MicroRNA‐145 contributes to enhancing radiosensitivity of cervical cancer cells

Wang, Hongzhi; Sun, Ning; Ma, Yan; Zhao, Qian; Zhang, Qing; Xu, Chen; Wang, Shaobing; Sun, Shao-Guang; Wang, Fang; Li, Wen

doi:10.1016/j.febslet.2015.01.037

Cited by 50 publications

(36 citation statements)

References 33 publications

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“…Таким обра-зом, было выбрано 18 молекул микроРНК, так назы-ваемых «потенциально маркерных» микроРНК: miR-106 [21,24], miR-1246 [25,26], miR-125b [27][28][29], miR-126 [30][31][32], miR-145 [33,34], miR-146a [35,36], miR-146b [37], miR-155 [38,39], miR-192 [40], miR196b [41], miR-200b [42,43], miR-203 [44,45], miR-20a [46], miR-21 [47,48], miR-31 [49]; miR-34a [27,50]; miR-375 [51,52], miR-99a [53]. Их участие в церви-кальном канцерогенезе было подтверждено как мини-мум в 2 независимых исследованиях.…”

Section: материалы и методыunclassified

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

Архангельская¹,

Samsonov²,

Shtam³

et al. 2017

Tumors of female reproductive system

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Section: материалы и методыunclassified

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

Архангельская¹,

Samsonov²,

Shtam³

et al. 2017

Tumors of female reproductive system

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“…Ye et al [107] reported decreased miR-145 expression in tumors and cervical cell lines when compared with cervical non-tumor tissue and normal cell lines. Five potential targets of miR-145 including HLTF, CUT2, BCR, BUFIP2 and ZCH11A were identified by in silico analysis, but only HLTFs were further investigated due to its mRNA highest expression (1.96-fold).…”

Section: Mirnas Modulate Treatment Response In Cervical Cancermentioning

confidence: 99%

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Bălăcescu¹,

Bălăcescu²,

Baldasici³

et al. 2017

Colposcopy and Cervical Pathology

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Cervical cancer represents one of the major problems of health women worldwide, especially in the developing countries. If discovered in its earliest stages, cervical cancer is successfully treatable; however, due to lack of proper implementation of screening programs, the majority of cervical cancer patients are diagnosed in advanced stages, which dramatically influence their outcome. Almost a half of these patients will suffer recurrence or metastasis in the following 2 years after therapy. If there are no immediate prospects in terms of developing new or more effective therapies, identifying new tools for early diagnosis, prognosis and treatment prediction remains a big challenge for cervical cancer. miRNAs have been validated to be key players in cell physiology, alterations in miRNA expression being associated with cancer progression and response to therapy. Cervical cancer studies have showed that alterations of miRNA expression can be identified in tumor tissues, exfoliated cervical cells and patients serum and that their transcription pattern is regulated by the present HPV genotype. Furthermore, miRNAs have been associated with patients response to therapy, therefore suggesting their potential to be used as biomarkers for cervical cancer diagnosis, prognosis and treatment response.

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“…18 Cellular levels of the proteins specic for the siRNA transfection were checked by immunoblotting.…”

Section: Small Interfering Rna Transfectionmentioning

confidence: 99%

Chloroquine exacerbates serum withdrawal-induced G₁ phase arrest via an autophagy-independent mechanism

et al. 2017

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Chloroquine (CQ) is a widely used anti-malaria or complementary drug in the clinic. However, its effect on ischemic endothelial cells remains unclear. Herein, we showed that serum withdrawal induced G 1 phase arrest and autophagy in human umbilical vein endothelial cells. Moreover, CQ exacerbated serum withdrawal-induced G 1 phase arrest, whereas autophagy inhibition by Atg5 knockdown did not. Pathway analyses of Akt and MEK1/2/ERK1/2 verified the cell cycle difference between CQ and Atg5 knockdown.Additionally, CQ also exacerbated serum withdrawal-induced G 1 phase arrest in the cells with Atg5 knockdown. Through employing glutathione, a reactive oxygen species scavenger, we confirmed that CQ-enhanced intracellular oxidative stress during serum withdrawal aggravated G 1 phase arrest. We thus demonstrate that CQ exacerbates serum withdrawal-induced G 1 phase arrest via an autophagyindependent, but an oxidative stress-dependent mechanism in endothelial cells.

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MicroRNA‐145 contributes to enhancing radiosensitivity of cervical cancer cells

Cited by 50 publications

References 33 publications

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Chloroquine exacerbates serum withdrawal-induced G₁ phase arrest via an autophagy-independent mechanism

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MicroRNA‐145 contributes to enhancing radiosensitivity of cervical cancer cells

Cited by 50 publications

References 33 publications

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

Evaluation of Expression of 4 Mirnas in Cytological Samples as an Additional Method of Cervical Cancer Diagnosis

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Chloroquine exacerbates serum withdrawal-induced G1 phase arrest via an autophagy-independent mechanism

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Product

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Chloroquine exacerbates serum withdrawal-induced G₁ phase arrest via an autophagy-independent mechanism