Retracted Article: LncRNA SNHG5 regulates the cell viability and apoptosis of glioma cells by the miR-1297/KPNA2 axis

Li, Xueyuan; Liu, Qiankun; Wang, Kang; Luo, Wenzheng; Liang, Tian; Yuan, Shanpeng; Zhen, Yingwei; Yan, Dongming

doi:10.1039/c9ra08693e

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…8A . Some of these lncRNAs have been previously reported as directly involved in heart processes [ 2 , 36 – 44 ]. Figure 8C presents the module’s enrichment analysis according to GO Biological Processes, providing valuable information about the functional categories associated with the genes within the specific module.…”

Section: Resultsmentioning

confidence: 99%

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Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Ramos,

Urquiza-Zurich,

Kim

et al. 2023

Cell Death Dis

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Long non-coding RNAs (lncRNAs) comprise the most representative transcriptional units of the mammalian genome. They are associated with organ development linked with the emergence of cardiovascular diseases. We used bioinformatic approaches, machine learning algorithms, systems biology analyses, and statistical techniques to define co-expression modules linked to heart development and cardiovascular diseases. We also uncovered differentially expressed transcripts in subpopulations of cardiomyocytes. Finally, from this work, we were able to identify eight cardiac cell-types; several new coding, lncRNA, and pcRNA markers; two cardiomyocyte subpopulations at four different time points (ventricle E9.5, left ventricle E11.5, right ventricle E14.5 and left atrium P0) that harbored co-expressed gene modules enriched in mitochondrial, heart development and cardiovascular diseases. Our results evidence the role of particular lncRNAs in heart development and highlight the usage of co-expression modular approaches in the cell-type functional definition.

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Section: Resultsmentioning

confidence: 99%

“…Mural cells are integral components of brain blood vessels that play important roles in vascular formation, regulation of regional cerebral blood flow, regulation of vascular stability, and homeostasis [ 64 ]. Snhg5 has also been reported to participate in the occurrence and development of glioma [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Ramos,

Urquiza-Zurich,

Kim

et al. 2023

Cell Death Dis

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“…Mural cells are integral components of brain blood vessels that play important roles in vascular formation, regulation of regional cerebral blood flow, regulation of vascular stability, and homeostasis [56]. Snhg5 has also been reported to participate in the occurrence and development of glioma [35].…”

Section: Discussionmentioning

confidence: 99%

“…[18], Farbehi et al [19], and Franzén et al [20], then eliminated markers that were classified for more than one cell type. The number of final gene markers for each cell type was: cardiomyocytes (70); endothelial cells (100); fibroblasts and myofibroblasts (140); macrophages and monocytes (128); B-cells (76); dendritic cells (42); glial cells (2); natural killer cells (35); T-cells (59); mural cells, vascular smooth muscle cells and pericytes (42) and myoblasts (16).…”

Section: Methodsmentioning

confidence: 99%

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Single cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Ramos

Kim

Gillette

et al. 2022

Preprint

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Long non-coding RNAs (lncRNAs) comprise the most representative transcriptional units of the mammalian genome, and they’re associated with organ development that can be associated with the emergence of diseases, such as cardiovascular diseases. Thus, we used bioinformatic approaches, machine learning algorithms and statistical techniques to define lncRNAs involved in mammalian cardiac development. We used a single-cell transcriptome dataset generated from 4 embryonic and 4 postnatal stages. Our study identified 8 distinct cell types, novel marker transcripts (coding/lncRNAs) and also, differential expression and functional enrichment analysis reveal cardiomyocyte subpopulations associated with cardiac function; meanwhile modular co-expression analysis reveals cell-specific functional insights for lncRNAs during myocardial development, including a potential association with key genes related to disease and the “fetal gene program”. Our results evidence the role of particular lncRNAs in heart development, and highlights the usage of co-expression modular approaches in the cell-type functional definition.

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Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia

Izadirad

Jafari

James

et al. 2021

Drug Discovery Today

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Retracted Article: LncRNA SNHG5 regulates the cell viability and apoptosis of glioma cells by the miR-1297/KPNA2 axis

Abstract: Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5) has been reported to participate in the occurrence and development of glioma.

Cited by 4 publications

References 37 publications

Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Single-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Single cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development

Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia

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