MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2

Abstract

miR-101 inhibits cell proliferation and invasion and enhances paclitaxel-induced apoptosis in NSCLC cells, at least in part, by directly repressing EZH2 expression. Therapeutic strategies to rescue miR-101 expression or silence EZH2 may be beneficial to patients with NSCLC in the future.

Roles of MiR-101 and its Target Gene Cox-2 in Early Diagnosis of Cervical Cancer in Uygur Women

“…Of all the different expression microRNA, the significant downregulation of miR-101 in cervical cancers of Uygur women is consistent with the reported decrease of miR-101 in prostate cancer (Pang et al, 2010;), colon (Chandramouli et al, 2012Strillacci et al, 2013), liver cancer (Zhang et al, 2012), non small cell lung cancer (Zhang et al, 2011), breast cancer (Wang et al, 2012), and gastric cancer (Wang et al, 2010). Our data showed that miR-101 expression was significantly reduced in cervical cancer, which may play a critical role in the occurrence and development of cervical cancer.…”

miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives

“…A study investigating the expression of EZH2, a gene overexpressed in NSCLC, showed that miR-101 was capable of inhibiting the growth of tumour cells by inducing the apoptotic pathway associated with the therapeutic effects of paclitaxel [123]. To determine the effects of miR-101 in lung cancer cells, the cells were transfected with miRNA mimics.…”

Non‐coding RNAs and EZH2 interactions in cancer: Long and short tales from the transcriptome

“…42 EZH2 expression levels were increased and negatively associated with miR-101 and miR-128 a expression in bladder transitional cell carcinoma, gastric cancer, glioblastomas, non-small cell lung cancer samples and cell lines, intraductal papillary mucinous neoplasm of the pancreas and adult Tcell leukemia/lymphoma cells (ATL). [43][44][45][46][47] EZH2 overexpression is also associated with a more aggressive type of nasopharyngeal carcinoma (NPC), and is inversely associated with the expression of three downregulated miRNAs; miR-26a, miR-98 and miR-101. In fact, exogenous expression of the three miRNAs resulted in decreased EZH2 transcript levels acting as negative regulators of EZH2.…”