MicroRNA-365 targets multiple oncogenes to inhibit proliferation, invasion, and self-renewal of aggressive endometrial cancer cells

Wang, Chunfang; Su, Ke; Zhang, Yanyan; Zhang, Weiwei; Chu, Danxia; Zhao, Qian; Guo, Ruixia

doi:10.2147/cmar.s174889

Cited by 11 publications

(11 citation statements)

References 42 publications

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“…MiRNAs are widely accepted to play critical roles in the progression and metastasis of tumors, such as angiogenesis, 5 chemosensitivity, [6][7][8] cell differentiation and proliferation, 9 tumor invasion and metastasis 10,11 and apoptosis 12,13 . Furthermore, miRNAs may function as "oncogenes" (oncomiRs) or "tumor suppressor genes" in various cancers.…”

Section: Introductionmentioning

confidence: 99%

<p>MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2</p>

Liu

Chen

et al. 2019

CMAR

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Purpose: Clear cell renal cell carcinoma (ccRCC) has the highest rate of metastasis and invasion in RCC and is the third most common adult urinary malignancy. miRNA may serve a critical role in human cancer development and progression, has been confirmed to play a pivotal role in RCC cell invasion and migration. Since miR-935 had been verified to be an oncogene or tumor suppressor in various cancers, the role of miR-935 in RCC was unclear. Methods: Real-time quantitative polymerase chain reaction (qRT-PCR) was used to verify miR-935 expression. CCK-8 assay, wound healing assay and transwell assay were used to investigate the cell proliferation, migration and invasion of miR-935. Receiver operating characteristic (ROC) curve analysis was applied to discriminate different clinical classifications. Gain or loss of function approaches were used to investigate the cell proliferation, migration and invasion of miR-935 in vitro. Bioinformatics analysis and dual-luciferase reporter assay were used to identify the target of miR-935. Results: MiR-935 had a higher expression level in RCC cells and cancer tissues. MiR-935 mimics promoted cell proliferation, migration and invasion, and miR-935 inhibitor inhibited cell inhibit malignancy of cancer cells. Bioinformatics analysis and dual-luciferase reporter assay identified iron-responsive element-binding protein 2 (IREB2) as a direct target of miR-935. qRT-PCR showed IREB2 expression was downregulated in ccRCC cancer tissues and high IREB2 expression had a longer overall survival (OS) and disease-free survival (DFS). Silencing IREB2 could reverse the function of miR-935 inhibitor on cell proliferation and metastasis in renal cancer cells. Conclusion: The study indicated that miR-935 may act as an oncomiRNA and influenced migration and invasion progress of ccRCC by targeting IREB2. Oncogene miR-935 may be a molecular marker and uncover new strategies for ccRCC.

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Section: Introductionmentioning

confidence: 99%

<p>MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2</p>

Liu

Chen

et al. 2019

CMAR

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“…Both EZH2 and FOS were validated as target mRNAs of miR-365, and the upregulation of miR-365 inhibits cell invasion, migration, and survival. Additionally, the sensitivity of cells to paclitaxel is enhanced by miR-365 in endometrial cancer [ 316 ] ( Figure 5 and Table 6 ).…”

Section: Mirnas Regulating the Sensitivity Of Cancer Cells To Phytmentioning

confidence: 99%

Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals

et al. 2020

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Cancer is a global health concern and one of the main causes of disease-related death. Even with considerable progress in investigations on cancer therapy, effective anti-cancer agents and regimens have thus far been insufficient. There has been compelling evidence that natural phytochemicals and their derivatives have potent anti-cancer activities. Plant-based anti-cancer agents, such as etoposide, irinotecan, paclitaxel, and vincristine, are currently being applied in medical treatments for patients with cancer. Further, the efficacy of plenty of phytochemicals has been evaluated to discover a promising candidate for cancer therapy. For developing more effective cancer therapy, it is required to apprehend the molecular mechanism deployed by natural compounds. MicroRNAs (miRNAs) have been realized to play a pivotal role in regulating cellular signaling pathways, affecting the efficacy of therapeutic agents in cancer. This review presents a feature of phytochemicals with anti-cancer activity, focusing mainly on the relationship between phytochemicals and miRNAs, with insights into the role of miRNAs as the mediators and the regulators of anti-cancer effects of phytochemicals.

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“…MiR-365 plays crucial roles in tumor progression in several types of human cancer [87,88,89], but acts as a tumor suppressor in other cancers [90,91,92,93]. Its effect depends on the cellular microenvironment and the specific tumor type; it alters proliferation, apoptosis, migration, and invasion in vitro and in vivo [94,95,96].…”

Section: Onco-mirnas Involved In Cutaneous Squamous Cell Carcinomamentioning

confidence: 99%

“…This miRNA is known to affect various targeted genes, such as NF-I/B [97], BAX [98], Cyclin D1 and BCL-2 [90], FOS , EZH2 and MCL-1 [93], and PIK3R3 [99,100].…”

Section: Onco-mirnas Involved In Cutaneous Squamous Cell Carcinomamentioning

confidence: 99%

MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma

García-Sancha

Corchado-Cobos

Pérez-Losada

et al. 2019

IJMS

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Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and it can be locally invasive and metastatic to distant sites. MicroRNAs (miRNAs or miRs) are endogenous, small, non-coding RNAs of 19–25 nucleotides in length, that are involved in regulating gene expression at a post-transcriptional level. MicroRNAs have been implicated in diverse biological functions and diseases. In cancer, miRNAs can proceed either as oncogenic miRNAs (onco-miRs) or as tumor suppressor miRNAs (oncosuppressor-miRs), depending on the pathway in which they are involved. Dysregulation of miRNA expression has been shown in most of the tumors evaluated. MiRNA dysregulation is known to be involved in the development of cutaneous squamous cell carcinoma (CSCC). In this review, we focus on the recent evidence about the role of miRNAs in the development of CSCC and in the prognosis of this form of skin cancer.

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MicroRNA-365 targets multiple oncogenes to inhibit proliferation, invasion, and self-renewal of aggressive endometrial cancer cells

Cited by 11 publications

References 42 publications

<p>MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2</p>

<p>MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2</p>

Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals

MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma

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