MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN

Chen, Zhihua; Zhang, Mengzhen; Qiao, Ying; Yang, Jun‑Juan; Yin, Qinan

doi:10.1080/21691401.2018.1479711

Cited by 18 publications

(17 citation statements)

References 32 publications

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“…Moreover, Ma et al revealed that miR-1275 could pronouncedly abolish the inhibitory effects on cell proliferation and invasion triggered by circMAN2B2 knockdown in A549 and H1299 lung cancer cells [12]. Besides, the results showed that cell proliferation was enhanced while cell apoptosis was declined by miR-1297 overexpression in human cervical carcinoma [28]. As for colony formation, Wang et al revealed that miR-1297 reduced colony formation capacity of glioma cells [29].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Knockdown of hsa_circ_0058124 inhibits the proliferation of human lung cancer cells by up-regulation of miR-1297

Zhang

Yang

2020

Artificial Cells, Nanomedicine, and Biotechnology

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Hsa_circ_0058124 was reported to possess the capacity of enhancing tumorigenesis and invasiveness. This investigation explored the effects of hsa_circ_0058124 on human lung cancer. qRT-PCR was employed for assessing the expression of hsa_circ_0058124 and miR-1297. Cell transfection was conducted for altering the expression of hsa_circ_0058124 and miR-1297. Dual-luciferase reporter gene assay was employed for exploring the relationship between hsa_circ_0058124 and miR-1297. CCK-8 assay, colony formation, flow cytometry, western blot and transwell assay were respectively conducted for exploring the effects of hsa_circ_0058124 silencing and miR-1297 inhibition. The expression of proteins participated in PTEN/AKT and Wnt/b-catenin pathways were determined for exploring the underlying mechanism. Hsa_circ_0058124 was highly expressed in human lung tumour tissues. Besides, hsa_circ_0058124 silencing suppressed cell viability, colony formation, migration and invasion, while enhanced cell apoptosis, which were respectively verified by the regulation of apoptosis-associated and metastasis-related proteins. Additionally, hsa_circ_0058124 silencing inhibited the expression of proteins involved in PTEN/AKT and Wnt/b-catenin pathways including p/t-AKT and b-catenin. miR-1297 was lowly expressed in patients' tumour tissues and was a target of hsa_circ_0058124. Moreover, the above mentioned effects were prominently abrogated by miR-1297 inhibition. This research verified that hsa_circ_0058124 silencing might achieve its anti-tumour roles via inactivation of PTEN/AKT and Wnt/b-catenin pathways through elevating miR-1297 expression.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Knockdown of hsa_circ_0058124 inhibits the proliferation of human lung cancer cells by up-regulation of miR-1297

Zhang

Yang

2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…14 Interestingly, many studies also found that miR-1297 plays a tumor promoting factor in many cancers such as liver cancer, 30 human breast cancer, 31 non-small cell lung cancer 32 and human cervical cancer. 33,34 Wang et al explained that miR-1297 is a tumor-inhibiting factor in glioma. 35 In this report, we also disclosed that loss of miR-1297 recuperates the SNHG5 knockdown-mediated inhibitory effect on cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: LncRNA SNHG5 regulates the cell viability and apoptosis of glioma cells by the miR-1297/KPNA2 axis

Liu

Wang

et al. 2020

RSC Adv.

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“…Cervical cancer is one of the most common cancers and the second leading cause of cancer-related death in women worldwide [1,2], with 274,000 deaths annually [3], which is also a complex disease involving the abnormal expression of many oncogenes and tumour suppressor genes [4]. The discovery of novel therapeutics requires a comprehensive understanding of the disease biology.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

Zhang

Chen

Yan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the spliceosome. There is considerable interest in the compound as a tool to study SF3b1 function in cancer. However, so far little information is available on the molecular mechanism of SF3b1 eliciting apoptosis in cancer cells. Here, we investigated the molecular mechanism of SF3b1 eliciting apoptosis in human cervical carcinoma cells. We demonstrated that inhibition of SF3b1 by pladienolide B inhibited proliferation of HeLa cells at low nanomolar concentrations in a dose-and time-dependent manner. It also induced G2/M phase arrest and significant rise of apoptotic cells. Moreover, it is indicated that inhibition of SF3b1 by pladienolide B induced Tap73/DNp73 expression and consequently down-regulated Bax/Bcl-2 ratio, cytochrome c release and caspase-3 expression. Thus, our results showed that SF3b1 plays a pivotal role in cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells, suggesting that SF3b1 could be used as a potential candidate for cervical cancer therapy.

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MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN

Abstract: Our data indicate that miR-1297 contribute to the human cervical carcinoma through PTEN. miR-1297 could be a reasonable miRNA for future studies.

Cited by 18 publications

References 32 publications

RETRACTED ARTICLE: Knockdown of hsa_circ_0058124 inhibits the proliferation of human lung cancer cells by up-regulation of miR-1297

RETRACTED ARTICLE: Knockdown of hsa_circ_0058124 inhibits the proliferation of human lung cancer cells by up-regulation of miR-1297

Retracted Article: LncRNA SNHG5 regulates the cell viability and apoptosis of glioma cells by the miR-1297/KPNA2 axis

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells

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