MicroRNA-155 and antiviral immune responses

Jafarzadeh, Abdollah; Naseri, Alma; Shojaie, Layla; Nemati, Maryam; Jafarzadeh, Sara; Baghi, Hossein Bannazadeh; Hamblin, Michael R.; Akhlagh, Seyed Amirreza; Mirzaei, Hamed

doi:10.1016/j.intimp.2021.108188

Cited by 36 publications

(35 citation statements)

References 176 publications

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“…Here, we investigated the effect of miRNA-155 on PRV infection. In concordance with most of the previous reports on other viruses ( 41 ), PRV infection also induced the expression of miRNA-155-5p in different cell lines in vitro and various mouse tissues in vivo. Moreover, we found that lncRNA-155 was also inducible by PRV infection.…”

Section: Discussionsupporting

confidence: 92%

“…It is well known that miRNA-155 plays an essential role in various biological processes such as tumor formation, inflammatory response, immunity, and viral pathogenesis ( 5 , 9 , 10 ). Previous studies have shown that those viral infections can induce the expression of miRNA-155, and the inducible miRNA-155 is involved in regulating virus-host interaction ( 9 , 10 , 39 – 41 ). However, the functional involvement of miRNA-155 in the pathogenesis of PRV was poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…It has been widely reported that miRNA-155 functions as an antiviral factor against several viruses, such as IAV ( 29 ), hepatitis B virus ( 32 ), West Nile virus ( 42 ), and infectious bursal disease virus ( 40 ). To some extent, however, proviral functions of miRNA-155 have also been identified ( 41 , 43 , 44 ). Exploring the molecular mechanism underlying miRNA-155 mediated antiviral and pro-viral effects remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

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MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p

Raj

Liao

Cai

et al. 2022

mBio

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Here, we found that lncRNA-155KO mice lacking most of the lncRNA-155 sequences along with pre-miRNA-155, were more susceptible to influenza virus or pseudorabies virus infection than miRNA-155KO mice lacking only 19 bp of the miRNA-155 core sequence without affecting the expression of lncRNA-155, as evidenced by faster body weight loss, poorer survival, and higher viral load, suggesting an additional role of lncRNA-155 in regulating viral pathogenesis besides via processing miRNA-155. Congruously, miRNA-155-deleted lncRNA-155 significantly attenuated the viral infection.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p

Raj

Liao

Cai

et al. 2022

mBio

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“…[ 11 , 12 ] Overall, evidence strongly suggests that miR-155 has a critical role as regulator of inflammation [13] and during most viral infections, since the expression level of miR-155 is upregulated and regulates antiviral immune responses. [14] …”

Section: Introductionmentioning

confidence: 99%

The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease

Abbasi-Kolli

Nahand

Kiani

et al. 2022

The Brazilian Journal of Infectious Diseases

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“…binding to mRNAs and thereby promoting degradation of the target mRNA or blocking its translation into protein (19,(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79).…”

Section: N2bmentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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MicroRNA-155 and antiviral immune responses

Cited by 36 publications

References 176 publications

MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p

MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p

The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

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