MicroRNA‐146b correlates with decreased acute respiratory distress syndrome risk, reduced disease severity, and lower 28‐day mortality in sepsis patients

Chen, Wenfeng; Liu, Huan; Yang, Junhui; Wang, Yujun

doi:10.1002/jcla.23510

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…This review included 26 studies involving a total of 36,995 participants; the results are detailed in Table 1 . The majority (25 studies) [ 10 , 12 – 30 , 32 – 36 ] were cohort studies, and one was a case‒control study [ 31 ]. All the studies were conducted under hospital circumstances.…”

Section: Resultsmentioning

confidence: 99%

Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis

Zhang,

Xu,

et al. 2024

Crit Care

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Background The relationship between smoking and the risk of acute respiratory distress syndrome (ARDS) has been recognized, but the conclusions have been inconsistent. This systematic review and meta-analysis investigated the association between smoking and ARDS risk in adults. Methods The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched for eligible studies published from January 1, 2000, to December 31, 2023. We enrolled adult patients exhibiting clinical risk factors for ARDS and smoking condition. Outcomes were quantified using odds ratios (ORs) for binary variables and mean differences (MDs) for continuous variables, with a standard 95% confidence interval (CI). Results A total of 26 observational studies involving 36,995 patients were included. The meta-analysis revealed a significant association between smoking and an increased risk of ARDS (OR 1.67; 95% CI 1.33–2.08; P < 0.001). Further analysis revealed that the associations between patient-reported smoking history and ARDS occurrence were generally similar to the results of all the studies (OR 1.78; 95% CI 1.38–2.28; P < 0.001). In contrast, patients identified through the detection of tobacco metabolites (cotinine, a metabolite of nicotine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of tobacco products) showed no significant difference in ARDS risk (OR 1.19; 95% CI 0.69–2.05; P = 0.53). The smoking group was younger than the control group (MD − 7.15; 95% CI − 11.58 to − 2.72; P = 0.002). Subgroup analysis revealed that smoking notably elevated the incidence of ARDS with extrapulmonary etiologies (OR 1.85; 95% CI 1.43–2.38; P < 0.001). Publication bias did not affect the integrity of our conclusions. Sensitivity analysis further reinforced the reliability of our aggregated outcomes. Conclusions There is a strong association between smoking and elevated ARDS risk. This emphasizes the need for thorough assessment of patients' smoking status, urging healthcare providers to vigilantly monitor individuals with a history of smoking, especially those with additional extrapulmonary risk factors for ARDS.

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Section: Resultsmentioning

confidence: 99%

Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis

Zhang,

Xu,

et al. 2024

Crit Care

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“…Four studies [ 18 – 20 , 64 ] were included to assess the overall diagnostic performance of miR-146a ( S4 Fig ). The summary sensitivity was 0.77 (95%CI, 0.73 to 0.81), and the specificity was 0.56 (95%CI, 0.51 to 0.61).…”

Section: Resultsmentioning

confidence: 99%

“…Shen et al [13] conducted a meta-analysis in 2020 to validate the diagnostic accuracy of miRNAs for sepsis, and found that miR-223-3p might be used as a sepsis indicator. In recent years, however, a growing number of research have focused on the diagnostic accuracy of miRNAs for sepsis, particularly miR-155-5p [14][15][16], miR-21 [9,10,17], miR-146a [18][19][20], and miR-125a [21][22][23], but the results have been inconsistent. Thus, we collected all published case-control articles to gather evidence on the diagnostic accuracy of miRNAs for sepsis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic significance of microRNAs in sepsis

et al. 2023

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Background Sepsis is a life-threatening condition that induce tens of million death each year, yet early diagnosis remains a formidable challenge. Many studies have focused on the diagnostic accuracy of microRNAs (miRNAs) for sepsis in recent years, particularly miR-155-5p, miR-21, miR-223-3p, miR-146a, and miR-125a. Thus, we conducted this meta-analysis to explore if miRNAs may be used as a biomarker for sepsis detection. Methods We searched PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, and China National Knowledge Infrastructure through May 12, 2022. This meta-analysis was conducted using Meta-disc 1.4 and STATA 15.1 in a fixed/random-effect model. Results The analysis included a total of 50 relevant studies. The overall performance of total miRNAs detection was: pooled sensitivity, 0.76 (95% confidence interval [CI], 0.75 to 0.77); pooled specificity, 0.77 (95%CI, 0.75 to 0.78); and area under the summary receiver operating characteristic curves value (SROC), 0.86. The subgroup analysis suggested that detection in miR-155-5p group had the highest area under the curve (AUC) of SROC among all miRNAs: pooled sensitivity, 0.71 (95%CI, 0.67 to 0.75); pooled specificity, 0.82 (95%CI, 0.76 to 0.86); and SROC, 0.85. MiR-21, miR-223-3p, miR-146a, and miR-125a had SROC values of 0.67, 0.78, 0.69, and 0.74, respectively. The specimen type was found to be a source of heterogeneity in the meta-regression study. The SROC of serum was higher than that of plasma (0.87 and 0.83, respectively). Conclusions Our meta-analysis revealed that miRNAs, specifically miR-155-5p, could be useful biomarkers for detecting sepsis. A clinical serum specimen is also indicated for diagnostic purposes.

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