MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression

Deng, Haoyuan; Song, Zhenyuan; Xu, Huan; Deng, Xinrui; Zhang, Qiao; Chen, Hongyu; Wang, Yanjiao; Qin, Ying; Liu, Ying

doi:10.1159/000475576

Cited by 20 publications

(13 citation statements)

References 53 publications

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“…In a population study, positive correlations between circulating miR-1185 and the endothelial expression of E-selectin and VCAM-1 have been observed, and the expression of these cell adhesion molecules further correlates positively with arterial stiffness, a characteristic of atherosclerosis. In vitro assays confirmed the relation among miR-1185 and E-selectin and VCAM-1, suggesting a miR-1185-E-selectin and VCAM-1-atherosclerosis axis, despite that the direct targets of miR-1185 in the scenario remain elusive (75). Another study that measured the level of miR-122 in blood samples taken from patients and rats suffering from ischemic stroke showed a correlation between a decrease in this miRNA and an increase in expression of direct target genes such as VCAM-1 and indirect target genes such as ICAM-1 in the brain.…”

Section: Mirnas As Paracrine Regulators Of Inflammationmentioning

confidence: 80%

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

2018

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The surface of endothelial cells is covered with cell adhesion molecules, including E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM- 1) , that mediate the adhesion and extravasation of leukocytes and play pivotal roles in inflammatory response. microRNAs (miRNAs) regulate the expression of these important cell adhesion molecules through two distinct major mechanisms, namely via modulating the proinflammatory NF-κB pathway, which controls their transcription, and via directly targeting them. The present review highlights the role of various miRNAs in controlling the expression of E-selectin, ICAM-1, and VCAM-1: a type of regulation that can be harnessed for therapeutic prevention of inflammation-associated diseases such as atherosclerosis and sepsis. The roles of secreted miRNAs as paracrine regulators, and cell adhesion molecule-based miRNA delivery are also addressed.-Zhong, L., Simard, M. J., Huot, J. Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation.

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Section: Mirnas As Paracrine Regulators Of Inflammationmentioning

confidence: 80%

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

2018

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“…VCAM-1 is overexpressed in atherotic plaque after acute hypoxia and its silencing with interfering RNA in vivo decreases granulocyte recruitment to the damaged tissue [44]. Interestingly, the association between a plasma-specific microRNA—miR-1185—and arterial stiffness was found to be partially mediated by VCAM-1 [45]. …”

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

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PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.MethodsSerum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.Results108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4–22.2] vs. 21.6 kg/m2 [19.9–23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1–7.1] vs. 0.5 mg/dL [0.3–1.0], p < 10−10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851–1279] vs. 861 ng/mL [806–979], p < 10−4), sP-selectin levels did not differ (155 ng/mL [129–188] vs. 156 ng/mL [144–177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.ConclusionsWe found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.

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“…For instance, TGF-β induced ICAM-1, and Eselectin expression is regulated by miR-17 [62]. MiR-126 and miR-1185 regulate endothelial expression of VCAM1 [63,108]. ALCAM is reported as a target gene of miR-483-5p [64].…”

Section: Extravasationmentioning

confidence: 99%

microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

et al. 2020

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Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these patients. BM is a complex process that is regulated by the formation of a metastatic niche. A better understanding of the brain metastatic processes and the crosstalk between cancer cells and brain microenvironment is essential for designing a novel therapeutic approach. In this context, the aberrant expression of miRNA has been shown to be associated with BM. These non-coding RNAs/miRNAs regulate metastasis through modulating the formation of a metastatic niche and metabolic reprogramming via regulation of their target genes. However, the role of miRNA in breast cancer brain metastasis (BCBM) is poorly explored. Thus, identification and understanding of miRNAs in the pathobiology of BCBM may identify a novel candidate miRNA for the early diagnosis and prevention of this devastating process. In this review, we focus on understanding the role of candidate miRNAs in the regulation of BC brain metastatic processes as well as designing novel miRNA-based therapeutic strategies for BCBM.Keywords: Breast cancer brain metastasis, miRNA, Brain tumor microenvironment, Blood-brain barrier, CNS metastasis

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MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression

Cited by 20 publications

References 53 publications

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

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