microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS

Zhu, Linan; Wang, Zhiju; Fan, Qingxia; Sun, Yan

doi:10.3892/or.2013.2807

Cited by 35 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MiR‐27a previously showed inconsistent results in various cancers. While serving as a tumour suppressor in oesophageal cancer and liver cancer, it has been reported to be a promoting factor of tumorigenesis in gastric cancer . This was confirmed in our study, where a positive association was seen between miR‐27 and gastric cancer but a negative association with breast cancer.…”

Section: Discussionsupporting

confidence: 89%

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Park

Jeong

Lee

et al. 2020

Eur J Clin Investigation

View full text Add to dashboard Cite

Background Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re‐assessing of significant results in meta‐analyses. We summarized published meta‐analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method We searched PubMed and investigated the results of meta‐analyses published through November 2018. We re‐assessed the results based on false‐positive report probability (FPRP) to test the noteworthiness of the associations. Results Sixty‐eight miRNA polymorphisms in 45 meta‐analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR‐146a/rs2910164 Cvs.G; miR‐27a/rs895819 Cvs.T; miR‐423/rs6505162 Cvs.A; and miR‐605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR‐196a2/rs11614913 Tvs.C; miR‐27a/rs895819 GGvs.AA + AG; miR‐196a2/rs11614913 C vs.T; miR‐146a/rs2910164 Gvs.C; miR‐196a2/rs11614913 Tvs.C; miR‐146a/rs2910164 Cvs.G; miR‐499/rs3746444 homozygous model; miR‐146a/rs2910164 CCvs.GG + GC; miR‐499/rs3746444 TCvs.TT; miR‐499/rs3746444 GAvs.AA; miR‐146a/rs2910164 CCvs.GG; and miR‐499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001. Conclusion Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re‐assessing meta‐analysis. Our findings summarize the results of meta‐analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.

show abstract

Section: Discussionsupporting

confidence: 89%

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Park

Jeong

Lee

et al. 2020

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…In addition, miR‐27a has been shown to negatively regulate FOXO1 , RYBP , and ZBTB10 , which regulate apoptosis and cell cycle progression . In contrast, some studies have reported that miR‐27a functions as a tumor suppressor in esophageal squamous cell carcinoma by regulating KRAS, in renal cell carcinoma by targeting EGFR and in prostate cancer by targeting MAP2K4 . However, miR‐27a functions and target genes in lung cancer are not fully understood.…”

Section: Resultsmentioning

confidence: 99%

MIR‐27a regulates the TGF‐β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer

Chae

Ban

Yoo

et al. 2017

Molecular Carcinogenesis

View full text Add to dashboard Cite

The transforming growth factor-β (TGF-β) signaling pathway is associated with carcinogenesis and various biological processes. SMAD2 and SMAD4, which are putative tumor suppressors, have an important role in TGF-β signaling. The aberrant expression of these genes is implicated in some cancers. However, the mechanisms of SMAD2 and SMAD4 dysregulation are poorly understood. In this study, we observed that miR-27a was upregulated in lung cancer cell lines and patients. In addition, SMAD2 and SMAD4 genes were identified as targets of miR-27a by several target prediction databases and experimental validation. Functional studies revealed that miR-27a overexpression decreased SMAD2 and SMAD4 mRNA and protein levels. Furthermore, miR-27a contributed to cell proliferation and invasion by inhibiting TGF-β-induced cell cycle arrest. These results suggest that miR-27a may function as an oncogene by regulating SMAD2 and SMAD4 in lung cancer. Thus, miR-27a may be a potential target for cancer therapy.

show abstract

“…MiR-27a has been investigated in several types of cancer and comes into inconsistent results. MiR-27a functions as a tumor suppressor in ESCC and hepatocellular carcinoma, while serves as promoting factor in gastric tumorigenesis2930. Therefore, we assume that miR-27a plays pleiotropic signaling roles in regulating tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA sequence polymorphisms and the risk of different types of cancer

Wang

et al. 2014

Sci Rep

View full text Add to dashboard Cite

MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNAs (MirSNPs) might promote carcinogenesis by affecting miRNA function and/or maturation; however, the association between MirSNPs reported and cancer risk remain inconsistent. Here, we investigated the association between nine common MirSNPs and cancer risk using data from large scale case-control studies. Eight precursor-miRNA (pre-miRNA) SNPs (rs2043556/miR-605, rs3746444/miR-499a/b, rs4919510/miR-608, rs2910164/miR-146a, rs11614913/miR-196a2, rs895819/miR-27a, rs2292832/miR-149, rs6505162/miR-423) and one primary-miRNA (pri-miRNA) SNP (rs1834306/miR-100) were analyzed in 16399 cases and 21779 controls from seven published studies in eight common cancers. With a novel statistic, Cross phenotype meta-analysis (CPMA) of the association of MirSNPs with multiple phenotypes indicated rs2910164 C (P = 1.11E-03), rs2043556 C (P = 0.0165), rs6505162 C (P = 2.05E-03) and rs895819 (P = 0.0284) were associated with a significant overall risk of cancer. In conclusion, MirSNPs might affect an individual's susceptibility to various types of cancer.

show abstract

microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS

Cited by 35 publications

References 25 publications

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

MIR‐27a regulates the TGF‐β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer

MicroRNA sequence polymorphisms and the risk of different types of cancer

Contact Info

Product

Resources

About