2013
DOI: 10.1038/onc.2013.286
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MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin

Abstract: Accumulating data have shown the involvement of microRNAs in cancerous processes as either oncogenes or tumor suppressor genes. Here, we established miR-30a as a tumor suppressor gene in breast cancer development and metastasis. Ectopic expression of miR-30a in breast cancer cell lines resulted in the suppression of cell growth and metastasis in vitro. Consistently, the xenograft mouse model also unveiled the suppressive effects of miR-30a on tumor growth and distal pulmonary metastasis. With dual luciferase r… Show more

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Cited by 134 publications
(120 citation statements)
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References 52 publications
(62 reference statements)
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“…These bioinformatics strategies might not predict all of the potential targets of microRNAs. What is more, only miRanda and microRNA.org were applied in the study of Baransikin et al In contrast, the prediction results showed that IRS2 was a potential target of miR-30a in the study of Zhang et al (24). Interestingly, miR-30b/miR-30c (miR-30b/c) has a different function from miR-30a even though they share the same seed sequences.…”
Section: Discussionmentioning
confidence: 71%
“…These bioinformatics strategies might not predict all of the potential targets of microRNAs. What is more, only miRanda and microRNA.org were applied in the study of Baransikin et al In contrast, the prediction results showed that IRS2 was a potential target of miR-30a in the study of Zhang et al (24). Interestingly, miR-30b/miR-30c (miR-30b/c) has a different function from miR-30a even though they share the same seed sequences.…”
Section: Discussionmentioning
confidence: 71%
“…6B) as well as cell growth inhibition was clearly visible in RPE-1 cells overexpressing miR-30a, suggesting that ectopic expression of this miRNA was functional and related to the observed tumor suppression. Consequently, miR-30a has been described as a suppressor of tumor growth and inhibitor of cell migration and invasion (Baraniskin et al 2012;Cheng et al 2012;Kumarswamy et al 2012;Zhang et al 2013). Altogether, our results indicate that miR-30b/c and not other miR-30 family members are specifically involved in anoikis resistance.…”
Section: Discussionsupporting
confidence: 66%
“…miR30 family members are among one of the most dysregulated miRNAs in metastatic cancers, each with a potential role in cancer metastasis (21). Although miR30a expression has been reported to be downregulated in metastatic breast cancer and colorectal cancer, its tumor suppressor function is not well understood (22,23). Specifically, downregulation of miR30a in ATC has been previously reported but overexpression of this miRNA did not affect cell proliferation in two ATC cell lines (FRO, FB-1; ref.…”
Section: Discussionmentioning
confidence: 99%