MicroRNA-135a regulates sodium–calcium exchanger gene expression and cardiac electrical activity

Duong, Eric; Xiao, Jiening; Qi, Xiao Yan; Nattel, Stanley

doi:10.1016/j.hrthm.2017.01.045

Cited by 13 publications

(13 citation statements)

References 32 publications

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“…Alternatively, miR-135a can modulate the expression of the thioredoxin-interacting protein (TXNIP), protein tyrosine phosphatase 1B (PTP1B) protein, and the transient receptor potential melastatin 7 (TRPM7) channel [ 8 , 18 ]. miR-135a also targets the sodium-calcium exchanger type 1 (NCX1) [ 19 ]. NCX1 activity can be arrhythmogenic causing early- and delayed-after depolarizations [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…miR-135a also targets the sodium-calcium exchanger type 1 (NCX1) [ 19 ]. NCX1 activity can be arrhythmogenic causing early- and delayed-after depolarizations [ 19 ]. The expression and function of NCX can change following a myocardial infarction [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although NCX is one of the prime targets of miR-135a, the neutral effect could be due to a lack of change in the expression levels of NCX in MI groups 8 weeks after surgery compared to the sham group in our study. Increased expression of miR-135a can reduce the spontaneous beating frequency of rat neonatal cardiomyocytes [ 19 ]. Previous work from our lab has shown dietary flaxseed and flaxseed oil is anti-arrhythmic in models of ischemia-reperfusion injury to the heart [ 42 ] and coronary artery ligation-induced MI.…”

Section: Discussionmentioning

confidence: 99%

“…miR-29b is considered to be a master regulator of cardiac fibrosis [ 15 , 16 , 17 ]. Although miR-135a is less widely studied, strong evidence supports its role in arrhythmias and cardiac fibrosis after an MI [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

et al. 2020

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MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). Dietary flaxseed has demonstrated a protective effect against an MI. The present study was carried out to test the hypothesis that dietary flaxseed supplementation before and after an MI regulates the expression of above-mentioned miRNAs to produce its cardioprotective effect. Animals were randomized after inducing MI by coronary artery ligation into: (a) sham MI with normal chow, (b) MI with normal chow, and (c–e) MI supplemented with either 10% milled flaxseed, or 4.4% flax oil enriched in alpha-linolenic acid (ALA), or 0.44% flax lignan secoisolariciresinol diglucoside. The feeding protocol consisted of 2 weeks before and 8 weeks after the surgery. Dietary flax oil supplementation selectively upregulated the cardiac expression of miR-133a, miR-135a, and miR-29b. The levels of collagen I expression were reduced in the flax oil group. We conclude that miR-133a, miR-135a, and miR-29b are sensitive to dietary flax oil, likely due to its rich ALA content. The cardioprotective effect of flaxseed in an MI could be due to modulation of these miRNAs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

et al. 2020

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“…Duoung et al [ 73 ] reported the downregulation of miR-135a in the left ventricle of mice with a complete atrioventricular block induced by His-bundle ablation. The sodium–calcium exchanger type 1 (NCX1) has been identified as the main target of miR-135a [ 73 ].…”

Section: Introductionmentioning

confidence: 99%

A Brief Review on the Biology and Effects of Cellular and Circulating microRNAs on Cardiac Remodeling after Infarction

Parikh

Pierce

2021

IJMS

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Despite advances in diagnostic, prognostic, and treatment modalities, myocardial infarction (MI) remains a leading cause of morbidity and mortality. Impaired cellular signaling after an MI causes maladaptive changes resulting in cardiac remodeling. MicroRNAs (miRNAs/miR) along with other molecular components have been investigated for their involvement in cellular signaling in the pathogenesis of various cardiac conditions like MI. miRNAs are small non-coding RNAs that negatively regulate gene expression. They bind to complementary mRNAs and regulate the rate of protein synthesis by altering the stability of their targeted mRNAs. A single miRNA can modulate several cellular signaling pathways by targeting hundreds of mRNAs. This review focuses on the biogenesis and beneficial effects of cellular and circulating (exosomal) miRNAs on cardiac remodeling after an MI. Particularly, miR-1, -133, 135, and -29 that play an essential role in cardiac remodeling after an MI are described in detail. The limitations that will need to be addressed in the future for the further development of miRNA-based therapeutics for cardiovascular conditions will also be discussed.

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Cardiac small-conductance calcium-activated potassium channels in health and disease

Zhang

Thai

Lieu

et al. 2021

Pflugers Arch - Eur J Physiol

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Small-conductance Ca2+-activated K+ (SK, KCa2) channels are encoded by KCNN genes, including KCNN1, 2, and 3. The channels play critical roles in the regulation of cardiac excitability and are gated solely by beat-to-beat changes in intracellular Ca2+. The family of SK channels consists of three members with differential sensitivity to apamin. All three isoforms are expressed in human hearts. Studies over the past two decades have provided evidence to substantiate the pivotal roles of SK channels, not only in healthy heart but also with diseases including atrial fibrillation (AF), ventricular arrhythmia, and heart failure (HF). SK channels are prominently expressed in atrial myocytes and pacemaking cells, compared to ventricular cells. However, the channels are significantly upregulated in ventricular myocytes in HF and pulmonary veins in AF models. Interests in cardiac SK channels are further fueled by recent studies suggesting the possible roles of SK channels in human AF. Therefore, SK channel may represent a novel therapeutic target for atrial arrhythmias. Furthermore, SK channel function is significantly altered by human calmodulin (CaM) mutations, linked to life-threatening arrhythmia syndromes. The current review will summarize recent progress in our understanding of cardiac SK channels and the roles of SK channels in the heart in health and disease.

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MicroRNA-135a regulates sodium–calcium exchanger gene expression and cardiac electrical activity

Cited by 13 publications

References 32 publications

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression

A Brief Review on the Biology and Effects of Cellular and Circulating microRNAs on Cardiac Remodeling after Infarction

Cardiac small-conductance calcium-activated potassium channels in health and disease

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