MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma

Fěng, Fang; Chang, Ruimin; Yu, Lei; Xiong, Lei; Xiao, Shuai; Yang, Hao; Yang, Lian-Yue

doi:10.1016/j.jhep.2015.05.008

Cited by 156 publications

(150 citation statements)

References 31 publications

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“…The expression level of miR-1269a in HCC patients without portal vein tumor embolus was reduced72. In addition, the low expression of miR-125a-5p, miR-128-3p, miR-137, miR-185-5p, miR-188-5p, miR-26a-5p, miR-503-5p and miR-744-5p were detected in HCC tissues compared with their non-tumor livers and were involved in the multi-step processes35363773747576. There were six circulating prognostic biomarker miRNAs reported to be associated with tissue invasion and metastasis, including miR-122-5p, miR-17-5p, miR-182-5p, miR-21-5p, miR-24-3p and miR-331-3p, all of them were up-regulated in the group with low survival rate5661637778.…”

Section: Resultsmentioning

confidence: 99%

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.

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Section: Resultsmentioning

confidence: 99%

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Shen

Lin

Yuan

et al. 2016

Sci Rep

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“…As shown in the present study, miR-18a-5p was differentially expressed in the livers of infected rats, which suggests that vascular smooth muscle cell differentiation may be altered following C. sinensis infection [25]. miRNA-188-5p was significantly decreased in hepatocellular carcinoma, which suppresses tumor cell proliferation and metastasis by directly targeting FGF5 [26]. Therefore, it is tempting to postulate that the downregulation of miR-188-5p partly contributes to the C. sinensis -associated induction of cell proliferation during the development of cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 72%

Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection

Han

Tang

et al. 2016

BMC Infect Dis

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“…The miR-188-5p/LAPTM4B/ phosphoinositide-3 kinase/protein kinase B regulatory network performs an important role in PCa progression and chemotherapeutic drug sensitivity (33). Recently, Fang et al (50) indicated that miR-188-5p was significantly decreased in HCC tissue, and that overexpression of miR-188-5p suppresses tumor cellular proliferation and metastasis by directly targeting fibroblastic growth factor 5 in HCC. However, in the present study, miR-188-5p exhibited an 82.1-fold increase in the plasma of patients with HCC compared with the healthy control.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

Zhang

et al. 2017

Oncology Letters

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Abstract. Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression profiles of 3 patients with HCC with familial aggregation of HCC and HBV infection and 1 healthy volunteer were examined by microarray analysis, in order to identify relevant miRNAs involved in the pathogenesis of HCC with familial aggregation and HBV infection. The results indicated that 26 miRNAs exhibited a ≥20-fold increase or decrease in the plasma of patients with HCC, compared with the healthy control (24 upregulated and 2 downregulated). Among these altered miRNAs, 15 of them have been reported in HCC. The other 11 miRNAs have never been reported in HCC. These differentially-expressed miRNAs may be potential molecular markers for HCC pathogenesis and development.

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MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma

Cited by 156 publications

References 31 publications

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison

Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection

MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

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