MicroRNA-21 gene and cancer

Huang, Yong; Yang, You; Zhang, Xiao Hui; Yu, Xue; Wang, Zhan Bin; Cheng, Xiang

doi:10.1007/s12032-012-0376-8

Cited by 89 publications

(62 citation statements)

References 99 publications

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“…has been found to be implicated in almost every cancer network [71][72][73][74]. Taking into account that miR-21 is 22 nt in length, the limiting factor for anti-miRNA POC design is the length of antisense oligonucleotide to form (i) a stable duplex with the target and (ii) to have potential cleavage sites in miR-21.…”

Section: Design Of Mir-21 Targeted Oligonucleotides and Peptide-oligomentioning

confidence: 99%

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

et al. 2017

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Please cite this article as: Patutina OA, Bichenkova EV, Miroshnichenko SK, Mironova NL, Trivoluzzi LT, Burusco KK, Bryce RA, Vlassov VV, Zenkova MA, miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells, Biomaterials (2017Biomaterials ( ), doi: 10.1016Biomaterials ( / j.biomaterials.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Design Of Mir-21 Targeted Oligonucleotides and Peptide-oligomentioning

confidence: 99%

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

et al. 2017

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“…MicroRNAs may act as oncogenes or tumor suppressors involved in the tumorigenesis and aggression of human cancers (59). It was observed in a recent study that Huaier treatment (2-8 mg/ml for 24-72 h) induced cell apoptosis of pulmonary adenocarcinoma A549 cells via upregulation of miR-26b-5p (15), an miRNA known to be significantly downregulated in various types of cancer and to induce apoptosis in cancer cells (60,61).…”

Section: Apoptosis Induction By Huaiermentioning

confidence: 99%

The anticancer effect of Huaier (Review)

Song

Zhang

2015

Oncology Reports

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Abstract. Trametes robiniophila Murr. (Huaier) is a sandy beige mushroom found on the trunks of trees and has been widely used in traditional Chinese medicine (TCM) for ~1,600 years. The anticancer effects of Huaier have attracted increasing worldwide interest in recent years. Accumulating evidence suggests that the anticancer mechanism of Huaier may be associated with various biological activities, such as inhibition of cell proliferation, anti-metastasis, interference with tumor angiogenesis and tumor-specific immunomodulatory effect. Animal and experimental studies suggest that Huaier is a promising anticancer agent. Further clinical research is warranted to illustrate the untapped chemopreventive and therapeutic potential of Huaier either alone or in conjunction with existing therapies.

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“…There is increased expression of miR-421, miR-21, miR-221/222, and miR-106a in gastric cancer, while the expression of miR-124a, miR-128b, miR-148, and miR-129 is reduced (Guo et al, 2009;Konishi et al, 2012). MiRNA-21 was one of the first miRNAs to be discovered in human cells, and its expression is significantly upregulated in different kinds of solid tumors, for instance breast and gastric cancer, and is closely associated with cancer pathogenesis (Huang et al, 2013). MiR-21 expression in gastric cancer tissues is significantly higher than in adjacent tissues.…”

Section: Macrophage-secreted Exosomes Delivering Mirna-21 Inhibitor Cmentioning

confidence: 99%

Macrophage-secreted Exosomes Delivering miRNA-21 Inhibitor can Regulate BGC-823 Cell Proliferation

Wang¹,

Wang²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Exosomes, membranous nanovesicles, naturally carry bio-macromolecules or miRNA and play impoetant roles in tumor pathogenesis. Here, we showed that macrophages cell-derived exosomes can function as vehicles to deliver exogenous miR-21 inhibitor into BGC-823 gastric cancer cells. Exosomes loaded with miR-21inhibitor significantly increased miR-21 levels in BGC-823, but miR-21inhibitor loaded in exosomes exerted an opposite effect. miRNA transfected with exosomes had less cellular toxicity to host cells compared to conventional transfection methods. The miR-21inhibitor loaded exosomes promoted the migration ability and reduced apoptosis of BGC-823 gastric cancer cells. These observations indicate that miR-21 acts as a tumor promoter by targeting the PDCD4 gene and preventing apoptosis of gastric cancer cells through inhibition of PDCD4 expression. Furthermore, exosome -mediated miR-21 inhibitor delivery resulted in functionally more efficient inhibition and less cellular toxicity compared to conventional transfection methods. Similar approaches could be useful in modification of target biomolecules in vitro and in vivo. These findings contribute to our understanding of the functions of miR-21 and exosomes as a carrier for therapy of gastric cancer.

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MicroRNA-21 gene and cancer

Cited by 89 publications

References 99 publications

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells

The anticancer effect of Huaier (Review)

Macrophage-secreted Exosomes Delivering miRNA-21 Inhibitor can Regulate BGC-823 Cell Proliferation

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