MicroRNA-21: A novel therapeutic target in human cancer

Pan, Xuan; Wang, Zhao-xia; Wang, Rui

doi:10.4161/cbt.10.12.14252

Cited by 292 publications

(221 citation statements)

References 84 publications

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“…73 miR-21 is an accepted oncomiR. 133,134 Its expression has been shown to be involved in cellular proliferation, 135,136 apoptosis 135 and autophagy. 137 In addition, its expression is associated with chemoresistance in a variety of cancer cells.…”

Section: Mirs Acting At the Post-transcriptional Level -Direct Regulamentioning

confidence: 99%

The network of P-glycoprotein and microRNAs interactions

et al. 2013

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Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs.

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Section: Mirs Acting At the Post-transcriptional Level -Direct Regulamentioning

confidence: 99%

The network of P-glycoprotein and microRNAs interactions

et al. 2013

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“…, one of the cancer-associated miRNAs, has been shown to have the proto-oncogene activity, which is associated with human tumors (Liu et al, 2011;Ma et al, 2011). MiR-21 expression in a variety of solid tumor tissues was significantly higher than that in normal tissues, and was associated with local invasion and lymph node metastasis (Pan et al, 2010). Several studies on the expression of plasma miR-21 in Chinese has been reported (Chan et al, 2008;Li et al, 2012;Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Plasma Post-operative miR-21 Expression in the Prognosis of Gastric Cancers

Gu²,

Zhu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Tumor-associated microRNAs have been detected in serum or plasma, but whether plasma microRNA-21 (miR-21) could be a potential circulating biomarker for gastric cancer (GC) prognosis in Chinese is still uncertain. Real-time quantitative reverse transcription PCR (qRT-PCR) was employed in this study to compare the relative expression of miR-21 between pre-operative and post-operative paired plasmas from 42 patients with primary GCs. The results showed that the expression levels of miR-21 in the post-operative plasmas were significantly reduced by an average of 18.2 times in all patients when compared to the pre-operative plasmas, and by 22.1 times in the subgroup of patients without family history, while only 1.76 times in the subgroup of patients with a family history. With respect of clinicopathological characteristics, the plasma miR-21 expression was highly associated with differentiation degree and lymph node metastasis rate. The results suggested plasma miR-21 could be a novel potential biomarker for GC prognosis and evaluation of surgery outcomes, especially in patients without a family history.

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“…MicroRNA 21 (miR-21) is overexpressed in most solid malignant neoplasms such as carcinomas of the breast, pancreas, lung, stomach and prostate, and glioblastomas [11,[16][17][18]. miR-21 is involved in tumourigenesis [17], tumour progression [19], and metastasis [20].…”

Section: Introductionmentioning

confidence: 99%

“…Gene silencing is achieved by imperfect or perfect pairing of microRNA with3'UTR of target mRNA thereby resulting in inhibition of translation or degradation, respectively [11,12]. They are transcribed as long transcripts and processed by the enzymes Drosha and Dicer into microRNA duplexes.…”

Section: Introductionmentioning

confidence: 99%

“…The functional strand of the duplex is loaded into the RNA-induced silencing complex enzyme (RISC) for gene silencing [10]. MicroRNAs play a role in diverse biological processes including development, cell growth and apoptosis [11,13,14]. Their expression levels are usually disrupted during malignancy [12], making them crucial regulators of the cell cycle and potential biomarkers for cancer [15].…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA 21 Expression Levels in HIV Negative and HIV Positive Diffuse Large B Cell Lymphoma

Phillips¹,

McGrath²,

Sekar³

et al. 2015

Hereditary Genet

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Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease with various morphological and molecular subtypes. It commonly occurs in the elderly as well as in people infected with HIV. According to the Hans' algorithm DLBCL can be classified prognostically into the favourable germinal centre (GC) subtype and the unfavourable non-GC subtype. The disease tends to be more aggressive in HIV infected individuals. Research on DLBCL has been largely conducted on HIV negative samples and it is still unclear how HIV affects the molecular mechanisms of the disease. We conducted a study to compare the expression levels of miR-21 in HIV negative and HIV positive DLBCL patients. Our results suggest that miR-21 expression levels are higher in HIV positive cases of DLBCL. We did not observe any statistically significant difference in miR-21 levels between DLBCL subtypes in both HIV negative and positive cases. Favourable prognosis in HIV negative patients was associated with high miR-21 expression and the reverse was true in HIV positive patients. In conclusion, our results indicate that HIV infection may affect the expression of miR-21 in DLBCL. This highlights the need for further studies on HIV positive DLBCL as the prognostic significance of miR-21 expression level may differ depending on the HIV status.

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MicroRNA-21: A novel therapeutic target in human cancer

Cited by 292 publications

References 84 publications

The network of P-glycoprotein and microRNAs interactions

The network of P-glycoprotein and microRNAs interactions

Plasma Post-operative miR-21 Expression in the Prognosis of Gastric Cancers

MicroRNA 21 Expression Levels in HIV Negative and HIV Positive Diffuse Large B Cell Lymphoma

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