MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Zhang, Ji‐Guang; Wang, Jianjun; Zhao, Feng; Liu, Quan; Jiang, Ke; Yang, Guanghai

doi:10.1016/j.cca.2010.02.074

Cited by 485 publications

(349 citation statements)

References 45 publications

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“…miR-21 is also mentioned several times in the earlier discussion on pathway targets as being involved in different cancers including pancreas (50), lung (51), and breast (45). Increased miR-21 expression has been shown to be indicative of chemoresistance through 2 pathways.…”

Section: Mir-21: More To the Story?mentioning

confidence: 98%

“…Recent studies have also shown that introducing a miR-21 inhibitor successfully inhibits the targeted functions of the miRNA, increasing levels of PDCD4, and thus decreasing oncogenesis and expression of IAP (inhibitors of apoptosis proteins) and MDR1/P-gp (45). The second pathway is by repression of the tumor suppressor PTEN in NSCLC, which is involved in regulation of cell growth and invasion (51). When functioning correctly, PTEN aids in apoptosis, and in cancers, it helps keep the tumor cells from growing aberrantly (45).…”

Section: Mir-21: More To the Story?mentioning

confidence: 99%

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Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

Allen

Weiss

2010

Molecular Cancer Therapeutics

139

110

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Chemoresistance to many commercially available cancer therapeutic drugs is a common occurrence and contributes to cancer mortality as it often leads to disease progression. There have been a number of studies evaluating the mechanisms of resistance and the biological factors involved. microRNAs have recently been identified as playing a role in the regulation of key genes implicated as cancer therapeutic targets or in mechanisms of chemoresistance including EGFR, MDR1, PTEN, Bak1, and PDCD4 among others. This article briefly reviews chemoresistance mechanisms, discusses how microRNAs can play a role in those mechanisms, and summarizes current research involving microRNAs as both regulators of key target genes for chemoresistance and biomarkers for treatment response. It is clear from the accumulating literature that microRNAs can play an important role in chemoresistance and hold much promise for the development of targeted therapies and personalized medicine. This review brings together much of this new research as a starting point for identifying key areas of interest and potentials for future study.

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Section: Mir-21: More To the Story?mentioning

confidence: 98%

Section: Mir-21: More To the Story?mentioning

confidence: 99%

Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

Allen

Weiss

2010

Molecular Cancer Therapeutics

139

110

View full text Add to dashboard Cite

show abstract

“…It is well established that miRNA may perform different functions through distinct pathways in a way that depends on the context or tissue specificity [12]. A number of investigations have demonstrated that aberrant miRNA expression contributes to NSCLC progression, such as miR-1, let-7 and miR-21 [13][14][15]. However, miRNAs identified in the regulation of LAD progression are limited [16,17].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-29c Functions as a Tumor Suppressor by Targeting VEGFA in Lung Adenocarcinoma

Liu

Wu³

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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“…It has been proved that phosphatase and tensin homologue is the direct target of miR-21 whose expression is elevated in GC tissues (Chan et al, 2008;Zhang et al, 2008). The expression of miR-21 has been reported to be remarkably increased in breast cancer, liver cancer, lung cancer, ovarian cancer and other malignant tumors, and was associated with tumor invasion, metastasis and prognosis (Hiyoshi et al, 2009;Zhang et al, 2010;Zhang et al, 2012). Several studies on gastric cancer demonstrated that miR-21 expression in tumor tissues was significantly higher than non-tumor tissues, and was closely related to tumor size and depth (Motoyanma et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Plasma Post-operative miR-21 Expression in the Prognosis of Gastric Cancers

Gu²,

Zhu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Tumor-associated microRNAs have been detected in serum or plasma, but whether plasma microRNA-21 (miR-21) could be a potential circulating biomarker for gastric cancer (GC) prognosis in Chinese is still uncertain. Real-time quantitative reverse transcription PCR (qRT-PCR) was employed in this study to compare the relative expression of miR-21 between pre-operative and post-operative paired plasmas from 42 patients with primary GCs. The results showed that the expression levels of miR-21 in the post-operative plasmas were significantly reduced by an average of 18.2 times in all patients when compared to the pre-operative plasmas, and by 22.1 times in the subgroup of patients without family history, while only 1.76 times in the subgroup of patients with a family history. With respect of clinicopathological characteristics, the plasma miR-21 expression was highly associated with differentiation degree and lymph node metastasis rate. The results suggested plasma miR-21 could be a novel potential biomarker for GC prognosis and evaluation of surgery outcomes, especially in patients without a family history.

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MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Cited by 485 publications

References 45 publications

Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

Resistance May Not Be Futile: microRNA Biomarkers for Chemoresistance and Potential Therapeutics

MicroRNA-29c Functions as a Tumor Suppressor by Targeting VEGFA in Lung Adenocarcinoma

Plasma Post-operative miR-21 Expression in the Prognosis of Gastric Cancers

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