Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis

Li, Feiya; Yang, Burton B.

doi:10.3389/fonc.2021.681576

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…CircSHPRH was identified to encode a 146 amino acids protein which inhibits tumor growth by stopping ubiquitin proteasome-mediated degradation of SHPRH protein in glioma [ 81 ]. In addition to regulating basic biological processes, circRNAs also play critical roles in the progression of different types of cancers [ 82 , 83 , 84 , 85 , 86 , 87 , 88 ], cardiovascular disorders [ 89 , 90 , 91 ], neuronal degenerative diseases [ 92 , 93 , 94 , 95 ], and other physiological conditions [ 96 , 97 , 98 , 99 , 100 , 101 ]. Due to the high stability of circRNAs, we believe that they can make monumental contributions to the diagnosis and treatment of diseases.…”

Section: Overview Of Circrnasmentioning

confidence: 99%

The Emerging Functions of Circular RNAs in Bladder Cancer

Sun

Wang

Yang

2021

Cancers

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Bladder cancer (BC) is among the top ten most common cancer types worldwide and is a serious threat to human health. Circular RNAs (circRNAs) are a new class of non-coding RNAs generated by covalently closed loops through back-splicing. As an emerging research hotspot, circRNAs have attracted considerable attention due to their high conservation, stability, abundance, and specificity of tissue development. Accumulating evidence has revealed different form of circRNAs are closely related to the malignant phenotype, prognosis and chemotherapy resistance of BC, suggesting that different circRNAs may be promising biomarkers and have therapeutic significance in BC. The intention of this review is to summarize the mechanisms of circRNA-mediated BC progression and their diagnostic and prognostic value as biomarkers, as well as to further explore their roles in chemotherapy resistance.

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Section: Overview Of Circrnasmentioning

confidence: 99%

The Emerging Functions of Circular RNAs in Bladder Cancer

Sun

Wang

Yang

2021

Cancers

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“…Compared to miRNAs, circRNAs are more stable and not easily degraded by exonucleases. CircRNAs are involved in various cancer-related physiological cellular processes and are recognized as potential biomarkers in cancer metastasis ( Li and Yang, 2021 ; Wei et al, 2021 ; Yarmishyn et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers

et al. 2022

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Background: Lung adenocarcinoma (LUAD) has a significant tendency to metastasize to the bone, with severe comorbidities. Recent studies have reported that circular RNAs (circRNAs) are involved in various cancer metastasis-related physiological cellular processes. However, their role in LUAD with bone metastasis (LUAD-BM) remains unknown.Methods: Bone metastasis (BM) circRNAs were identified using high-throughput sequencing and validated by quantitative reverse transcription-PCR (qRT-PCR). Bioinformatic analyses were used to predict the potential functions of the differentially expressed circRNAs. The effects of circ_0096442 on the growth and metastasis of A549 cells were detected in a co-culture system of A549 and bone marrow-derived cells.Results: There were 598 (238 upregulated and 360 downregulated) 390 (187 upregulated and 203 downregulated) and 644 (336 upregulated and 308 downregulated) differentially expressed circRNAs between LUAD-BM and LUAD, LUAD-BM and healthy individuals, and LUAD and healthy individuals, respectively. These differentially expressed circRNAs play important roles in cellular components, biological processes, and molecular functions. Moreover, they map several pathways related to BM, including DNA repair, DNA damage, and osteoclast differentiation. The results validated by qRT-PCR for the five most dysregulated circRNAs are consistent with the sequencing data. Additionally, circ_0096442 was found to promote the growth and metastasis of LUAD in a bone microenvironment.Conclusion: Our findings provide a novel and important circRNA expression profile of LUAD-BM and suggest that circ_0096442 may be a biomarker for LUAD-BM.

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Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer

Perrin

Gligorijevic²

2022

Phys. Biol.

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Cancer invasion and metastasis require remodeling of the adjacent extracellular matrix (ECM). In this mini review, we will cover the mechanisms of proteolytic degradation and the mechanical remodeling of the ECM by cancer cells, with a focus on invadopodia. Invadopodia are membrane protrusions unique to cancer cells, characterized by an actin core and by the focal degradation of ECM via MMPs. While ECM can also be remodeled, at lower levels, by focal adhesions, or internal collagen digestion, invadopodia are now recognized as the major mechanism for MMP-dependent pericellular ECM degradation by cancer cells. Recent evidence suggests that the completion of epithelial-mesenchymal transition (EMT) may be dispensable for invadopodia and metastasis, and that invadopodia is required not only for mesenchymal, single cell invasion, but also for collective invasion. During collective invasion, invadopodia was then shown to be located in leader cells, allowing follower cells to move via cooperation. Collectively, this suggests that invadopodia function may be a requirement not only for later steps of metastasis, but also for early invasion of epithelial cells into the stromal tissue. Over the last decade, invadopodia studies have transitioned into in 3D and in vivo settings, leading to the confirmation of their essential role in metastasis in preclinical animal models. In summary, invadopodia may hold a great potential for individual risk assessment as a prognostic marker for metastasis, as well as therapeutic target.

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Non-Coding RNAs in Invadopodia: New Insights Into Cancer Metastasis

Cited by 3 publications

References 49 publications

The Emerging Functions of Circular RNAs in Bladder Cancer

The Emerging Functions of Circular RNAs in Bladder Cancer

Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers

Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer

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