MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma

Expression Profile of MicroRNAs in Epstein-Barr Virus-Infected AGS Gastric Carcinoma Cells

“…These findings confirm previous findings indicating decreased expression of the miR-200 family of miRNAs in EBV-infected AGS cells and the observation that the levels of miR-200 family members are lower in EBV-positive GCs than in EBV-negative GCs (13,14). Both methods of profiling indicated that miR-143, which has also been shown to act as a tumor suppressor in a number of different types of cancer, was significantly decreased (15)(16)(17).…”

microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2

“…miRNAs, including miR-21, miR-31, miR-577, etc, act as oncogenes, [19][20][21] while others such as Let-7, miR-98, miR-100, miR-138, miR-143, miR-150, etc, function as tumor suppressors. [22][23][24][25][26][27] However, the role of miR-186 in ESCC progression remains uninvestigated.…”

Functions of microRNA-143 in the apoptosis, invasion and migration of nasopharyngeal carcinoma

“…In addition, it has been indicated to be involved in sustaining cell proliferation, resisting cell apoptosis and promoting metastasis in a variety of malignancies (29,30). The overexpression of miR-143 has been demonstrated to inhibit cell growth through the reduction of ERK5 expression in colon cancer, esophageal cancer cells and adipocytes (24)(25)(26)(27)(28)(29)(30)(31)(32). Caspase 3 is a member of the cysteine-aspartic acid protease (caspase) family.…”