MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication Between Kupffer Cells and Regulatory T Cells

Liu, Ningning; Chang, Ching Wen; Steer, Clifford J.; Wang, Xin Wei; Song, Guisheng

doi:10.1053/j.gastro.2021.10.015

Cited by 44 publications

(28 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liu et al. ( 105 ) reported that hydrodynamic injection of miR-15a/16-1 inhibited the progression of HCC in mouse models, inhibited hepatic enrichment of Tregs and accelerated the recruitment of hepatic CD8+ cytotoxic T cells.…”

Section: Ncrnas Regulate Cellular Components Of the Tmementioning

confidence: 99%

The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

Xue

Bao

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

HCC is one of the most common malignant tumors and has an extremely poor prognosis. Accumulating studies have shown that noncoding RNA (ncRNA) plays an important role in hepatocellular carcinoma (HCC) development. However, the details of the related mechanisms remain unclear. The heterogeneity of the tumor microenvironment (TME) calls for ample research with deep molecular characterization, with the hope of developing novel biomarkers to improve prognosis, diagnosis and treatment. ncRNAs, particularly microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), have been found to be correlated with HCC neogenesis and progression. In this review, we summarized the aberrant epigenetic and genetic alterations caused by dysregulated ncRNAs and the functional mechanism of classical ncRNAs in the regulation of gene expression. In addition, we focused on the role of ncRNAs in the TME in the regulation of tumor cell proliferation, invasion, migration, immune cell infiltration and functional activation. This may provide a foundation for the development of promising potential prognostic/predictive biomarkers and novel therapies for HCC patients.

show abstract

Section: Ncrnas Regulate Cellular Components Of the Tmementioning

confidence: 99%

The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

Xue

Bao

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Upregulation of FTX inhibits the conversion of NAFLD to HCC by promoting M1 polarization of KC and provokes another effective target for the treatment of NAFLD-HCC ( 27 ). Taking an RNAi-based approach, microRNA-15a/16-1 attenuates immunosuppression by disrupting CCL22-mediated communication between KCs and Tregs, thus representing an additional potential immunotherapy approach for HCC ( 28 ).…”

Section: Resident Myeloid Immune Cells In the Livermentioning

confidence: 99%

Resident Immune Cells of the Liver in the Tumor Microenvironment

Ding

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

The liver is a central immunomodulator that ensures a homeostatic balance between protection and immunotolerance. A hallmark of hepatocellular carcinoma (HCC) is the deregulation of this tightly controlled immunological network. Immune response in the liver involves a complex interplay between resident innate, innate, and adaptive immune cells. The immune response in the liver is modulated by its continuous exposure to toxic molecules and microorganisms that requires a degree of immune tolerance to protect normal tissue from damage. In HCC pathogenesis, immune cells must balance a dual role that includes the elimination of malignant cells, as well as the repair of damaged liver tissue to maintain homeostasis. Immune response in the innate and adaptive immune systems extends to the cross-talk and interaction involving immune-regulating non-hematopoietic cells, myeloid immune cells, and lymphoid immune cells. In this review, we discuss the different immune responses of resident immune cells in the tumor microenvironment. Current FDA-approved targeted therapies, including immunotherapy options, have produced modest results to date for the treatment of advanced HCC. Although immunotherapy therapy to date has demonstrated its potential efficacy, immune cell pathways need to be better understood. In this review article, we summarize the roles of specific resident immune cell subsets and their cross-talk subversion in HCC pathogenesis, with a view to identifying potential new biomarkers and therapy options.

show abstract

“…Many miRNAs can regulate Th17/Treg cell balance in NAFLD such as miR-29c via interacting with insulin-like growth factor binding protein 1/IGFBP1)[ 55 ]. In addition, other microRNAs such as miR-155[ 56 , 57 ], miR-423-5p[ 58 ], and miR-1246[ 59 ] play important roles in modulating the balance of Tregs with Th17 cells and their functions in liver disease.…”

Section: Important Molecules Mediated Treg Function and Metabolismmentioning

confidence: 99%

Regulatory T cells and their associated factors in hepatocellular carcinoma development and therapy

Zhang¹,

Liu²,

Yang³

2022

WJG

View full text Add to dashboard Cite

Liver cancer is the third leading cause of cancer-related death worldwide with primary type hepatocellular carcinoma (HCC). Factors, including carcinogens, infection of hepatitis viruses, alcohol abuse, and non-alcoholic fatty liver disease (NAFLD), can induce HCC initiation and promote HCC progression. The prevalence of NAFLD accompanying the increased incidence of obesity and type 2 diabetes becomes the most increasing factor causing HCC worldwide. However, the benefit of current therapeutic options is still limited. Intrahepatic immunity plays critically important roles in HCC initiation, development, and progression. Regulatory T cells (Tregs) and their associated factors such as metabolites and secreting cytokines mediate the immune tolerance of the tumor microenvironment in HCC. Therefore, targeting Tregs and blocking their mediated factors may prevent HCC progression. This review summarizes the functions of Tregs in HCC-inducing factors including alcoholic and NAFLD, liver fibrosis, cirrhosis, and viral infections. Overall, a better understanding of the role of Tregs in the development and progression of HCC provides treatment strategies for liver cancer treatment.

show abstract

MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication Between Kupffer Cells and Regulatory T Cells

Cited by 44 publications

References 44 publications

The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

Resident Immune Cells of the Liver in the Tumor Microenvironment

Regulatory T cells and their associated factors in hepatocellular carcinoma development and therapy

Contact Info

Product

Resources

About