microRNA‐222 promotes colorectal cancer cell migration and invasion by targeting MST3

Luo, Fei; Zhou, Jianfeng; Wang, Shihua; Sun, Zhao; Han, Qin; Bai, Chunmei

doi:10.1002/2211-5463.12623

Cited by 20 publications

(16 citation statements)

References 35 publications

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“…MicroRNAs (miRNAs/miRs), composed of 19-25 nucleo-/miRs), composed of 19-25 nucleo-miRs), composed of 19-25 nucleotides, are a group of short non-coding endogenous RNA molecules that function as negative regulators on gene expression via binding to the 3' untranslated regions (3'UTRs) of target mRNAs (9,10). Accumulating evidence has suggested that miRNAs are extensively involved in tumor development by participating in biological processes, including cell proliferation, apoptosis, migration and invasion, especially in CRC (11)(12)(13). miR-133a-3p, a member of the miRNA family, has been recently studied for its tumor suppressive role in various cancer types by targeting different related molecules.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑133a‑3p inhibits cell proliferation, migration and invasion in colorectal cancer by targeting AQP1

et al. 2021

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Recently, miR-133a-3p has been identified as a marker for human colorectal cancer (CRC) and the association between miR-133a-3p and aquaporin 1 (AQP1) has been described in endothelial cells. However, the regulatory functions of the miR-133a-3p/AQP1 axis remain unclear in CRC. The present study analyzed the expression of miR-133a-3p and AQP1 in CRC tissues (n=56) and cell lines using reverse transcription-quantitative PCR and western blot analysis. The χ 2 test was used to assess the associations between miR-133a-3p/AQP1 and clinicopathological features of patients with CRC. Next, the functional role of miR-133a-3p/AQP1 in CRC was evaluated in vitro by performing Cell Counting Kit-8 and Transwell assays. Moreover, the online software tool TargetScan7.1 was used to predict AQP1 as the target gene of miR-133a-3p, followed by validation using a luciferase reporter assay. The results showed that miR-133a-3p was significantly downregulated, while AQP1 was upregulated in CRC tissues and cell lines compared with corresponding controls. Clinically, it was demonstrated that miR-133a-3p/AQP1 expression was significantly associated with tumor TNM stage (P=0.020). Functional experiments indicated that miR-133a-3p-overexpression remarkably suppressed, while knockdown promoted, cell proliferation, migration and invasion in CRC cells. Mechanically, AQP1 was identified and validated as a target gene of miR-133a-3p in CRC cells. The expression level of AQP1 mRNA was not correlated with miR-133a-3p expression in CRC tissues. Furthermore, AQP1-knockdown induced, while overexpression reversed, the suppressive effects of miR-133a-3p on CRC cells. Taken together, these findings suggested that miR-133a-3p might be a tumor suppressor by suppressing cell proliferation, migration and invasion via targeting AQP1.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‑133a‑3p inhibits cell proliferation, migration and invasion in colorectal cancer by targeting AQP1

et al. 2021

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“…The AKT signaling pathway also proved to play a role in miR-222-mediated invasion and metastasis of papillary thyroid cancer [220]. As in colon cancer, miR-222 proved to enhance the formation of lung metastasis in thyroid cancer patients [219,220].…”

Section: Mir-222mentioning

confidence: 94%

“…MiR-222 alters the colon cancer cell migration through the downregulation of its target gene mammalian STE20-like protein kinase 3 (MST3) which plays a key role in the phosphorylation of paxillin, thus reducing the intercellular adhesion. Furthermore, miR-222 together with MST3 play a crucial role in the production of inadopodia [219]. Furthermore, the overexpression of miR-222 in aggressive papillary thyroid cancer tissues was established.…”

Section: Mir-222mentioning

confidence: 98%

MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis

Fodor

Lazăr

Buchman

et al. 2021

IJMS

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Metabolic syndrome (MetS) represents a cluster of disorders that increase the risk of a plethora of conditions, in particular type two diabetes, cardiovascular diseases, and certain types of cancers. MetS is a complex entity characterized by a chronic inflammatory state that implies dysregulations of adipokins and proinflammatory cytokins together with hormonal and growth factors imbalances. Of great interest is the implication of microRNA (miRNA, miR), non-coding RNA, in cancer genesis, progression, and metastasis. The adipose tissue serves as an important source of miRs, which represent a novel class of adipokines, that play a crucial role in carcinogenesis. Altered miRs secretion in the adipose tissue, in the context of MetS, might explain their implication in the oncogenesis. The interplay between miRs expressed in adipose tissue, their dysregulation and cancer pathogenesis are still intriguing, taking into consideration the fact that miRNAs show both carcinogenic and tumor suppressor effects. The aim of our review was to discuss the latest publications concerning the implication of miRs dysregulation in MetS and their significance in tumoral signaling pathways. Furthermore, we emphasized the role of miRNAs as potential target therapies and their implication in cancer progression and metastasis.

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“…In colorectal cancer (CRC), miR-222 overexpression increased the migration and invasion of CRC cell lines ( 37 ). miR-29a-3p and miR-200a served as targets for Astaxanthin (AXT), one of the most common carotenoids ( 38 ).…”

Section: Microrna (Mirna) In Invadopodiamentioning

confidence: 99%

Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis

Yang

2021

Front. Oncol.

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Invadopodia are actin-rich structures and their formation is implicated in cancer invasion and metastasis. Growing evidence has shown that noncoding RNAs (ncRNAs) play important roles in pathological conditions, including tumorigenesis and metastasis. Although this is still a new area of research, ncRNAs appear to be promising biomarkers and therapeutic targets for cancer metastasis. However, understanding the roles of ncRNAs in invadopodia is still in the early stages and far from clinical application. In this mini-review, we summarize the roles of ncRNAs in invadopodia functions and discuss them in a therapeutic context. The current challenges and gaps in this field are also raised, and we provide some open questions to facilitate new ideas in targeting invadopodia in anticancer therapy.

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microRNA‐222 promotes colorectal cancer cell migration and invasion by targeting MST3

Cited by 20 publications

References 35 publications

MicroRNA‑133a‑3p inhibits cell proliferation, migration and invasion in colorectal cancer by targeting AQP1

MicroRNA‑133a‑3p inhibits cell proliferation, migration and invasion in colorectal cancer by targeting AQP1

MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis

Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis

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