MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis

Wang, Xin; Ling, Chen; Li, Liping; Qin, Yinyin; Qi, Jialing; Liu, Xiaoyu; You, Bo; Shi, Yunwei; Zhang, Jie; Qiu, Jian; Xu, Hui; Sun, Cheng; You, Yiwen; Chai, Renjie; Liu, Dong

doi:10.1093/cvr/cvw023

Cited by 61 publications

(65 citation statements)

References 39 publications

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“…In previous studies, it was proposed that miR-10a/10b targeted cell apoptosis or cell division related genes, such as MIB1 LPO, to induce apoptosis and cell cycle arrest (22,23). Therefore, the current study aimed to explore the relationship between miR-10a-5p and BDNF in the development of cancer.…”

Section: Discussionmentioning

confidence: 98%

MicroRNA‑10a‑5p suppresses cancer proliferation and division in human cervical cancer by targeting BDNF

Zhai¹,

Li²,

Lan³

et al. 2017

Exp Ther Med

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Abstract. The aim of the present study was to investigate the effect and mechanism of microRNA (miR)-10a-5p in human cervical cancer. The expression level of miR-10-5p in cervical cancer lines was assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In cervical cancer HeLa and SiHa cells, miR-10-5p was ectopically overexpressed by lentiviral transduction. Brain-derived neurotrophic factor (BDNF) was then overexpressed in HeLa and SiHa cells to evaluate its selective effect on miR-10-5p in cervical cancer modulation. The targeting of miR-

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Section: Discussionmentioning

confidence: 98%

MicroRNA‑10a‑5p suppresses cancer proliferation and division in human cervical cancer by targeting BDNF

Zhai¹,

Li²,

Lan³

et al. 2017

Exp Ther Med

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“…AB and transgenic zebrafish lines: Tg(fli1a:nEGFP) , Tg(kdrl:EGFP) , Tg(kdrl:ras-mCherry) and Tg(huC:EGFP) were used as described in our previous work [39-42]. Embryos were obtained and treated like we previously did [42]. …”

Section: Methodsmentioning

confidence: 99%

“…Monoclonal Anti-Tubulin (Acetylated antibody produced in mouse) was bought from Sigma (T6793). Immunofluorescence staining and western blot was performed as described previously [40, 42]. …”

Section: Methodsmentioning

confidence: 99%

The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis

et al. 2016

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MAM and EGF containing gene (MAEG), also called Epidermal Growth Factor-like domain multiple 6 (EGFL6), belongs to the epidermal growth factor repeat superfamily. The role of Maeg in zebrafish angiogenesis remains unclear. It was demonstrated that maeg was dynamically expressed in zebrafish developing somite during a time window encompassing many key steps in embryonic angiogenesis. Maeg loss-of-function embryos showed reduced endothelial cell number and filopodia extensions of intersegmental vessels (ISVs). Maeg gain-of-function induced ectopic sprouting evolving into a hyperbranched and functional perfused vasculature. Mechanistically we demonstrate that Maeg promotes angiogenesis dependent on RGD domain and stimulates activation of Akt and Erk signaling in vivo. Loss of Maeg or Itgb1, augmented expression of Notch receptors, and inhibiting Notch signaling or Dll4 partially rescued angiogenic phenotypes suggesting that Notch acts downstream of Itgb1. We conclude that Maeg acts as a positive regulator of angiogenic cell behavior and formation of functional vessels.

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“…MiRNA-10b is a key regulator of genes that control cellular processes, including proliferation and apoptosis [26]. MiRNA 10b also suppresses angiogenesis by up-regulating mib1 and FLT, thereby altering VEGF signaling and resulting in vascular branching defects [27,28]. Furthermore, tissue and circulating levels of miRNA 10b are associated with diffuse myocardial and ventricular structural abnormalities in the setting of ischemic cardiomyopathy [29].…”

Section: Mirnas 125a-5p and 10b Are Dynamic And Associated With Af Rementioning

confidence: 99%

Plasma MicroRNAs Relate to Atrial Fibrillation Recurrence after Catheter Ablation: Longitudinal Findings from the MiRhythm Study

Vaze¹,

Donahue²,

Spring³

et al. 2017

J Clin Exp Cardiolog

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Introduction: Genetic and transcriptomic factors play important roles as mediators of new-onset and recurrent atrial fibrillation (AF). MicroRNAs (miRNAs) regulate expression of gene networks involved in key aspects of atrial remodeling. Associations between circulating miRNAs and AF recurrence are unknown. We tested the hypothesis that cardiac miRNAs associated with electrical and structural remodeling predict recurrent AF rhythm in post-ablation patients.

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MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis

Abstract: Taken together, these results indicate that miR-10 regulates the angiogenic behaviour in a Notch-dependent manner by directly targeting mib1.

Cited by 61 publications

References 39 publications

MicroRNA‑10a‑5p suppresses cancer proliferation and division in human cervical cancer by targeting BDNF

MicroRNA‑10a‑5p suppresses cancer proliferation and division in human cervical cancer by targeting BDNF

The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis

Plasma MicroRNAs Relate to Atrial Fibrillation Recurrence after Catheter Ablation: Longitudinal Findings from the MiRhythm Study

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