B-CDK1 Remarkably, there are still some miRNAs that act as oncogenic miRNAs and target negative regulators of the G1/S transition of the mitotic cell cycle, such as CIP/ KIP family members, and those miRNAs are upregulated in human HCC and promote the proliferation of HCC cells. For example, p21Cip1/Waf1 was revealed to be a downstream target of miR-423-3p, and it is another miRNA that could notably promote the cell cycle progression at the G1/S transition in HCC cells [56]. Another investigation revealed that CDKN1B/p27 and CDKN1C/p57 were downregulated in HCC cells as direct targets of miR-221; the upregulation of miR-221 can promote cell proliferation and increase the progression to S phase [57].…”

Section: Deregulated Mirnas Involved In the Cell Cyclementioning

confidence: 99%

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Chu

Duan

et al. 2014

Cell Communication and Signaling

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The pathogenesis of hepatocellular carcinoma (HCC) is not fully understood, which has affected the early diagnosis and treatment of HCC and the survival time of patients. MicroRNAs (miRNAs) are a class of evolutionarily conserved small, non-coding RNAs, which regulate the expression of various genes post-transcriptionally. Emerging evidence indicates that the key enzymes involved in the miRNA biosynthesis pathway and some tumor-specific miRNAs are widely deregulated or upregulated in HCC and closely associated with the occurrence and development of various cancers, including HCC. Early studies have shown that miRNAs have critical roles in HCC progression by targeting many critical protein-coding genes, thereby contributing to the promotion of cell proliferation; the avoidance of apoptosis, inducing via angiogenesis; and the activation of invasion and metastasis pathways. Experimental data indicate that discovery of increasing numbers of aberrantly expressed miRNAs has opened up a new field for investigating the molecular mechanism of HCC progression. In this review, we describe the current knowledge about the roles and validated targets of miRNAs in the above pathways that are known to be hallmarks of HCC, and we also describe the influence of genetic variations in miRNA biosynthesis and genes.

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MicroRNA-423 promotes cell growth and regulates G 1 /S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma

Cited by 111 publications

References 23 publications

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

Overexpression of miR-1260b in Non-small Cell Lung Cancer is Associated with Lymph Node Metastasis

miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3)

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

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